Clinical trials: Dopamine
D3 Dopamine Receptor, Cocaine-dependent
Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT
Preclinical work suggests that D3 dopamine receptors may be important in the study of the pathophysiology of affective disorders, psychotic disorders and addiction.
- Conditions
- D3 Dopamine Receptor, Cocaine-dependent, Healthy Volunteer
- Trial name
- NCT02815917
- Testing
- [18F]FTP PET/CT
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Healthy, Caffeine
Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI
This research study aims to determine whether and how caffeine intake affects learning process through reward feedback compared to placebo.
- Conditions
- Healthy, Caffeine, Adenosine, Dopamine D2/3 Receptor Availability
- Trial name
- Caffeine-RAC (NCT06763172)
- Testing
- Caffeine (200 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hsiao-Ying Wey
Decision Making, Executive Function
Dopaminergic Mechanisms Underlying Human Social Behavior
Developing theoretical, quantitative models of the basic cognitive mechanisms underlying human social decision-making, and understanding the influence of neuromodulators such as dopamine on these mechanisms, has important…
- Conditions
- Decision Making, Executive Function, Dopamine
- Trial name
- NCT04205994
- Testing
- Tolcapone 200 MG, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Dopamine Dysregulation Syndrome, Ulcerative Colitis
Effect and Mechanism of Dopamine on Ulcerative Colitis
Increased evidence suggests that dopamine acts as an important regulator of immune function. A substantial amount of dopamine exists in the gastrointestinal tract, especially in colonic lumen.
- Trial name
- NCT05214404
- Testing
- Patients diagnosed with ulcerative colitis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Impulsive Behavior, Impulse Disorders
Clinical Response of Impulsivity After Brain Stimulation in Parkinson's Disease
The objective of this prospective observational cohort study is to answer the following clinically important questions: 1. In patients with a pre-operative history of ICBs, what is the likelihood of improvement or deterioration…
- Conditions
- Impulsive Behavior, Impulse Disorders, Gambling, Pathological, Eating, Binge
- Trial name
- CRIPS (NCT04811807)
- Testing
- Subthalamic Nucleaus Deep brain stimulation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King's College London
Emotions, Motivation
Pramipexole and Emotional Processing
The dopamine agonist pramipexole has recently been suggested as a potential novel antidepressant drug. While preliminary clinical data hint at its efficacy in treating depressive symptoms, our current understanding of its impact…
- Conditions
- Emotions, Motivation, Reward, Dopamine
- Trial name
- PEP (NCT03681509)
- Testing
- Pramipexole
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Opioid Use Disorder, Substance Use Disorders
SMART Brain Health in African-Americans
The investigators hypothesize that opioid use in African-Americans will be associated with hypodopaminergic alleles that alter the threshold for activating feelings of reward and pleasure within the dopaminergic system, and that…
- Conditions
- Opioid Use Disorder, Substance Use Disorders, Dopamine Dysregulation Syndrome, African Americans
- Trial name
- SMART (NCT03861832)
- Testing
- KB220Z
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Howard University
Bulimia Nervosa, Eating Disorders
Neural Response to Catecholamine Depletion in Subjects Suffering From Bulimia Nervosa in Their Past and Healthy Controls
Bulimia nervosa is a severe psychiatric disorder characterized by recurrent binge eating episodes followed by inappropriate compensatory behavior to prevent weight gain such as self-induced vomiting.
- Conditions
- Bulimia Nervosa, Eating Disorders, Dopamine, Reward
- Trial name
- NCT02179814
- Testing
- AMPT/ Demser, Diphenhydramine
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Transcranial Direct Current Stimulation, Dopamine
Effect of the Transcranial Direct Current Stimulation on the Dopaminergic Transmission in Healthy Subjects
Transcranial direct current stimulation (tDCS) is a technique that is emerging as a prospective therapy for neurologic, psychiatric and addictive disorders.
- Trial name
- DOPA-STIM (NCT02402101)
- Testing
- Procedure: active tDCS
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Dopamine Activity, Episodic Memory Consolidation
Dopaminergic Modulation of Cognition and Psychomotor Function
A recent study at our lab showed increased episodic memory consolidation and response readiness after treatment with methylphenidate in healthy volunteers. The investigators seek to replicate and extend these findings.
- Conditions
- Dopamine Activity, Episodic Memory Consolidation, Response Preparation
- Trial name
- NCT01218425
- Testing
- Methylphenidate 40 mg, Levodopa/carbidopa 125 mg, Domperidon 10 mg
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Antipsychotics, Cognition
Change in Brain Metabolism and Cognitive Function by Aripiprazole
Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.
- Conditions
- Antipsychotics, Cognition, Brain Metabolism, Dopamine Receptor Occupancy
- Trial name
- NCT01562808
- Testing
- Aripiprazole
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital