Clinical trials: Disorder Heart
Atrial Fibrillation
Mapping Electrogram Morphology Recurrence for Atrial Fibrillation Ablation
The overall goal of this project is to test the feasibility of performing real-time electrogram morphology recurrence (EMR) mapping in patients with persistent atrial fibrillation (AF) to locate areas of high electrogram…
- Trial name
- NCT03082963
- Testing
- Electrogram Morphology Mapping (EMR)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Jeffrey Goldberger
Heart Failure, HFpEF
Deprescribing Beta-Blockers in Elders With Heart Failure With Preserved Ejection Fraction (DEPRESCRIBE-HFpEF)
The goal of this study is to learn whether stopping beta-blockers can help older adults with heart failure with preserved ejection fraction (HFpEF) feel better and function better.
- Conditions
- Heart Failure, HFpEF, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- DEPRESCRIBE (NCT07298993)
- Testing
- Beta-blockers
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Weill Medical College of Cornell University
Infective Endocarditis
Beta-lactam Pharmacokinetics in Patients With Infective Endocarditis
The recommended length of antibiotic treatment to patients with infective endocarditis is 4-6 weeks. All patients receive the same dosis except for those with renal impairment who receive a smaller dose.
- Trial name
- NCT02033421
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Thyroid Diseases, Heart Diseases
Interest of the SPECT-CT Scan SUVspect in the New Generation of Gamma-cameras With Semiconductor
Since 2017, a revolution began in the departments of nuclear medicine, with the routine use of gamma-cameras with semiconductor.
- Conditions
- Thyroid Diseases, Heart Diseases, Bone Diseases, Brain Diseases
- Trial name
- GAMMA-CAM (NCT03414021)
- Testing
- SPECT-CT Scan
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Lille Catholic University
Aortic Stenosis
PERIGON Japan Trial
The purpose of this study is to evaluate the safety and effectiveness of the 17mm MDT-2215 aortic valve bioprosthesis.
- Trial name
- NCT02686814
- Testing
- 17mm MDT-2215 aortic valve bioprosthesis
- Where
- 10 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Medtronic Cardiac Surgery
Stable Angina (SA), NSTE-ACS (NSTEMI and UA)
Utilisation of Angiox® in European Practice
The objective of this study is to determine utilisation patterns in patients receiving Angiox® in participating European centres.
- Conditions
- Stable Angina (SA), NSTE-ACS (NSTEMI and UA), STEMI (STE-ACS)
- Trial name
- EURO-vision (NCT01011504)
- Where
- 2 sites in France, Germany
- Volunteers
- 2,019 people
- Sponsor
- The Medicines Company
Congestive Heart Failure, Left Ventricular (LV) Systolic Dysfunction
A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System
Treatment of ischemic heart failure.
- Trial name
- PARACHUTE IV (NCT01614652)
- Testing
- CardioKinetix Parachute Implant and All Appropriate Medical Therapy (AAMT)
- Where
- 68 sites in United States, Canada
- Volunteers
- 331 people
- Sponsor
- CardioKinetix, Inc
Congestive Heart Failure, Electric Muscle Stimulation
Electrical Muscle Stimulation in Congestive Heart Failure
This trial is to evaluate two types of electrical muscle Stimulation (EMS) stimulation (low intensity "conventional stimulation" vs.
- Conditions
- Congestive Heart Failure, Electric Muscle Stimulation, Severe Decondition, Elderly Person
- Trial name
- NCT03793647
- Testing
- Electrical muscle devise
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Kantonsspital Olten
Heart Failure, Reduced Ejection Fraction Heart Failure
Personalized IoT-based Physical Activity Monitoring System for Heart Failure Patients
Current literature emphasizes the importance of increasing physical activity, ensuring its continuity, and reducing sedentary behaviors in patients with heart failure (HF).
- Trial name
- IoT-HFActive (NCT07171372)
- Testing
- Device&behavioral
- Volunteers
- 82 people
- Sponsor
- Abant Izzet Baysal University
Acute Myocardial Infarction
MYSTAR-5-YEAR: Long-term Follow-up of Patients With Ischemic Heart Disease Treated With Cell Therapy
The MYSTAR-5-YEAR study controls the patients 5 years after treatment with combined (intramyocardial and intracoronary) delivery of autologous BM-MNCs.
- Trial name
- MYSTAR-5-YEAR (NCT01395212)
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Heart Failure, Left Ventrikular Remodelling
Apical Compression Stitch - a New Option for LV Remodelling
The current study analyses the LV geometry of failing LVs measured by MRI scanning with respect to systolic versus diastolic function.
- Conditions
- Heart Failure, Left Ventrikular Remodelling, Left Ventricular Geometry
- Trial name
- NCT00428467
- Testing
- LV Apex Compression
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Acute Ischemic Stroke, Atrial Fibrillation
Early Versus Late Initiation of Anticoagulation in Mild-to-moderate AIS Patients With NVAF
The goal of this clinical trial is to compare the effectiveness between early and late initiation of anticoagulation therapy in acute ischemic stroke (AIS) patients with non-valvular atrial fibrillation (NVAF).
- Trial name
- ASAP (NCT06057467)
- Testing
- Anticoagulation Agents
- Where
- 2 sites in China
- Volunteers
- 2,351 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease
DES Versus BiOSS LIM - POLBOS II Study
Coronary bifurcation lesions pose therapeutic problems during percutaneous coronary interventions (PCI) and are associated with higher rates of periprocedural complications as well as higher rates of in-stent restenosis and stent…
- Trial name
- POLBOS II (NCT02198300)
- Testing
- Coronary angioplasty with stent implantation, Dual antipletlet therapy (DAPT)
- Where
- Poland
- Volunteers
- 202 people
- Sponsor
- Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Heart Disease, Cancer
Promotora-based Latino Family CVD Risk Reduction
This family environment-focused health behavior change intervention is being carried out by extensively trained community health workers (promotores) familiar with the community in East Los Angeles.
- Trial name
- NCT01714271
- Testing
- Home environs-based lifestyle counseling, Cancer early detection
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Polyneuropathy, Alpha-Synucleinopathy
Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System
Description of a method to detect Parkinson's disease or Parkinson's-like disease at an early stage (Prodromal Parkinson's Disease) where damage is still confined to the peripheral nervous system damage.
- Conditions
- Polyneuropathy, Alpha-Synucleinopathy, Lewy Body Disease, Parkinson Disease (PD)
- Trial name
- Prompark (NCT06745011)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Ventricular Tachycardia (VT), Premature Ventricular Complexes
Severe Complications During Ventricular Tachycardia or Premature Ventricular Complex Ablation
The investigators aim to characterize patients presenting with a severe ventricular tachycardia (VT) and premature ventricular complex (PVC)-ablation-related complication including patient characteristics, procedural details and…
- Trial name
- NCT07777744
- Where
- 25 sites in United States, Austria and 14 more
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Tetralogy of Fallot, Congenital Heart Disease
Tetralogy of Fallot for Life
The aim is to conduct a prospective multi-centre international inception cohort study with an enrollment goal of 3,000 TOF patients and 2 year follow-up post-repair.
- Conditions
- Tetralogy of Fallot, Congenital Heart Disease, Congenital Heart Defect
- Trial name
- TOF-LIFE (NCT02968264)
- Where
- 20 sites in United States, Australia and 10 more
- Volunteers
- 1,108 people
- Sponsor
- Population Health Research Institute
High Bleeding Risk Patients, DAPT(Dual Antiplatelet Therapy)
OCT-based DAPT Cessation in HBR Patients
This study investigates whether patients with diabetes mellitus (DM) and a high risk of bleeding can safely stop dual antiplatelet therapy (DAPT) earlier than usual after receiving a special type of stent called a polymer-free…
- Conditions
- High Bleeding Risk Patients, DAPT(Dual Antiplatelet Therapy), Coronary Artery Disease, Diabetes Mellitus
- Trial name
- NCT07238764
- Testing
- Optical Coherence Tomography-based early DAPT discontinuation
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Postoperative Delirium
Automated Pupillometry in Patients Underwent Cardiac Surgery to Predict Postoperative Delirium
The rate of postoperative delirium in patients who underwent cardiac surgery is very high. Different predictors and/or scores were studied for the prediction of Post Operative Delirium (POD)after heart surgery, but none of them…
- Trial name
- NCT06255132
- Testing
- Automated pupillometer NPi-200
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Microvascular Angina
PRIZE ET Sub-Study
Microvascular angina (MVA) is caused by abnormalities of the small blood vessels in the heart. Endothelin-1 (ET-1) is a chemical messenger that circulates and accumulates in the blood vessel walls, causing them to narrow or go…
- Trial name
- NCT04508998
- Testing
- Blood tests including genotyping, Exercise Tolerance Test
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
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