Clinical trials: Disorder Heart
Unstable Angina Pectoris
Comparison of Administration Strategies of Ticagrelor in Patients With Unstable Angina Pectoris, a Pharmacokinetic / Pharmacodynamic Study
The purpose of this study is to evaluate the differences in pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite depending on the strategy of the drug administration in patients with unstable angina…
- Trial name
- NCT02612116
- Testing
- Pulverized ticagrelor sublingually, Pulverized ticagrelor orally, Integral ticagrelor
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Heart Disease, Heart Failure With Preserved Ejection Fraction
Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a major public health problem that has no proven effective treatment. This study assessed the effects of acute nitrite administration on resting and exercise hemodynamics…
- Conditions
- Heart Disease, Heart Failure With Preserved Ejection Fraction, Exercise Intolerance, Pulmonary Hypertension
- Trial name
- NCT01932606
- Testing
- Nitrite
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Barry Borlaug
Heart Failure
Patient-Reported Outcome Measurement in Heart Failure Clinic
This is a randomized study evaluating the effect of routinely collecting a standardized questionnaire of heart failure health status during heart failure clinic visits.
- Trial name
- PRO-HF (NCT04164004)
- Testing
- Kansas City Cardiomyopathy Questionnaire-12
- Where
- United States
- Volunteers
- 1,249 people
- Sponsor
- Stanford University
Atrial Fibrillation
Assessment of Thrombotic Status in Patients With Atrial Fibrillation
Investigators will assess the impact of treatments for atrial fibrillation on participant's thrombotic status
- Trial name
- NCT02583971
- Volunteers
- 500 people
- Sponsor
- East and North Hertfordshire NHS Trust
Premature Birth
Assessment of Autonomic Regulation During the Listening of Mother Heart Beat in Newborns
Prematurity birth lead to an early breaking link with the in utero environment. A special attention is brought in the neonatal intensive care units to reduce noise and lighting surrounding aiming to protect the newborn.
- Trial name
- Cardio_Sound (NCT04821011)
- Testing
- electronic stethoscope, acoustic listening of mother's heartbeats, Recording of the newborn's heart rate
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Consecutive Incident Adult Patients Undergoing Elective Cardiac Surgery
The Diagnostic Role of Cystein-rich Protein 61 (Cyr61) in Acute Kidney Injury: Correlation With the Harmonic Analysis of Arterial Pressure Pulse Waves.
Acute kidney injury (AKI) is a common heterogeneous disease that complicates several medical and surgical conditions. Recent studies have demonstrated that the occurrence of AKI significantly increase the risk of adverse…
- Trial name
- NCT01876134
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest, Neurologic Dysfunction
Identification of Neuroprognostic Factors for Out-of-hospital Cardiopulmonary Arrest (MIRA29)
From the informatized prehospital care registry, data will be collected anonymously for all patients' requiring cardiopulmonary resuscitation for an out-of-hospital cardiac arrest within the Norther Finistere sanitary region.
- Conditions
- Cardiac Arrest, Neurologic Dysfunction, Cognitive Impairment
- Trial name
- MIRA29 (NCT06569134)
- Where
- 2 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Brest
Atherosclerosis
Incident COronary EveNts Identified by Computed Tomography
The Incident COronary EveNts Identified by Coronary Tomography (ICONIC) trial is a nested, case-control study derived from the dynamic CONFIRM registry, and is based on propensity scoring methods to match subjects with (cases) or…
- Trial name
- ICONIC (NCT02959099)
- Where
- 13 sites in United States, Austria and 6 more
- Volunteers
- 476 people
- Sponsor
- Weill Medical College of Cornell University
Cardiovascular Diseases, Coronary Disease
Post Coronary Artery Bypass Graft (CABG) Study
To determine the relative effectiveness of moderate versus more aggressive lipid lowering, and of low dose anticoagulation versus placebo, in delaying saphenous vein coronary bypass graft atherosclerosis and preventing occlusion…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00000463
- Testing
- lovastatin, cholestyramine, warfarin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation, Anticoagulants; Circulating, Hemorrhagic Disorder
Mhealth Application for anTicoagulation Care in Atrial Fibrillation
This study will assess the benefits of using a mobile health application designed for shared decision aid in anticoagulation therapy in patients with Atrial Fibrillation (AF).
- Trial name
- MATCh AFib (NCT03174093)
- Testing
- MATCh AFib application
- Volunteers
- 200 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Anesthesia
Efficacy of Preemptive Volume Loading to Prevent Arterial Hypotension During Induction of General Anesthesia
Induction of general anesthesia induces frequently arterial hypotension. The short term goal of this study is to evaluate if preemptive volume loading prevents such complication.
- Trial name
- NICOM-MAP (NCT01594021)
- Testing
- Gelatin 500 mL, Gelatin 50 mL
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hopital Foch
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Arrhythmia
To Validate the Specific Patterns of Magnetocardiography, a Non-invasive Non-contact Examination for Patients With Ischemic Heart Disease or Cardiac Arrhythmia
ECG is one of the most important non-invasive method to diagnose CAD and arrhythmia. However, clinically it still has its limitation.
- Trial name
- NCT00965614
- Testing
- MCG
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Renal Impairment
Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
Patients living with diabetes mellitus have double the risk of kidney failure compared to patients without diabetes following use of dye in many x-rays and procedures to diagnose and treat narrowing of the arteries (blood…
- Trial name
- BIOMARKERS (NCT00948116)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Barts & The London NHS Trust
Heart Failure
Avicena LVDP Validation Study
The purpose of the study is to determine the relationship between non-invasive measurement of left ventricular diastolic pressure (LVDP) using the Vivio System, compared with invasively measured LVDP via direct measurement during…
- Trial name
- NCT05633004
- Testing
- Vivio
- Where
- United States
- Volunteers
- 406 people
- Sponsor
- Ventric Health, LLC
Chest Pain, Acute Coronary Syndrome
Use of Determine Learning-based Cardiodynamicsgram (CDG) for Rapid and Precise Stratification of Chest Pain in Emergency Department
Chest pain accounts for 10-20 percent of all emergency department visits. The stratification of chest pain is always a challenge.
- Trial name
- NCT06669884
- Testing
- Cardiodynamicsgram (CDG)
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Qilu Hospital of Shandong University
Heart Failure
Heart Failure and a Preserved Ejection Fraction
This will be a cross sectional study comparing patients with HFpEF and age-matched, non-HF controls recruited from the community.
- Trial name
- NCT00586833
- Testing
- O2 consumption max bike test
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
Heart Failure
Lifestyle Intervention for Heart Failure
The goal of this behavioral research study is to learn if education and training about exercise can help to change the lifestyle of cancer survivors with symptoms of heart failure.
- Trial name
- NCT00633633
- Testing
- Usual Care, Exercise Training, Dietary Counseling
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
Coronary Atherosclerosis, Coronary Artery Calcification
Firefighter Aged Garlic Extract Investigation With CoQ10 as a Treatment for Heart Disease (FAITH)
1. Statement of Problem According to the National Fire Protection Association (NFPA), 43.7% of all firefighters that died on the job experienced sudden cardiac death. The job also affords an incredible amount of stress.
- Conditions
- Coronary Atherosclerosis, Coronary Artery Calcification, Coronary Stenosis
- Trial name
- NCT00860847
- Testing
- Aged garlic extract and Coenzyme Q10
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
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