Clinical trials: Dry Eyes
Lipid Tear Deficiency (Disorder), Dry Eye Disease
Changes in Tear Lipid Layer Thickness After Short Exposure to Light Emitting Diode Displays
Video display terminals (VDTs) are ubiquitous, and engagement in digital screens has grown substantially across all age groups worldwide. Prolonged exposure to VDTs is associated with the development of various health problems.
- Trial name
- NCT05003128
- Testing
- LED screen (InnoLux, Taiwan)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Dryness, Dry Eye Syndromes
Prevalence of Different Etiologies of Ocular Dryness in Patients Previously Diagnosed With Dry Eye Disease in A Sample of Egyptian Patients
Proposed Study Title: Prevalence of Different Etiologies of Ocular Dryness in Patients Previously Diagnosed with Dry Eye
- Conditions
- Dryness, Dry Eye Syndromes, Meibomian Gland Dysfunction
- Trial name
- NCT05598437
- Testing
- Dry eye device
- Where
- 2 sites in Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Roweis adel youssef
Amblyopia, Myopia
Performance of a Photoscreener for Vision Screening in a Haitian Pediatric Population
Screening of haitian children between the ages of 3 and 6 years old for amblyogenic risk factors with the use of the Spot photoscreener. The photoscreener results will be compared to the complete ophthalmologic evaluation.
- Conditions
- Amblyopia, Myopia, Hyperopia, Astigmatism
- Trial name
- POPH (NCT02655432)
- Testing
- Spot photoscreener, Ophthalmologic evaluation, Cyclopleged refraction
- Where
- 3 sites in Haiti
- Volunteers
- healthy volunteers welcome
- Sponsor
- Université de Montréal
Dry Eye Disease (DED), Asthenopia
Effect of Smart Phone Reflective Light Film on Dry Eyes and Asthenopia
This study aimed to evaluate the effect of anti-reflection (AR) and circularly polarized (CP) film on video display terminal (VDT) induced dry eye and asthenopia after limited time and close distance of visual tasks under light…
- Trial name
- NCT06992635
- Testing
- using non-processing screens, using AR+CP screens
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dry Eye Syndrome
A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome
To determine the effect of Essential Fatty Acids (EFA's) on Meibomian Gland lipids and aqueous tear production in patients with "dry eyes".
- Trial name
- NCT00344721
- Testing
- Omega-3 fatty acid supplement
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dry Eye Syndromes
Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK).
This study will evaluate and compare 2 artificial tears in their ability to reduce post LASIK dry eye signs and symptoms. The secondary endpoint of this study is to evaluate refractive regression in these patients.
- Trial name
- NCT00620893
- Testing
- PEG- 400 based artificial tear, Systane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Corneal Topography, Dry Eye Syndromes
Performance Evaluation of the OCUTOP Hand-held Corneal Topographer
The OCUTOP is a new hand-held camera that photographs the front of the eye to map the shape of the cornea and to assess the tear film.
- Conditions
- Corneal Topography, Dry Eye Syndromes, Keratoconus, Healthy Volunteers
- Trial name
- OCUTOP (NCT07895849)
- Testing
- OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment)
- Where
- 2 sites in United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Dry Eye Disease, Dry Eye
Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye
Prospective, multicenter, randomized, vehicle-controlled, double-masked, study of CAM-101 topical ophthalmic solution compared to vehicle control followed by crossover to long-term follow-up open-label treatment with CAM-101 for…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- CAMOMILE-2 (NCT06903611)
- Testing
- CAM-101, Vehicle Control
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Cambium Bio Limited
Dry Eye Syndromes
ACCURATE Study for Subjects With Dry Eyes
To determine treatment and imaging outcomes in bilateral ocular surface disease management with an intracanalicular dexamethasone (0.4 mg) insert compared to standard topical over-the-counter artificial tears lubrication…
- Trial name
- ACCURATE (NCT04237012)
- Testing
- Dextenza 0.4Mg Intracanalicular Insert, Over the counter Artificial tears
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Eye Centers of Racine and Kenosha
Dry Eye
Dryness Difference Between Before and After Phacoemulsification
The aim of this study is to compare tear film and tear film secretion before and after phacoemulsificaton cataract surgery
- Trial name
- NCT06513000
- Testing
- Dry eye diagnostic system
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Treatment of Dry Eye Disease
Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease
We propose to investigate the response to Restasis, over a prolonged period of time in heavy computer users with dry eye disease.
- Trial name
- NCT00567177
- Testing
- Restasis, Refresh Plus
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Primary Sjögren Syndrome
Neurotrophins Implications in Primary Sjögren Syndrome
Neurotrophins (NTs) constitute a family of growth factors, which regulated differentiation, proliferation, and survival of both neuronal cells and astrocytes.
- Trial name
- Neuro-SGSp (NCT01081184)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Dry Eye, Eye Strain
Effects of Gunnar Computer Glasses on Viewing Comfort and Performance
The proposed study aims to test if Gunnar computer glasses provide any advantages, in comparison to no glasses, on the following aspects in computer-related office work: Any enhancement on the visual performance of the basic…
- Conditions
- Dry Eye, Eye Strain, Visual Acuity, Color Perception
- Trial name
- NCT02925884
- Testing
- Gunnar OTC Glasses
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Pacific University
Dry Eye
The Beijing Adult Dry Eye Cohort Study
To investigate the prevalence of dry eye in adults in Beijing, and explore the extremely dangerous factors of dry eye in adults in Beijing through two years follow-up, and establish a prediction model of dry eye; On this basis…
- Trial name
- ADEC (NCT06621446)
- Testing
- Comprehensive intervention model
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Dry Eye Disease
Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time
The purpose of the study is to observe lacrimal fluid condition (tear film break-up time) chronologically after a single dose of AL-43546 ophthalmic products（0.15%, 0.25% and vehicle）and 0.1% sodium hyaluronate ophthalmic…
- Trial name
- NCT00760045
- Testing
- Hydroxypropyl Guar Galactomannan, 0.1% sodium hyaluronate ophthalmic solution
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye
The Chronology of Lifitegrast Effect on Anterior Surface Rehabilitation (CLEAR) Study
In patients with dry eye, defined as corneal staining and a reduced tear breakup time, lifitegrast will improve higher order aberrations, ocular scatter index, corneal staining, and TBUT as soon as 1 week after initiating…
- Trial name
- CLEAR (NCT04669561)
- Testing
- Lifitegrast 5% Ophthalmic Solution
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Cataract
Corneal Protect Used During Cataract Surgery
This randomized controlled subject- and examiner-masked study comprised patients scheduled for cataract surgery.The patients will be randomly assigned to receive either balanced salt solution（BSS）or hydroxypropyl…
- Trial name
- CPUDCS (NCT02363530)
- Testing
- Hydroxypropyl ethylcellulose (HPMC) 2% gel, BSS
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy Volunteer, Sjogren's Syndrome
Characterization of Diseases With Salivary Gland Involvement
Background: Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life.
- Conditions
- Healthy Volunteer, Sjogren's Syndrome, Salivary Gland Disease
- Trial name
- NCT02327884
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Age Related Macular Degeneration
Carbidopa-Levodopa in Dry AMD With Geographic Atrophy
From 3 large patient databases, patients diagnosed with AMD who have never taken levodopa(L-DOPA) containing medications have a mean age of diagnosis at 71 years.
- Trial name
- NCT03451500
- Testing
- carbidopa-levodopa
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Snyder, Robert W., M.D., Ph.D., P.C.
Dry Eye
Comparison of the Clinical Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome
With the potential to address evaporative dry eye, Liposic and Tears Naturale Forte have been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid.
- Trial name
- NCT02992392
- Testing
- Liposic, Tears Naturale Forte
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University