Clinical trials: Diabetes (DM)
Diabete Mellitus, Diabete Type 2
A Pilot Study of the Effectiveness of Foot-Ankle and Walking Exercises in Patients With Diabetes Mellitus
This pilot feasibility and exploratory study, conducted to prepare for a definitive Randomized Controlled Trial (RCT), compares a structured foot-ankle exercise program with a walking exercise program in adults with Diabetes…
- Conditions
- Diabete Mellitus, Diabete Type 2, Diabetic Peripheral Neuropathy, Diabetic Foot
- Trial name
- NCT07270328
- Testing
- Foot-ankle exercise group, Walking exercise group, Control group
- Where
- 3 sites in Indonesia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Diabetes Mellitus, Type 2
Phase 3 Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus
To compare the efficacy of ORMD-0801 to placebo in improving glycemic control as assessed by A1C in inadequately controlled T2DM subjects on diet control alone or on diet control and metformin monotherapy or two or three oral…
- Trial name
- NCT04817215
- Testing
- ORMD-0801
- Volunteers
- 608 people, healthy volunteers welcome
- Sponsor
- King Hamad University Hospital, Bahrain
Diabetes, Hyperglycemia Steroid-induced
Effect of Short Course of Glucocorticoid in Patients With Diabetes Mellitus(DM) Type 2
Participants will receive prednisone 40 mg for 3 days. 75 g oral glucose tolerance test (OGTT), insulin and C-peptide will be measured on day 1 (before prednisone) and day 3 (after prednisone).
- Trial name
- NCT03661684
- Testing
- Prednisone
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cook County Health
Metabolically Unhealty Obese, Dyslipidemia
Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals
This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity.
- Conditions
- Metabolically Unhealty Obese, Dyslipidemia, Diabetes (DM), Resistance, Insulin
- Trial name
- NCT07423884
- Testing
- Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Andalas University
Diabetes (DM), Periodontitis
Relationship Between Diabetes and Periodontitis
Diabetes mellitus, one of the major global health problems of the 21st century, is a chronic metabolic disease characterized by dysregulated nutrient metabolism resulting from defects in insulin secretion and action.
- Trial name
- NCT07193979
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 DM
It is unclear what effect selective serotonin reuptake inhibitors (SSRIs) have on hypoglycemia. Thus, the American Hospital Formulary Service recommends careful monitoring of blood glucose levels in all patients with diabetes…
- Trial name
- NCT00592670
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes (DM), Periodontitis
Nuclear Abnormalities in Gingival Epithelial Cells in Relation to Periodontal Disease
Diabetes mellitus and periodontitis are two highly prevalent chronic diseases with a well-established bidirectional relationship.
- Conditions
- Diabetes (DM), Periodontitis, Periodontitis (Stage 3), Micronuclei Count
- Trial name
- NCT07375719
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Stroke, Shoulder Impingement Syndrome
An Innovative Proprioceptive Instrument for Upper Extremities
This study aimed to develop and validate an innovative proprioceptive assessment instrument for the upper extremities, the PropArm-PosiMoF (PropArm). This observational study was conducted in three stages.
- Conditions
- Stroke, Shoulder Impingement Syndrome, Diabetes (DM), Healthy Young Adults
- Trial name
- NCT07779928
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Type 1 Diabetes, Hypoglycemia Associated Autonomic Failure
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)
Exercise is a cornerstone of diabetes management. It helps reduce blood pressure, promote weight loss, lower insulin resistance and improve glucose and lipid (triglyceride and HDL-cholesterol) profiles.
- Trial name
- NCT01672255
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus
Finding Diabetes Mellitus Among Veterans
Population-based screening for diabetes mellitus in non-pregnant adults remains controversial. For a screening strategy to be successful, patients identified by surveillance will have to have better outcomes than if they had been…
- Trial name
- NCT00007696
- Where
- United States
- Volunteers
- 1,276 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Diabetes Mellitus, Type 2, Diastolic Dysfunction
PDD in Type 2 Diabetes w/wo Diastolic Dysfunction
This study will advance the investigator's knowledge of the integrated cardiorenal and humoral physiology in type 2 diabetic patients with and without pre-clinical diastolic dysfunction, and test a novel therapeutic strategy…
- Trial name
- NCT03744975
- Testing
- LCZ 696
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
DIABETES EDUCATION
The Effect of Kamishibai Diabetes Education on Knowledge, HbA1c, and Quality of Life in Children
Children diagnosed with Type 1 Diabetes Mellitus (T1DM) initially receive intensive education with their families. Studies indicate that over time, this initial education becomes routine, reducing its effectiveness and failing to…
- Trial name
- NCT06535672
- Testing
- kamishibai education, routine education
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Okan University
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Elevations of plasma cortisol, a stress hormone, during prior episodes of low blood sugar (hypoglycemia) appear to be responsible for the deficient responses during subsequent hypoglycemia.
- Trial name
- NCT00607646
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Type 2 Diabetes
Personalizing A1c Using Hematologic Indices and CGM for Accurate Diabetes Diagnosis
The goal of this observational study is to learn why some adults over the age of 65, have A1c tests that do not match up with their blood glucose levels, also known as 'A1c-glucose discordance'.
- Trial name
- PRECISE DM DX (NCT07111416)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Periodontitis, Type 2 Diabetes Mellitus (DM)
Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With Type 2 Diabetes and Periodontitis
Periodontitis is a chronic inflammatory disease that affects the tissues supporting the teeth and can lead to progressive tissue destruction.
- Trial name
- NCT07905209
- Testing
- MTHFR and DNMT3B Genetic Polymorphism Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Colorectal Cancer
Association of Colorectal Cancer With Nutrition, Diet, Obesity, Diabetes Mellitus, and Genetic Alterations in Taiwan
We will explore the genetic (including APC, k-ras, p53, MSI, etc.) and environmental (including family history, life style, diet, nutritional status, DM, serum IGF-I, IGFBP-3, etc.) risk factors of colorectal tumorigenesis.
- Trial name
- NCT00172757
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Controlled Type 2 Diabetic Patients With Periodontitis
Clinical and Radiographic Evaluation of Subgingival 1% Metformin Gel Versus 0.05% Zoledronate Gel as an Adjunct to MINST of Intrabony Defects in Controlled Type 2 DM
The present randomized placebo-controlled trial aims to evaluate and compare the clinical and radiographic efficacy of subgingivally delivered 0.05% zoledronate gel and 1% metformin gel as adjuncts to minimally invasive…
- Trial name
- NCT07753317
- Testing
- All participants will receive MINST
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q2
Alprazolam (Xanax) will blunt the body's ability to defend itself from low blood sugar.
- Trial name
- NCT00592332
- Testing
- Alprazolam, control group
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Effects of HBO on Glucose in Patients With DM
The purpose of this Research Study is: 1. To determine the reliability and performance of the Dexcom G6® continuous glucose monitoring (CGM) system in patients with diabetes undergoing hyperbaric oxygen (HBO2) exposure.
- Trial name
- NCT04261738
- Testing
- Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Legacy Health System
Type 2 Diabetes Mellitus (DM)
Tolerability and Safety of Nano-Tocotrienols
The goal of this randomised controlled trial is to determine the long term safety and tolerability of nano-tocotrienols (50 - 400 mg/day for 6-months duration) to be used as a health supplement in both healthy individuals and…
- Trial name
- NCT07888426
- Testing
- Nano-tocotrienols
- Where
- Malaysia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Malaya