Clinical trials: Diagnostic Accuracy
Jaw Tracking
Comparing Jaw Tracking and Traditional Methods for Measuring Bite Accuracy in Patients With Teeth
This study compares two methods used to measure how teeth come together (occlusal contacts) in patients who have natural teeth (dentate patients).
- Trial name
- NCT07203703
- Testing
- Jaw Tracking Device
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Omer Abdelmagid
Cow's Milk Allergy
Diagnostic Accuracy and Safety of DBV1605 for the Diagnosis of Non-IgE Mediated Cow's Milk Allergy in Children
Study to assess the diagnostic accuracy (sensitivity, specificity, positive and negative predictive value) of DBV1605 for the diagnosis of non-Immunoglobulin E (IgE) mediated cow's milk allergy (CMA) in children with symptoms…
- Trial name
- APTITUDE (NCT04492683)
- Testing
- DBV1605
- Where
- 33 sites in United States, Canada and 2 more
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- DBV Technologies
Dental Trauma
Laser Doppler Flowmetry in Assessing the Vitality of Traumatised Teeth
Teeth injuries are considered one of the most challenging events that occur in dentistry, especially in children. After an injury, there is a possibility that the blood supply to the tooth may become affected and compromised…
- Trial name
- NCT03005197
- Testing
- Laser Doppler Flowmetry
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Gingival Thickness, Gingival Biotype
The Use Of Specially Designed Probe Versus Cone- Beam Computerized Tomography In The Measurement Of Gingival Thickness: Diagnostic Accuracy Study
Accurate measurement of gingival thickness is crucial for decision making in the field of Periodontology and implant dentistry. Currently implemented techniques for the detection of gingival biotype are of limited reliability.
- Conditions
- Gingival Thickness, Gingival Biotype, Periodontal Probe
- Trial name
- NCT03628742
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Secondary Caries Around Resin Composite Restorations
Validity of Fluorescence-Based Devices Versus Visual-Tactile Method in Detection of Secondary Caries Around Resin Composite Restorations: Invivo Diagnostic Accuracy Study
This study will be conducted to evaluate the clinical performance and validity of both light-induced fluorescence intraoral camera and laser-induced fluorescence device in comparison to visual-tactile assessment method in…
- Trial name
- NCT04426604
- Testing
- Light induced fluorescence intraoral camera, Laser-induced fluorescence device, Visual-tactile assessment method according to FDI criteria
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Detecting Number of Root Canal of Human Mandibular Second Molar
Accuracy of Artificial Intelligence Technology in Detecting Number of Root Canal of Human Mandibular Second Molar: Diagnostic Accuracy Experimental Study
to detect the Accuracy of Artificial Intelligence Technology in Detecting Number of Root Canal of Human Mandibular Second Molar: Diagnostic Accuracy Experimental Study.
- Trial name
- AI (NCT07319221)
- Testing
- AI, CBCT
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Root Canal Treatment
On Previously Root Canal-treated Patients Using an AI Program, Detect the Accuracy of it in the Detection of Root Canal Obturation Quality on CBCT Compared With Conventional PA Radiography, e.g., Voids, Length of Obturation, and Density, and Then do Retreatment if Any Failure is Recorded.
aims to evaluate the accuracy of clinicians (conventional radiograph) compared to cone beam computed tomography (CBCT) and artificial intelligence software's ability to identify the quality of root canal obturation.
- Trial name
- AI (NCT07056998)
- Testing
- root canal retreatment
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Tala Ghassan Hassan Odeh
Interstitial Lung Disease (ILD)
Better Tests- Improving Diagnostic Accuracy and Prognostication in Interstitial Lung Diseases
Patients with interstitial lung diseases (ILD) suffer significant delays in obtaining a diagnosis, and objective evidence of support for immunosuppressive therapies, due to weaknesses in the diagnostic tests available in ILD…
- Trial name
- Better Tests (NCT07615504)
- Where
- 3 sites in United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Dundee
Endometriosis, Diagnosis
Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers
This study is testing a way to diagnose endometriosis using a uterine tissue biopsy (similar to a pap smear) as opposed to undergoing laparoscopy surgery.
- Trial name
- NCT05698212
- Testing
- MetriDx
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hera Biotech, Inc.
Acute Appendicitis
Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis
The goal of this prospective observational study is to evaluate the diagnostic accuracy of pro-adrenomedullin (Pro-ADM) in adults with acute appendicitis and compare its performance with conventional inflammatory biomarkers…
- Trial name
- PROADM-APP (NCT07889544)
- Testing
- Serum Pro-Adrenomedullin Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Multiple Sclerosis
Accurate Diagnosis of Multiple Sclerosis Using PET/MR
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease of the central nervous system. Its main feature is progressive demyelination, which ultimately leads to axon damage and neuron loss.
- Trial name
- NCT04521439
- Testing
- 18F-florbetapir PET+MRSI
- Where
- China
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Differential Diagnosis, Diagnostic Accuracy
Evaluation of One-Shot Vision Differential Diagnosis (OSVDE) and Multi-Step Conversational Non-Inferiority (MSCNE) in AI Medical Interviewing
This study evaluates the diagnostic performance of a multimodal artificial intelligence (AI) system (AIMD.1) using de-identified medical images and semi-synthetic patient simulations.
- Trial name
- OSVDE-MSCNE (NCT07470463)
- Testing
- AI Diagnostic System (AIMD.1)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Magic Health Inc. (d.b.a. Nolla Health)
Dental Caries (Diagnosis), Diagnostic Imaging
Diagnostic Performance and Children's Acceptance of Near-Infrared Light Transillumination and Bitewing Radiographs for Detecting Proximal Cavitation in Primary Molars of Patients Aged 4 to 10 Years
The goal of this observational study is to compare the diagnostic performance of three detection methods for approximal carious lesions in primary molars among pediatric patients aged 4-10 years.
- Conditions
- Dental Caries (Diagnosis), Diagnostic Imaging, Optical Imaging, Radiographic Image Interpretation, Computer-Assisted
- Trial name
- NILT (NCT07041164)
- Testing
- Bitewing radiograph, Near-infrared light transillumination
- Where
- 2 sites in Thailand
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Sawanya Prutthithaworn
Prostate Cancer, Risk Assessment
PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria
This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk…
- Conditions
- Prostate Cancer, Risk Assessment, Clinical Decision Support Systems, Predictive Value of Tests
- Trial name
- PROACT (NCT07733440)
- Testing
- (a) Training and (b) Supported risk assessment
- Where
- Nigeria
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University
G6PD Deficiency
Validation of a Diagnostic Test for Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency in Anti-coagulated Blood
The primary objective of the study is to assess the accuracy of the SD Biosensor STANDARD™ point-of-care (POC) G6PD test in measuring G6PD activity and classifying results compared to a reference assay and across repeated…
- Trial name
- NCT04054661
- Testing
- SD Biosensor STANDARD G6PD Test, Pointe Scientific Test Kit, HemoCue System
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- PATH
Helicobacter Pylori Infection
The Diagnostic Validity of the Urea Breath Test
1. To compare the diagnostic accuracy of the 13C-Urea breath test between using the citric acid as test meal and controlled group by endoscopic biopsy methods(histology, CLOtest and H. pylori culture). 2.
- Trial name
- NCT02359942
- Testing
- Citric acid
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Esophageal Squamous Cell Carcinoma, Benign Lymph Node Neoplasm
Quantitative Analysis of 18F-FAPI Dynamic PET/CT for Accurate Differential Diagnosis of MLN of ESCC
Patients diagnosed with esophageal squamous cell carcinoma based on clinicopathology, laboratory examination and imaging criteria were selected as the research subjects, and compared with conventional 18F-FDG PET/CT.
- Conditions
- Esophageal Squamous Cell Carcinoma, Benign Lymph Node Neoplasm, Malignant Lymph Node Neoplasm
- Trial name
- NCT05287880
- Testing
- Dynamic PET/CT
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Diagnostic Error
Quality of Medical History Taking and Diagnostic Accuracy
This prospective randomized simulator-based single-blind trial aimed to investigate the effects of initial cues and history taking skills on diagnostic accuracy
- Trial name
- NCT05760859
- Testing
- Initial cue
- Where
- Switzerland
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Attention-Deficit, Hyperactivity Disorder
Diagnostic Accuracy and Safety of the Attention-Deficit/Hyperactivity Disorder Auxiliary Evaluation System (AHEF) in Chinese Children Aged 6 to 12
This clinical trial aims to evaluate the diagnostic efficacy and safety of the Attention Deficit Hyperactivity Disorder Assessment System (AHEF) in children aged 6 to 12 in China, while ensuring the safety of the subjects and…
- Trial name
- NCT07683156
- Testing
- AHEF
- Where
- 8 sites in China
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- Chongqing Jinsaixing Medical Technology Co., Ltd
Melanoma, Skin Cancer
AI Augmented Training for Skin Specialists
Background: The worldwide incidence of skin cancer has been rising for 50 years, in particular the incidence of malignant melanoma has increased approx. 2-7% annually and is the most common cancer amongst Danes aged 15-34.
- Trial name
- AISC-SS (NCT04758988)
- Testing
- DermLoop Learn
- Where
- 2 sites in Denmark
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital