Clinical trials: Diabetes Risk
Type 1 Diabetes
Primary Intervention With Mucosal Insulin
A dose with proven drug bioavailability to the immune system for use in a phase II/III primary T1DM (type 1 diabetes) vaccination trial (POINT study) in genetically at risk subjects.
- Trial name
- Pre-POINT (NCT02620553)
- Testing
- Human Insulin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type2 Diabetes, Sleep
Experimental Changes in Children's Sleep Duration and Timing: Effect on Obesity and Type 2 Diabetes Risk
Enhancing children's sleep duration and/or timing may represent a novel approach for weight regulation and prevention of T2DM. The proposed study will assess how experimental changes in children's sleep duration and timing affect…
- Trial name
- NCT02979860
- Testing
- Sleep duration 90 min, Sleep duration 45 min, Sleep timing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Temple University
Type 1 Diabetes Mellitus
Exercise Training Intervention in Children With Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is associated with multiple co-morbidities, such as hypertension, dyslipidemia, coronary heart disease and osteoporosis. The foundation of these conditions lays in childhood.
- Trial name
- Diabex (NCT01220479)
- Testing
- Exercise training program
- Where
- Switzerland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Type 2 Diabetes Mellitus
The Effects of Reducing Prolonged Sitting Bouts in Individuals at High Risk of or With Type 2 Diabetes
Over 3 million in the United Kingdom are now diagnosed with type 2 diabetes, with current estimates suggesting this will rise to over 5 million by 2025.
- Trial name
- UP FOR 5 (NCT03482596)
- Testing
- Reducing/breaking prolonged sitting
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Cardiometabolic Health, Pregnancy Related
Cardiometabolic Health in First Time Pregnancy
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth…
- Conditions
- Cardiometabolic Health, Pregnancy Related, Diabetes, Placental; Syndrome, Dysfunction
- Trial name
- POPPY (NCT05856318)
- Where
- 7 sites in United Kingdom
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)
This is a pragmatic, risk-stratified, individually randomized controlled trial testing whether personalised WhatsApp-based digital behavioural nudges can improve completion of cardiovascular preventive actions after community…
- Trial name
- NADI-MHR (NCT07879144)
- Testing
- Personalised Digital Behavioural Nudges (NADI-MyHeartRisk Enhanced Pathway)
- Where
- 2 sites in Malaysia
- Volunteers
- 6,588 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Advancement and Research Excellence Institute
Obesity, Prediabetic State
Effect of Melatonin on Cardiometabolic Risk- FULL
In a 12 week double-blind, placebo-controlled randomized trial, 120 subjects with obesity (BMI≥30 kg/m2) and pre-diabetes (HbA1c, 5.7-6.4%) will be randomly assigned 1:1 to receive either placebo or 2 mg of controlled-release…
- Trial name
- NCT02681887
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus
Potential Correlation Between Heart Rate Variability With Cardiovascular Risk at Different Stages of Metabolic Syndrome
The study aims to assess the beat-to-beat Heart rate variability (HRV) in different stages of metabolic diseases, including pre-diabetic and diabetic patients, compared to non-diabetic individuals.
- Trial name
- NCT06305195
- Testing
- heart rate variability test
- Where
- Egypt
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Gestational Diabetes
Soy Supplementation and Gestational Diabetes
The purpose of this study is to assess the feasibility of randomizing pregnant women at high risk for gestational diabetes to a 24-week period of soy food consumption.
- Trial name
- NCT02806739
- Testing
- Soy Group (Soy Protein + Isoflavones), Control Group (Minimize Soy Intake)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Overweight, Obesity
Diet Quality and Diabetes Risk in Overweight and Obese Adults
The goal of this observational study is to learn about the relationship between diabetes risk with sociodemographic characteristics, lifestyle and diet quality in overweight and obese individuals.
- Trial name
- NCT06614075
- Testing
- Questionnaire and anthropometric measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 1,840 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Overweight, Cardiovascular Diseases
Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes
Cardiovascular disease (CVD) and diabetes are health conditions that are strongly influenced by a person's diet. Although the best diet to prevent CVD and diabetes is uncertain, reducing intake of saturated and transunsaturated…
- Trial name
- NCT00608049
- Testing
- High carbohydrate and low glycemic index (GI) diet, Low carbohydrate and low GI diet, High carbohydrate and high GI diet
- Where
- 2 sites in United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Coronary Heart Disease, Stroke
Evaluating Tools for Health Promotion and Disease Prevention
The study will evaluate the effect of familial risk assessment and prevention prompts tailored to familial risk on health behaviors and use of preventive services among adults who are members of primary care practices in the U.S.
- Conditions
- Coronary Heart Disease, Stroke, Diabetes, Breast Cancer
- Trial name
- NCT00164658
- Testing
- Familial risk assessment and personalized prevention messages
- Where
- 3 sites in United States
- Volunteers
- 8,400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Gestational Diabetes Mellitus (GDM), Glucose Intolerance During Pregnancy
Early Screening for Gestational Diabetes Mellitus in a Low Risk Population
This new feasibility pilot study aims to refine the design and protocols for a larger trial that will investigate the potential benefits of early oral glucose tolerance test (OGTT) screening in a population traditionally defined…
- Trial name
- EaGeR (NCT06704035)
- Testing
- Early OGTT Results Revealed
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Sleep, Diabetes
Individual Differences in Diabetes Risk: Role of Sleep Disturbances
The hypothesis for this study is that some individuals may be at much higher risk to develop type 2 diabetes and that the individual diabetes risk will be predicted by the individual level of slow wave sleep activity (SWA).
- Trial name
- NCT00989976
- Testing
- normal sleep times, bedtime restriction
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Type 1 Diabetes Mellitus
Establishment of Screening Pathway for High-Risk Population of Type 1 Diabetes
This study aims to establish a system for identifying and screening high-risk individuals for type 1 diabetes (T1D) and a standardized management pathway for high-risk individuals. It is a prospective cohort study.
- Trial name
- NCT07468474
- Testing
- Gene polymorphic detection
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Cardiovascular Health, Self-management
MECA Clinical Intervention ( MECA Health360x)
The purpose of this research is to test whether a technology application(Health360x) that lets participants set goals for better health and track health can help participants reduce their heart disease risk.
- Trial name
- MECAH360x (NCT04791618)
- Testing
- Health360x plus health coach, Health360x only (High tech)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Infant Overweight, Infant Obesity
Project Sueño: Sleep & Understanding Early Nutrition in Obesity
The purpose of the study is to understand how mothers think and feel about feeding their babies and putting them to sleep, understand more about programs that can support mothers taking care of babies, and how professionals can…
- Conditions
- Infant Overweight, Infant Obesity, Infant Overnutrition, Infant Development
- Trial name
- NCT06117631
- Testing
- Centering Parenting, Bright by Text
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Mobile Health Apps, Lifestyle Intervention
Effectiveness of an AI-Enabled Mobile Intervention on Lifestyle Behaviors and Maternal-Infant Health
The goal of this pragmatic randomized controlled trial is to evaluate the effectiveness of an AI-enabled mobile health management application ("Better Pregnancy" app), grounded in the Theory of Planned Behavior, in preventing…
- Conditions
- Mobile Health Apps, Lifestyle Intervention, Prevention, Multi-component Based Behavioral Intervention
- Trial name
- NCT07582068
- Testing
- Multi-component lifestyle intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Diet Modification, Substance Use Disorders
The Impact of a Parenting Intervention on Latino Youth Health Behaviors
The purpose of this study is to test if a parenting program can be used to prevent substance use among Latino youth and at the same time promote healthy eating.
- Conditions
- Diet Modification, Substance Use Disorders, Diabetes Mellitus Risk, Cardiovascular Risk Factor
- Trial name
- FPNG+ (NCT03517111)
- Testing
- Nutrition/substance use prevention, Substance use prevention only, Academic success program
- Where
- United States
- Volunteers
- 844 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Type 2 Diabetes, Gestational Diabetes Mellitus (GDM)
Co-designing Enhanced Models of Care for First Nations Children at Risk for Childhood-onset Type 2 Diabetes
The overall objective: to co-design and implement targeted and timely community led strategies to improve the health of the Next Generation and end the intergenerational impact of T2D in this population.
- Trial name
- NCT07692321
- Testing
- Breastfeeding and perinatal education and support, Purchasing HbA1c machines for communities, Continuous Glucose Monitoring
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba