Clinical trials: Dissecting, Aneurysm
Thoracic Aortic Aneurysms, Dissecting, Aneurysm
Endovascular Treatment of Thoracic Aortic Disease
The purpose of this study is to assess the role endovascular therapy to treat aortic disease involving the ascending aorta, the aortic arch, and the visceral segment of the aorta (or thoracoabdominal aorta)
- Conditions
- Thoracic Aortic Aneurysms, Dissecting, Aneurysm, Ascending Aorta Aneurysm, Aortic Arch; Aneurysm, Dissecting
- Trial name
- EVOLVE Aorta (NCT00583817)
- Testing
- Endovascular stent-graft implantation
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Matthew Eagleton
Vascular Disease, Dissection
Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance
An observational, prospective multi-regional post-market registry collecting mid- and long-term data to assess outcomes through ten years of follow-up for subjects treated with GORE® TAG® Conformable Thoracic Stent Graft with…
- Conditions
- Vascular Disease, Dissection, Dissection Aortic Aneurysm, Dissection of Aorta
- Trial name
- TGR 23-02TA (NCT06658730)
- Testing
- Endovascular
- Where
- 37 sites in United States, Denmark and 8 more
- Volunteers
- 1,500 people
- Sponsor
- W.L.Gore & Associates
Dissecting Aneurysm of Cerebral Artery
Registry of Endovascular Treatment for Vertebrobasilar Dissecting Aneurysms in China
The incidence of vertebrobasilar dissecting aneurysms (VBDAs) is about 1/100,000~1.5/100,000, and it is one of the most important causes of stroke in young and middle-aged people.
- Trial name
- VBDAs China (NCT06541106)
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Retinal Detachment, Achilles Tendon
A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events
The purpose of this study is to evaluate whether there is an increased risk of achilles tendon rupture (ATR), retinal detachment (RD) or aortic aneurysm and dissection (AAD) following exposure to fluoroquinolone (FQ) or other…
- Conditions
- Retinal Detachment, Achilles Tendon, Aneurysm, Dissecting
- Trial name
- NCT03479736
- Testing
- Oral Fluoroquinolones (FQ), Other Antibiotics, Febrile Illness Not Treated with Antibiotics Will be Analyzed as an Exposure
- Where
- United States
- Volunteers
- 117,911 people
- Sponsor
- Janssen Research & Development, LLC
Thoracoabdominal; Aortic, Aneurysm, Dissecting
Thoracoabdominal Aortic Stent System for Endovascular Treatment of Thoracoabdominal Aortic Dissecting Aneurysm.
A First in man study to evaluate the safety and efficacy of thoracoabdominal aortic stent system for endovascular treatment of thoracoabdominal aortic dissecting aneurysm.
- Trial name
- NCT05803564
- Testing
- Thoracoabdominal aortic stent system
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Aortic Dissection, Aneurysm, Dissecting
The Branch-based Intraoperative Stent System in the Treatment of Stanford A Aortic Dissection（BROAD）
The purpose of the study was to evaluate the safety and efficacy of a branched type intraoperative stent system for the treatment of Stanford type A aortic dissection
- Conditions
- Aortic Dissection, Aneurysm, Dissecting, Aneurysm, Vascular Diseases
- Trial name
- BROAD (NCT05659641)
- Testing
- PerMed Stent Graft System In Surgical Operation, Endovastec CRONUS® Intraoperative stent system
- Where
- 18 sites in China
- Volunteers
- 259 people
- Sponsor
- Permed Biomedical Engineering Co., Ltd
Dissection Carotid Artery, Dissection Arterial
Next Generation Sequencing Analysis of Patients with Spontaneous Dissection of Cervical Arteries
The goal of this observational study is to analyze the existence of a genetic predisposition in patients with spontaneous dissections of the cervical arteries (SCeAD). The main questions it aims to answer are: 1.
- Conditions
- Dissection Carotid Artery, Dissection Arterial, Dissecting Aneurysm
- Trial name
- NASCeAD (NCT06862063)
- Testing
- Genetic testing
- Where
- Italy
- Volunteers
- 145 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Aortic Arch; Aneurysm, Dissecting
Study of the Thoraflex™ Hybrid Device for the Treatment of Aneurysm/Dissection of the Descending Thoracic Aorta
The purpose of this national observational study is to evaluate the Thoraflex™ Hybrid vascular prosthesis in the replacement of the aortic arch and the treatment of aneurysm/dissection of the descending thoracic aorta in relation…
- Trial name
- NCT03735472
- Testing
- Thoraflex™ Hybrid
- Where
- 37 sites in France
- Volunteers
- 351 people
- Sponsor
- Vascutek Ltd.
Dissecting Aneurysm of Cerebral Artery
Metformin in Patients With Unruptured Vertebrobasilar Dissecting Aneurysms (METTLE)
Vertebrobasilar dissecting aneurysms (VBDAs) are one of the most important causes of stroke in young and middle-aged people, and the natural history of VBDAs is complex and varied, often leading to high rates of disability and…
- Trial name
- METTLE (NCT06405971)
- Testing
- Metformin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ming Lv
Thoracoabdominal Aortic Aneurysm, Thoracoabdominal; Aortic, Aneurysm, Dissecting
Frailty and Physician Modified Fenestrated Endograft for Thoracoabdominal Aortic Pathologies
The primary objective of this single arm, prospective feasibility study, Impact of Frailty on Clinical Outcomes of Patients Treated for Thoracoabdominal and Complex Abdominal Aortic Aneurysms with Physician-Modified Fenestrated…
- Conditions
- Thoracoabdominal Aortic Aneurysm, Thoracoabdominal; Aortic, Aneurysm, Dissecting, Pararenal Aneurysm, Frailty Syndrome
- Trial name
- NCT04524247
- Testing
- Physician Modified Endografts
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California
Aortic Arch; Aneurysm, Dissecting
Guo's Aortic Arch Reconstruction: The First in Man Study of WeFlow-Arch Modular Embedded Branch Stent Graft System
This study is the first in man study of WeFlow-Arch Module Embedded Aorta Arch Stent Graft System
- Trial name
- NCT04764370
- Testing
- WeFlow-Ach Moduler Embedded Branch Stent Graft System
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.
Aortic Aneurysm, Aortic Dissection
Clinical Investigation of Clinical Safety and Performance of the SP-GRIPFLOW, Selective Cerebral Perfusion Catheter When Used for Cerebral Perfusion During Aortic Arch Repair
The purpose of this study is to determine if the SP-GRIPFLOW catheter (the catheter designed by Fuji Systems) is safe and how well it functions.
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Arch Aneurysm, Aortic Arch; Aneurysm, Dissecting
- Trial name
- NCT05421130
- Testing
- Selective Cerebral Perfusion Catheter
- Where
- 5 sites in Germany, Netherlands
- Volunteers
- 149 people
- Sponsor
- Fuji Systems Corporation
Dissecting Aneurysm of Cerebral Artery, Intramural Hematomas
Atorvastatin in the TREATment of Intracranial Unruptured VertebroBasilar Dissecting Aneurysms
This study was designed to whether there is a measurable reduction in inflammation in walls of unruptured vertebrobasilar dissecting aneurysms with atorvastatin.
- Conditions
- Dissecting Aneurysm of Cerebral Artery, Intramural Hematomas, Inflammation Vascular
- Trial name
- ATREAT-VBD (NCT04943783)
- Testing
- Atorvastatin 20mg
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Neurosurgical Institute
Aneurysm, Dissecting, Acute Kidney Injury
Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model
Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death.
- Trial name
- NCT05017896
- Testing
- Normal CT Renal Perfusion imaging indexes, Low CT Renal Perfusion imaging indexes
- Volunteers
- 242 people
- Sponsor
- Qilu Hospital of Shandong University
Chronic Dissecting Aneurysm of Thoracic Aorta, Chronic Nontraumatic Dissection of Thoracic Aorta
Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial
Dexmedetomidine has been known to protect the lung against inflammation and oxidative stress in diverse clinical settings. The investigators aimed to investigate the lung protective effect of dexmedetomidine in patients…
- Conditions
- Chronic Dissecting Aneurysm of Thoracic Aorta, Chronic Nontraumatic Dissection of Thoracic Aorta, Dissecting Aneurysm of the Thoracic Aorta
- Trial name
- NCT02678728
- Testing
- Dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Gangnam Severance Hospital
Dissecting Aneurysm of Cerebral Artery
Dynamic Contrast-Enhanced Magnetic Resonance Imaging Analysis for Prognosis of Intracranial Dissecting Aneurysm With Intramural Hematoma After Endovascular Treatment
This study will evaluate the feasibility to predict the prognosis of IDA with IMH by DCE-MRI and provide theoretical basis for the prognosis and intervention of the disease.
- Trial name
- DEMAT (NCT03940859)
- Testing
- intracranial stent, flow diverter and coils
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Neurosurgical Institute
Aneurysm, Dissecting, Aortic Aneurysm, Thoracic
To Evaluate the Safety and Efficacy for GORE TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Disease
PURPOSE OF RESEARCH: Endovascular stent-graft repair of aortic pathologies is a minimally-invasive alternative to open surgery that may decrease morbidity and mortality, particularly in high risk patients.
- Trial name
- NCT00757003
- Testing
- Endovascular Stent-graft repair of descending thoracic aorta
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Aortic Aneurysm, Thoracic, Aneurysm, Dissecting
A Registry Study on Genetics and Biomarkers of Thoracic Aortic Aneurysm/Dissection
This is a national registry study to determine genetic risk factor and serial biomarkers of thoracic aortic aneurysm/dissection
- Trial name
- ARSGBTAAD (NCT03010514)
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Cerebral Arterial Diseases, Dissecting Aneurysm of Cerebral Artery
Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI
Intracranial artery disease has been more detected with development of HR-MR. HR-MR can depict vascular wall directly and give us more information beyond the pre-existing imaging modalities such as digital subtraction…
- Conditions
- Cerebral Arterial Diseases, Dissecting Aneurysm of Cerebral Artery, Intimal Dissection
- Trial name
- NCT02914288
- Testing
- High resolution magnetic resonance imaging for intracranial vessel walls
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Dissecting Aneurysm of the Thoracic Aorta
Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier
The purpose for this study is to determine if surgery (repair of descending thoracic aneurysm) causes a temporary decrease in the Blood Brain Barrier's ability to remove drugs from the brain back into the blood.
- Trial name
- NCT00878371
- Testing
- morphine
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Nova Scotia Health Authority