Clinical trials: Diabetes Mellitus II
Diabetes Mellitus, Type 1
Treatment With hOKT3gamma1(Ala-Ala) in T1DM
This is a phase II study to examine the clinical and immunological effects of humanized FcR non-binding anti-CD3 mAb in participants with Type 1 diabetes mellitus (T1DM), and to develop this therapy to prevent the immune…
- Trial name
- NCT00806572
- Testing
- hOKT3gamma1(Ala-Ala)
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes Mellitus
Phase II Pharmacokinetics Study of Humalog and Humulin-R With and Without rHuPH20 in Type 1 Diabetes Mellitus
Humalog and Humulin-R (recombinant human insulin) are Food and Drug Administration (FDA) approved medications for the treatment of diabetes mellitus.
- Trial name
- NCT00774800
- Testing
- Humalog, Humulin-R, Recombinant human hyaluronidase PH20 (rHuPH20)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Halozyme Therapeutics
High Risk Proliferative Diabetic Retinopathy, Diabetes Mellitus Type I
Prospective, Randomized, Open Label, Phase II Study to Assess Efficacy and Safety of Macugen® (Pegaptanib 0.3 mg Intravitreal Injections) Plus Panretinal Photocoagulation and PRP (Monotherapy) in the Treatment With High Risk PDR.
To evaluate the safety and determine the efficacy of PRP monotherapy or combination therapy (pegaptanib 0.3 mg plus PRP) in patients with Type I or Type II diabetes mellitus and with high risk proliferative diabetic retinopathy.
- Conditions
- High Risk Proliferative Diabetic Retinopathy, Diabetes Mellitus Type I, Diabetes Mellitus Type II
- Trial name
- NCT01281098
- Testing
- Panretinal Photocoagulation (PRP), Intravitreous injection of pegaptanib
- Where
- Portugal
- Volunteers
- 22 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Efficacy and Safety of Oral Controlled-release Nicotinic Acid (CIR-NA) for the Remission of Prediabetes. (CONCEPT)
The goal of this clinical trial is to prevent the change from prediabetes (a pre-stage of type 2 diabetes mellitus (T2DM)) to T2DM in participants with prediabetes using oral CIR-NA (a nicotinic acid formulation that is designed…
- Trial name
- CONCEPT (NCT07286747)
- Testing
- controlled-ileal-release nicotinic acid as multiple dose 100 mg/day, controlled-ileal-release nicotinic acid as multiple dose 200 mg/day
- Where
- 6 sites in Germany
- Volunteers
- 390 people
- Sponsor
- University Hospital Schleswig-Holstein
Diabetes Mellitus
Efficacy and Safety of Pioglitazone in Treating Subjects With Vascular Complications Associated With Type 2 Diabetes Mellitus.
The purpose of this study is to determine the efficacy of pioglitazone compared to glibenclamide, once daily (QD), taken together with metformin and lifestyle modification in type 2 diabetic subjects with cardiovascular disease.
- Trial name
- SPLENDOR (NCT00770835)
- Testing
- Pioglitazone and Metformin, Glibenclamide and Metformin
- Where
- 2 sites in Italy
- Volunteers
- 39 people
- Sponsor
- Takeda
Diabetic Nephropathy
Efficacy and Safety Study of Probucol in Patients With Diabetic Nephropathy
This trial is randomized, placebo-controlled, double blind, double dummy, multi-centre trial. Screening period (4 week) Double blind treatment period (16 weeks)
- Trial name
- NCT01726816
- Testing
- Probucol 250mg/day, Probucol 500mg/day
- Where
- 16 sites in South Korea
- Volunteers
- 126 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Diabetes Mellitus
Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to determine the efficacy, safety and tolerability of SYR-472, once daily (QD), in subjects with Type 2 Diabetes Mellitus.
- Trial name
- NCT00653185
- Testing
- SYR-472
- Where
- 87 sites in United States, Chile and 10 more
- Volunteers
- 369 people
- Sponsor
- Takeda
Type 2 Diabetes, Type II Diabetes Mellitus
The GRoceries Aimed at Increasing Nutrition Study
Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes.
- Conditions
- Type 2 Diabetes, Type II Diabetes Mellitus, Type II Diabetes, Pre-diabetes
- Trial name
- GRAINS (NCT07167004)
- Testing
- Marketing Nudges Only, Marketing Nudges + Dynamically Adapted Financial Incentives
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- University of Pennsylvania
Cystic Fibrosis
Comparing Laboratory Blood Glucose Results With HemoCue Glucose 201 RT
There are very few studies comparing the accuracy, sensitivity and specificity of HemoCue glucose 201 RT system with the laboratory gold standard.
- Trial name
- CFRD (NCT01883037)
- Testing
- Blood glucose results
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Type2diabetes, Diabetic Foot
THE EFFECT OF ONLINE TRAINING ON FOOT CARE
The aim of this study is to determine the effect of online trainings on diabetic foot care on foot care behavior and self-efficacy attitudes of individuals with type II diabetes.
- Trial name
- NCT05473494
- Testing
- training group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
The PRECISION II Study: Evaluating the Accuracy of the LabPatch Glucose Sensing System
The purpose of this study is to evaluate the accuracy of the Cambridge Medical Technologies, LLC second generation (2nd Gen) LabPatch glucose sensing system compared to a laboratory glucose analyzer (YSI 2300 STAT Plus) and 2…
- Trial name
- NCT05754281
- Testing
- 2nd Gen LabPatch Glucose Sensing System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joslin Diabetes Center
Diabetic Foot Ulcer
Safety and Efficacy of Stem Cells for Diabetic Foot Ulcer
The objective of this clinical trial is to evaluate the effectiveness and safety of Wharton-Jelly mesenchymal stem cells administered around the ulcer site in patients with nonhealing diabetic foot ulcers.
- Trial name
- NCT06231771
- Testing
- Allogeneic mesenchymal stem cells (MSCs), Normal Saline
- Volunteers
- 22 people
- Sponsor
- Supergenics Life Science Sdn. Bhd.
Diabetic Polyneuropathy
Painful Diabetic Polyneuropathy Trial With a New Centrally Acting Analgesic
The purpose of this trial is to determine whether the new centrally active analgesic and MS Continus® are effective in the treatment of painful diabetic polyneuropathy.
- Trial name
- NCT00878293
- Testing
- GRT6005, MS Continus®
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 90 people
- Sponsor
- Tris Pharma, Inc.
Type II Diabetes Mellitus
Study to Evaluate the Safety and Pharmacokinetics of CKD-379
A study to compare the pharmacokinetics and safety between CKD-379 and D759, D745, D029, D150 combination
- Trial name
- NCT05952219
- Testing
- CKD-379, D759+D745+D029+D150
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Diabetes Mellitus Type 2
HbA1c Variability in Type II Diabetes
There are numerous possible reasons why it could be speculated that HbA1c variability may affect complication risk. Of interest are the concepts that both laboratory and clinic evidence suggests that periods of sustained…
- Trial name
- NCT02879409
- Testing
- Metformin, Gliclazide, Sitagliptin
- Where
- Qatar
- Volunteers
- 150 people
- Sponsor
- Weill Cornell Medical College in Qatar
Diabetes Mellitus, Type II [Non-insulin Dependent Type] [NIDDM Type] Uncontrolled
Nutrition Education Intervention in Adults With Type 2 Diabetes Mellitus in a Resource Poor Setting
The purpose of this study is to implement a nutrition education programme that was developed for type 2 diabetic adults in a resource poor setting and to evaluate the programme's effectiveness on health outcomes A randomized…
- Trial name
- NCT01095965
- Testing
- Nutrition education
- Where
- South Africa
- Volunteers
- 82 people
- Sponsor
- University of Pretoria
Type II Diabetes
Evaluation of a Prototype Diabetes Management System Applied to Insulin Initiation and Titration
The purpose of this study is to determine if using a diabetes management technology system, including a tablet computer, to track diabetes care and communicate with a clinician coach (a doctor or nurse from the Joslin Clinic)…
- Trial name
- NCT01698528
- Testing
- Tablet Computer
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Joslin Diabetes Center
Diabetes Mellitus
Efficacy and Safety of Pioglitazone and Azilsartan in Treating Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to determine the efficacy of pioglitazone, once daily (QD), combined with azilsartan in the treatment of subjects with Type 2 Diabetes Mellitus.
- Trial name
- NCT00762736
- Testing
- Pioglitazone and azilsartan, Pioglitazone
- Where
- 78 sites in United States, Argentina and 3 more
- Volunteers
- 704 people
- Sponsor
- Takeda
Type II Diabetes
Activator and Type II Diabetics
The purpose of this study (15-subject prospective case series) is to examine the effects of the Activator Methods technique on decreasing A1c levels in patients with type II Diabetes Mellitus (aka adult-onset diabetes).
- Trial name
- NCT01782092
- Testing
- Chiropractic Adjustment
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Life University
Type2 Diabetes, Depression
Program ACTIVE II: Behavioral Depression Treatment for Type 2 Diabetes
Program ACTIVE II is a depression treatment study sponsored by the National Institutes of Health, Indiana University, Ohio University and West Virginia University.
- Trial name
- NCT03371940
- Testing
- Program ACTIVE Exercise, Program ACTIVE CBT, Program ACTIVE
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Indiana University