Clinical trials: Disc Disease
Lumbar Disc Herniation, Gait Analysis
Effect of Chuna Manipulation Therapy on Gait in Patients With Lumbar Disc Herniation
Prospective Observation Study of the Effect of Chuna Manipulation Therapy on Gait in Patients With Lumbar Disc Herniation
- Conditions
- Lumbar Disc Herniation, Gait Analysis, Manual Therapy
- Trial name
- NCT03858556
- Testing
- Chuna manipulation, Herbal medicine, Bee venom pharmacopuncture
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jaseng Medical Foundation
Posterior Vitreous Detachment, Vitreomacular Traction
Vitreopapillary Interface and Optic Disc Morphology
The vitreous fills the posterior chamber of the eye and is firmly attached, at the posterior pole, to the macula and the optic nerve head (ONH).
- Conditions
- Posterior Vitreous Detachment, Vitreomacular Traction, Glaucoma, Vitreopapillary Traction
- Trial name
- NCT02290795
- Testing
- OCT imaging/HRT imaging
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Discogenic Pain
Bone Marrow Concentrate Intradiscal Injection for Chronic Discogenic Low Back Pain
A double-blind, placebo-controlled study to determine the efficacy of intradiscal injection of bone marrow concentrate on discogenic low back pain.
- Trial name
- NCT03340818
- Testing
- Bone Marrow Concentrate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- APM Spine and Sports Physicians
Retina Disease, Glaucoma
Optic Disc Photograph Collection Study
The objective of this study is to collect stereo-optic disc photographs for potential future analysis.
- Conditions
- Retina Disease, Glaucoma, Normal
- Trial name
- NCT05532410
- Testing
- Fundus Camera
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Healthy
Components of Chlorhexidine Gluconate Dressing
The purpose of this study is to determine the contents of a chlorhexidine-containing dressing after use.
- Trial name
- NCT01112020
- Testing
- CHG Catheter Dressing Patch, Biopatch, Tegaderm CHG
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- C. R. Bard
Chronic Sciatica, Foot Deformity
Foot Orthoses in Patients With Sciatica
Chronic sciatica is a frequent problem whose symptoms could be related to the abnormal stresses applied to the musculoskeletal system during the gait cycle due to foot alterations.
- Trial name
- NCT05129540
- Testing
- Custom-made foot orthosis
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Seville
Intervertebral Disc Degeneration
Adjacent Segment Mechanics in Cervical Arthrodesis Patients
This study aims to determine to what extent patient-specific factors, iatrogenic factors, and biomechanical factors influence cervical spine mechanics after single-level and two-level arthrodesis.
- Trial name
- NCT03028402
- Testing
- C5-C6 arthrodesis
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Optic Disc Edema, Endothelial Dysfunction
B-Complex: A Nutraceutical SANS Countermeasure
In this project, the investigators propose to test effectiveness of a daily nutraceutical supplement containing bioactive B vitamins to mitigate optic disc edema in astronauts.
- Trial name
- NCT05366933
- Testing
- Vitamin B-Complex Supplement
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Lumbar Disc Herniation
Remission of Lumbar Disc Herniation by Physiotherapy
This study was conducted with the aim of determining whether or not Non surgical spinal decompression therapy was effective in remission of herniation, decreasing pain and improving functional status.
- Trial name
- NCT02699164
- Testing
- DRX 9000, Axiom Worldwide, Tampa, Florida, physiotherapy, spinal stabilization exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Lumbar Disc Herniation
Brain Effect Mechanism of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
The clinical symptoms of Lumbar Disc Herniation (LDH) can be effectively ameliorated through Spinal Manipulative Therapy (SMT), which is closely linked to the brain's pain-regulating mechanisms.
- Trial name
- NCT06277739
- Testing
- Spinal Manipulative Therapy
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhou Xingchen
Degenerative Disc Disease, Spinal Stenosis
Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)
The purpose of this patient registry is to prospectively collect data on patients who are having spinal surgery with EBI and Interpore Cross Spine Products.
- Trial name
- SPO (NCT00726284)
- Where
- 5 sites in United States
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Open Angle Glaucoma
Does the Optic Disc Grading Done Visually by Your Doctor Agree With Optic Nerve Testing Which is Done by Machines?
The purpose of this study is to determine how well the DDLS (Disc Damage Likelihood Scale) (which is a method used by the eye doctor to evaluate how healthy the optic nerve is) measures up to the standard glaucoma tests: OCT…
- Trial name
- NCT00430287
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Low Back Pain, Disc Disease
Fibrin for Chronic Multi-level Discogenic Low Back Pain
Intra-annular injections of non-autologous fibrin for moderate to severe chronic low back pain (LBP).
- Conditions
- Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy
- Trial name
- NCT04621799
- Testing
- Fibrin sealant
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Pauza, Kevin, MD
Lumbar Disc Herniation, Multimodal Brain Function
Brain Effect Mechanism of Lever Positioning Manipulation on LDH Analgesia Based on Multimodal MRI
In order to further investigate the key brain targets and central response mechanism characteristics of analgesia, the dominant disease of LDH was taken as the object of this study, which was divided into operation group, comfort…
- Conditions
- Lumbar Disc Herniation, Multimodal Brain Function, Analgesia Mechanism, Lever Positioning Manipulation
- Trial name
- NCT05613179
- Testing
- Group1 (lever positioning manipulation)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Stenosis, Herniated Nucleus Pulposus
Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion
Neural injury is a well-known complication following extreme lateral lumbar interbody fusion (XLIF). It has been found that up to 9.4% of patients will have either temporary or persistent neurologic deficit.
- Conditions
- Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis
- Trial name
- NCT03327272
- Testing
- Methylprednisolone, Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Clinical Decision-Making and Virtual Reality Exercise
Degenerative lumbar spine disease (DLSD) is common in elderly individuals and can result in pain, muscle weakness, and paresthesia.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
- Trial name
- NCT05375201
- Testing
- VR skateboarding training
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
TMJ Disc Disorder
a Comparison of the Outcomes Following Intra-articular Dextrose 5% Injection Versus Arthrocentesis in Patients With Anterior Disc Displacement With Reduction of the Tomporomandibular Joint
The Aim of this study is to evaluate the efficacy of intra-articular Dextrose injection with concentration 5% in superior joint space of TMJ in comparison to arthrocentesis in patients with anterior disc displacement with…
- Trial name
- NCT07129681
- Testing
- dextrose 5%, Arthrocentesis/Saline
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
TMJ Disc Disorder
Assessment of Concentric Needle Technique in Temporomandibular Joint (TMJ) Internal Derangement.
The aim of the study is to evaluate the effectivenes of using two concentric needles in comaprsion with the normal traditional two distant needles.
- Trial name
- NCT05510336
- Testing
- Arthrocentesis
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lumbar Disc Degeneration, Low Back Pain
Interleukin-1β (rs 1143627 T/C) Gene Polymorphism May Increase the Risk of Developing LDD in Turkish Population
This study aims to show the association between the Interleukin-1β (rs 1143627 T/C) gene polymorphism and the patient's pain level, radiological features, functional disability, and spinal flexibility.
- Conditions
- Lumbar Disc Degeneration, Low Back Pain, Inflammation
- Trial name
- NCT05601739
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yeditepe University