Clinical trials: Discitis
Spondylodiscitis
Cytokine Profiles and suPAR in Spondylodiscitis
Spondylodiscitis is an infectious disease of the intervertebral discs and adjacent vertebral bodies, which often has a protracted progression.
- Trial name
- NCT02554227
- Testing
- Cytokine Profile and suPAR
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- University of Cologne
Vertebral Osteomyelitis
Comparison of Two Antimicrobial Therapy Duration for Spondylodiscitis
Duration of antimicrobial therapy for spondylodiscitis is not standardized; it could vary from 6 weeks to several months depending on the medical habits.
- Trial name
- DTS (NCT00764114)
- Testing
- antibiotic
- Where
- France
- Volunteers
- 351 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vertebral Osteomyelitis, Spondylodiscitis
Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis
The optimal treatment of uncomplicated native vertebral osteomyelitis (NVO) is unknown. While some authors recommend surgical treatment (consisting of spinal debridement, decompression and instrumentation using hardware…
- Conditions
- Vertebral Osteomyelitis, Spondylodiscitis, Surgical Procedure, Unspecified
- Trial name
- NCT04436328
- Testing
- Surgical treatment, Antimicrobial treatment
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Spondylodiscitis
Follow up Patients With Thoracolumbar Spondylodiscitis Surgically Treated by Posterior Approach
To evaluate the long term outcomes of patients with thoracolumbar spondylodiscitis treated surgically by posterior approach. Outcomes include bony fusion, neurological improvement, pain improvement, implant related complication…
- Trial name
- NCT04749082
- Volunteers
- 40 people
- Sponsor
- Assiut University
Spondylodiscitis
CORset Versus OstéoSynthese in Adult Pyogenic Spondylodiscitis
Pyogenic spondylitis in adults is usually treated by antibiotics according to bacteria evidenced in a diagnostic intervertebral disc puncture.
- Trial name
- COROSIVE (NCT03524209)
- Testing
- Percutaneous instrumentation of the thoracolumbar spine, Brace
- Where
- 15 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Spondylodiscitis, Spinal Infection
Evaluation of Outcomes of Surgical Treatment for Nonspecific Infectious Spondylodiscitis Via Posterior Approach in One Center.
Non-specific spondylodiscitis is a bacterial infection of the spine that in some cases requires surgical treatment. The basis of surgical treatment is the removal of affected tissues.
- Conditions
- Spondylodiscitis, Spinal Infection, Spondylitis, Discitis
- Trial name
- NCT07349602
- Testing
- Posterior approach to infection site
- Where
- Russia
- Volunteers
- 47 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Management of Spondylodiscitis
Rigid Corset Immobilisation of Patients Suffering From Spondylodiscitis: Practice Assessment
Our study is a survey of the current management of patients suffering from spondylodiscitis.
- Trial name
- Cors'aime (NCT06489977)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Brucella Spondylitis
Can Hematological Inflammatory Indexes be Used to Differentiate Type 1 Modic Changes From Brucella Spondylodiscitis
Hematological inflammatory indices (Table 2) are currently very popular and have diagnostic, prognostic, and predictive, roles in various diseases.
- Trial name
- NCT06432530
- Testing
- C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), Complete Blood Count (CBC) values, and indexes derived from the CBC.
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Yuzuncu Yil University
Spondylodiscitis
Spondylodiscitis: a Retrospective Observational Study.
Spondylodiscitis is an infectious process affecting the vertebral bodies, intervertebral discs, and paraspinal tissues, sometimes involving the spinal cord, most often with a bacterial etiology.
- Trial name
- SpAl (NCT07164235)
- Testing
- Patients diagnosed with spondylodiscitis
- Where
- Italy
- Volunteers
- 137 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Degenerative Disc Disease, Spondylolisthesis
The European Robotic Spinal Instrumentation (EUROSPIN) Study
In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Recurrent Disc Herniation
- Trial name
- EUROSPIN (NCT03398915)
- Testing
- Transpedicular Instrumentation
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 932 people
- Sponsor
- Marc Schröder
Osteomyelitis; Vertebra, Endocarditis, Bacterial
T2MR PCR Detection of ESKAPE Pathogens in Patients With Pyogenic Spondylodiscitis and Infective Endocarditis
Our prospective observational study focuses on the rapid detection of etiologic agents of pyogenic spondylodiscitis and infective endocarditis using the T2 Bacteria Panel (T2Biosystems).
- Trial name
- NCT05644990
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Spondylodiskitis, Spinal Tumor
Percutaneous Fluoroscopic vs CT Guided Core Needle Biopsy for Spinal Infection and Tumor
Spinal biopsy is important to obtain culture and histopathological diagnosis in spine infection and tumors. To date, there is no prospective randomized study comparing both techniques.
- Trial name
- NCT03585699
- Testing
- Fluoroscopy Guided Spinal Biopsy, CT guided Spinal Biopsy
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- University of Malaya
Vertebral Osteomyelitis, Spondylodiscitis
Immobilization and Neurological Complications in Patients With Vertebral Osteomyelitis.
Vertebral osteomyelitis is an infection of the intervertebral disk and adjacent vertebral plates with a non-negligible risk of neurological complications and handicap.
- Trial name
- SPONDIMMO (NCT04655950)
- Testing
- protocols and practices for the immobilization of vertebral osteomyelitis in different French hospitals and bone and joint infections Centers
- Where
- 9 sites in France
- Volunteers
- 250 people
- Sponsor
- Nantes University Hospital
Infectious; Spondylitis
Prolonged Bed Rest Versus Early Raising in Vertebral Osteomyelitis
Infectious vertebral osteomyelitis are infectious diseases of the vertebral bone, intervertebral disc and/ or adjacent tissue. Most of cases are due to hematogenous dissemination of pathogen but direct inoculation is an aetiology…
- Trial name
- SPONDYL'UP (NCT04735081)
- Volunteers
- 200 people
- Sponsor
- Central Hospital, Nancy, France
Discitis
Unilateral Posterolateral Approach for Spondylodiskitis
This retrospective study assess the efficacy and safety of a posterolateral unilateral approach for debridement and titanium cage insertion supplemented by contralateral transfascial screw fixation for sick patients suffering…
- Trial name
- SPDTIS (NCT03472131)
- Testing
- Unilateral Posterolateral Approach and Debridement, Titanium cage insertion supplemented by screw fixation
- Volunteers
- 20 people
- Sponsor
- University Hospital of Patras
Spondylodiscitis
The Value of PET/CT in Diagnosing Residual Disease in Patients With Spinal Infection
MRI has shoved little correlation with the clinical finding during treatment of spondylodiscitis (infection in the vertebrae and/or discs).
- Trial name
- NCT01542853
- Where
- 3 sites in Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Muscle Atrophy, Postoperative Pain
Post-surgery Muscle Preservation and Pain Reduction Through Blood Flow Restriction Training in Orthopedic Spinal Surgery
This project investigates the effects of the Blood-Flow-Restriction (BFR) training method on postoperative muscle atrophy and pain after spinal surgery. Two groups are formed for this purpose.
- Conditions
- Muscle Atrophy, Postoperative Pain, Spondylolisthesis, Spondylodiskitis
- Trial name
- NCT06962683
- Testing
- Blood-Flow-Restriction Training
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Tuberculosis, Spinal, Tuberculosis, Osteoarticular
Gene Expression Profiles in Spinal Tuberculosis.
Tuberculosis (TB) is one of the top ten causes of death worldwide with approximately 10 million cases globally and 1.2 million deaths. Sub-Saharan Africa carries the highest burden of TB.
- Conditions
- Tuberculosis, Spinal, Tuberculosis, Osteoarticular, Tuberculosis, Mycobacterium Infections
- Trial name
- SpinalTBX (NCT05610098)
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- University of Cape Town
Primary Spondylodiscitis, Pyogenic Spondylodiscitis
One Year Results of Managing Primary Spondylodiscitis
Primary spondylodiscitis is a severe infectious condition involving the spinal discs and adjacent vertebrae. It often causes significant back pain and requires careful management, typically involving long-term antibiotics and…
- Conditions
- Primary Spondylodiscitis, Pyogenic Spondylodiscitis, Spinal Infection
- Trial name
- NCT07509983
- Volunteers
- 50 people
- Sponsor
- Assiut University
Infection, Intervertebral Disc Herniation
Subclinical Propionibacterium Acnes Infection Estimation in the Intervertebral Disc (SPInE-ID)
Subclinical infection of the intervertebral disc after lumbar disc herniation surgery has been correlated to chronic low back pain and vertebral endplate changes. The most commonly reported agent is Propionibacterium acnes.
- Conditions
- Infection, Intervertebral Disc Herniation, Propionibacterium Infection, Spinal Diseases
- Trial name
- SPInE-ID (NCT03158766)
- Testing
- Microdiscectomy
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- Hospital Israelita Albert Einstein