Clinical trials: Disorder of Vein
Heart Failure, Endothelium
Effect of Urocortins in Patients With Heart Failure
Despite modern advances in treatment, heart failure continues to carry a poor prognosis with high morbidity and mortality rates.
- Trial name
- NCT01599728
- Testing
- Urocortin 2, Urocortin 3 and Substance P
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Venous Insufficiency, Varicose Veins
Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RCT
Varicose veins are a common problem, affecting up to a third of the western adult population. Most suffer with aching, discomfort, pruritis, and muscle cramps, whilst complications include oedema, eczema, lipodermatosclerosis…
- Trial name
- NCT00841178
- Testing
- Surgery, EVLT
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Central Venous Pressure
Correlation of Physical Exam Versus Non-invasive Assessment Versus Invasive Assessment of Central Venous Pressure
The purpose of this study is to establish the accuracy of a non-invasive device that uses near infrared spectroscopy (NIRS) to estimate central venous pressure (CVP) comparing it to physical exam and invasive hemodynamic…
- Trial name
- NCT01574690
- Testing
- Mespere Venus System, Right heart catheterization (RHC), Physical examination of jugular vein
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mespere Lifesciences Inc.
Malaria
Safety and Immunogenicity in Age De-Escalation of PfSPZ Vaccine in Tanzanian Adults, Children, and Infants
The present trial will evaluate safety and tolerability as well as the vaccine-induced humoral and cellular immune responses in healthy Tanzanian adults, adolescents, children, and infants who receive doses of 1.8x10^6, 9.0x10^5…
- Trial name
- NCT02613520
- Testing
- PfSPZ Vaccine, Normal Saline, PfSPZ Challenge (for CHMI)
- Where
- Tanzania
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Colorectal Cancer
Celecoxib, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking blood flow to the tumor and by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00336960
- Testing
- celecoxib, fluorouracil, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Surgery, Central Line Associated Blood Stream Infections (CLABSI)
BIP CVC Clinical Safety and Performance Study
The primary objective of this trial was to determine Bactiguard coated BIP CVC's safety and performance and compare it to corresponding standard uncoated CVC.
- Trial name
- NCT02811380
- Testing
- BIP CVC, Uncoated Standard CVC
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Bactiguard AB
Thrombosis
Low-Dose rtPA to Treat Blood Clots in Major Arm or Neck Veins
This study will test the effectiveness of low-dose recombinant tissue plasminogen activator (rtPA, or alteplase) in dissolving blood clots in major arm or neck veins.
- Trial name
- NCT00055159
- Testing
- Pulse-sprayed injection of recombinant tissue plasminogen activator (rtPA)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Lipodermatosclerosis, Chronic Venous Insufficiency
Copper Impact on Venous Insufficiency and Lipodermatosclerosis
Venous disease has an adverse impact on the quality of life of patients and the NHS spends considerable resources on this chronic condition.
- Conditions
- Lipodermatosclerosis, Chronic Venous Insufficiency, Venous Insufficiency, Varicose Veins
- Trial name
- CIVIL (NCT03283800)
- Testing
- Copper impregnated compression stocking, Normal compression stocking
- Volunteers
- 16 people
- Sponsor
- Croydon Health Services NHS Trust
Skin Lesion, Traumatic Ulcer
Clinical Investigation EUCLIDES-01 for the Calculation of the Area of Skin Lesions
The aim of this clinical investigation is to collect skin lesion area data for the comparison of the agreement among the results obtained between the following three wound area measurement methods: Ruler using the Kundin method…
- Conditions
- Skin Lesion, Traumatic Ulcer, Hematoma, Pressure Ulcer
- Trial name
- NCT05729334
- Testing
- Clinicgram Euclides
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Skilled Skin S.L.
Venous Thrombosis
Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism
The purpose is to evaluate the effects of an investigational blood thinner, apixaban, in preventing venous thromboembolic (VTE) recurrence or death in patients who have completed their intended treatment for deep vein thrombosis…
- Trial name
- NCT00633893
- Testing
- Apixaban
- Where
- 428 sites in United States, Argentina and 27 more
- Volunteers
- 2,711 people
- Sponsor
- Bristol-Myers Squibb
Venous Insufficiency
SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device
The study intends to investigate a novel compression system termed Socknleg composed of an understocking covering the foot with three added stockings extending from the ankle to the knee without covering the foot.
- Trial name
- Socknleg (NCT02621632)
- Testing
- (Socknleg)To done of a novel compression system
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neovascular Age-related Macular Degeneration, Macular Edema
A Study to Evaluate the Usability of the SB11 PFS in Subjects With Wet AMD or Macular Oedema Secondary to RVO
This is a open label, multicenter, Phase II study to evaluate the usability of the pre-filled syringe (PFS) of SB11 (ranibizumab biosimilar).
- Conditions
- Neovascular Age-related Macular Degeneration, Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT06176963
- Testing
- SB11 PFS
- Where
- 3 sites in Poland
- Volunteers
- 34 people
- Sponsor
- Samsung Bioepis Co., Ltd.
Pulmonary Embolism, Proximal Deep Vein Thrombosis
Six Years of Follow-up After Idiopathic Venous Throbmoembolism
Beyond the first 6 months of anticoagulation, patients with a first episode of unprovoked venous thromboembolism have a high risk of recurrence after stopping anticoagulations.
- Trial name
- Padis-Ext (NCT02884934)
- Where
- 10 sites in France
- Volunteers
- 409 people
- Sponsor
- University Hospital, Brest
Heart Failure, Respiratory Insufficiency
A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
The purpose of this study is to evaluate the efficacy and safety of rivaroxaban compared with placebo in the prevention of symptomatic venous thromboembolism (VTE) events and VTE-related death post-hospital discharge in…
- Conditions
- Heart Failure, Respiratory Insufficiency, Stroke Acute, Infectious Diseases
- Trial name
- MARINER (NCT02111564)
- Testing
- Rivaroxaban, 10 mg, Rivaroxaban, 7.5 mg
- Where
- 593 sites in United States, Argentina and 35 more
- Volunteers
- 12,024 people
- Sponsor
- Janssen Research & Development, LLC
Venous Ulcers
Effect of Hyaluronic Acid ECM on Venous Ulcers
The purpose of this pilot study is to compare the incidence and rate of wound healing in subjects with venous ulcers treated with an extracellular matrix composed of hyaluronic acid plus compression therapy as compared to…
- Trial name
- NCT02930499
- Testing
- Hyalomatrix extra-cellular matrix, Mepilex wound dressing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Calvary Hospital, Bronx, NY
Glioma, Malignant
Efficacy and Safety of Rivaroxaban in the Prevention of Venous Thromboembolism in Glioma Patients
Glioma is a common brain tumor with a high risk of venous thromboembolism during treatment, especially in the months after surgery.
- Trial name
- NCT06196918
- Testing
- Rivaroxaban 10 MG
- Where
- 8 sites in China
- Volunteers
- 320 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Atrial Fibrillation, Persistent
Noninvasive 3D Mapping in Persistent Atrial Fibrillation, to Describe Modifications of the Arrhythmogenic Substrate After Pulmonary Vein Isolation and Identify Potential Predicting Factors of Ablation Success
Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults. It is a major cause of ischemic stroke and heart failure.
- Trial name
- CRYOVEST (NCT04229160)
- Testing
- Noninvasive mapping (Cardioinsight® system), long-term cardiac monitoring (LINQ system), Atrial Fibrillation ablation procedure
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Chronic Venous Leg Ulcers
Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers
The primary objective is to evaluate the clinical benefit of CureXcell® as adjunct to Standard of Care in the treatment of Chronic Venous Leg Ulcers.
- Trial name
- NCT02130310
- Testing
- CureXcell®
- Where
- 28 sites in United States
- Volunteers
- 252 people
- Sponsor
- Macrocure Ltd.
Trauma, Venous Thromboembolism
Feasibility Study of Geko vs. IPCs in Trauma
Trauma patients are at a high risk of developing blood clots in the legs (deep vein thrombosis - DVT), which can travel to the lungs and cause serious health consequences.
- Trial name
- GIFT Pilot (NCT01835990)
- Testing
- geko, IPCs
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hamilton Health Sciences Corporation
Liver Metastases
CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer
This is an open label, fixed dose, phase Ib trial of anti-CEA CAR-T cell infusions delivered via the hepatic artery or splenic vein using the Surefire Infusion System (SIS) for patients with CEA-expressing liver metastases or…
- Trial name
- HITM-SURE (NCT02850536)
- Testing
- anti-CEA CAR-T cells
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Roger Williams Medical Center
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