Clinical trials: Durability
Multiple Myeloma
UARK 2006-15: A Study of Tandem Transplants With or Without Bortezomib and Thalidomide
Add three drugs, bortezomib, thalidomide, and dexamethasone (VTD) to the high dose chemotherapy regimen immediately before transplant (DPACE/Melphalan) to try to improve myeloma response and acquire longer survival for…
- Trial name
- NCT00574080
- Testing
- Interim/Maintenance Dexamethasone, Induction/Consolidation Dexamethasone, Induction/Consolidation Cisplatin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas
Healthy Subjects
Study to Characterize the Durability of Hypertonic Saline to Enhance Mucociliary Clearance in Healthy Subjects
The purpose of this research study is to learn about how long hypertonic saline (HS) works in healthy subjects. Inhaled hypertonic saline is one of the medications used to treat Cystic Fibrosis (CF).
- Trial name
- NCT01617369
- Testing
- Hypertonic Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Neovascular Age-related Macular Degeneration (nAMD)
A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration
This study is a Phase IIIb/IV, multicenter, randomized, two-arm, open-label 100-week study to investigate the efficacy, safety, and durability of intravitreal 6-mg faricimab administered at up to 24-week intervals in patients…
- Trial name
- CONSTANCE (NCT06795048)
- Testing
- Faricimab
- Where
- 67 sites in United States, Australia and 10 more
- Volunteers
- 274 people
- Sponsor
- Hoffmann-La Roche
Tooth Discoloration, Tooth Staining
Peroxide Versus Non-Peroxide In-Office Tooth Bleaching
This randomized clinical trial aims to compare the effectiveness of peroxide and non-peroxide in-office tooth bleaching systems.
- Trial name
- BECTS (NCT07818031)
- Testing
- peroxide -based in office tooth bleaching, non-peroxide -based in office tooth bleaching
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Minia University
Metabolic Acidosis
Long-term Safety Extension to Study TRCA-301
This study is a 40-week, blinded, placebo-controlled extension of Study TRCA-301 (NCT03317444). Eligible subjects who complete the 12-week treatment period in Study TRCA-301 have the option to participate in this extension study…
- Trial name
- NCT03390842
- Testing
- TRC101
- Where
- 29 sites in United States, Bulgaria and 5 more
- Volunteers
- 196 people
- Sponsor
- Tricida, Inc.
Bacteria, Microbiota
Standardized Fecal Microbiota Transplantation for Ulcerative Colitis
The gut microbiota is considered to constitute a "microbial organ" which has pivotal roles in the intestinal diseases and body's metabolism.
- Conditions
- Bacteria, Microbiota, Fecal Microbiota Transplantation, Inflammatory Bowel Disease
- Trial name
- NCT01790061
- Testing
- Standardized FMT, Traditional treatments
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Prosthesis Durability
Evaluation of Locator Versus TITACH Attachment for Mandibular Overdentures.
The purpose of this randomized controlled clinical study was to evaluate the locator and TITACH attachments used for retaining mandibular 2-implant overdentures regarding retention , bite force and implant marginal bone loss…
- Trial name
- NCT06228859
- Testing
- overdentures with different attachments
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Diabetic Macular Edema (DME)
A Phase 3 Trial for Intravitreal Injection of 4D-150 in Adults With Diabetic Macular Edema (DME).
A Phase 3, Randomized, Double-Masked, Active-Controlled Trial to Evaluate the Safety, Efficacy, and Durability of a Single Intravitreal Injection of 4D-150 versus Aflibercept in Adults with Diabetic Macular Edema (4SIGHT)
- Trial name
- 4SIGHT (NCT07867080)
- Testing
- 4D-150 IVT (3x10^10 vg), EYELEA ® (aflibercept) Injection 2 mg (0.05mL)
- Where
- 87 sites in United States, China and 1 more
- Volunteers
- 514 people
- Sponsor
- 4D Molecular Therapeutics
Traumatic Brain Injury, Post-Concussive Symptoms
Long-Term Outcomes Following HBOT
This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear…
- Conditions
- Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
- Trial name
- NCT07732374
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Summit Hyperbarics and Wellness
Brow Ptosis, Dermatochalasis
Enhancing the Durability of Thread-Assisted Brow Suspension Through Upper Blepharoplasty-Assisted Ligament Release
This prospective clinical study aims to investigate whether combining upper blepharoplasty with limited release of the lateral brow-retaining ligaments improves the long-term effectiveness of barbed thread brow suspension.
- Conditions
- Brow Ptosis, Dermatochalasis, Periorbital Aging
- Trial name
- NCT07879456
- Testing
- Upper Blepharoplasty, Barbed Thread Brow Suspension, Lateral Brow-Retaining Ligament Release
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Muhammed Mustafa Demirok
Prosthesis Durability, Prosthesis User
A Sensorimotor Prosthesis for the Upper Limb
The finger and fingertip are the most frequently amputated body parts, due to work-related incidents. Yet because of space, weight and cost constraints, prosthetic fingers and fingertips are heavy and bulky with limited active…
- Conditions
- Prosthesis Durability, Prosthesis User, Amputation, Amputation; Traumatic, Hand
- Trial name
- PROLIMB (NCT05220553)
- Testing
- PROLIMB Prosthesis
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Aortic Valve Stenosis
Inspiris Resilia Durability Registry
Prospective, open-label, multicenter, European registry with a follow-up of 5 years to assess the clinical outcomes of patients younger than 60 years who undergo surgical AVR with the INSPIRIS RESILIA Aortic Valve™.
- Trial name
- INDURE (NCT03666741)
- Testing
- AVR with or without CABG
- Where
- 21 sites in Austria, Belgium and 7 more
- Volunteers
- 400 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
HIV-1 Infection
Study to Assess the Safety and Durability of Viral Control Beyond 24 Weeks of Analytical Treatment Interruption After the Administration of Candidate HIV-1 Vaccines DNA.HTI, MVA.HTI and ChAdOx1.HTI or Placebo in Early Treated HIV-1 Positive Individuals (ATI Extension of AELIX-002 Study)
The AELIX-002 trial has been conducted on a cohort of individuals who started cART within the first 6 months after the primary VIH infection, thus increasing the likelihood of observing a certain rate of post-treatment controls…
- Trial name
- NCT04385875
- Testing
- Vaccine + extension of the ATI period
- Where
- Spain
- Volunteers
- 6 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
A Combination of Adoptive T Cell Therapy and Ipilimumab Could Increase the Proportion of CR Patients, and Durability of Response
Clinical Evaluation of Yervoy in Combination With Adoptive T Cell Transfer for Metastatic Melanoma Patients
A rationally designed combination of adoptive T cell therapy and ipilimumab could strongly increase the proportion of CR patients, as well as the durability of response, as compared to ipilimumab or TIL alone.
- Trial name
- NCT01988077
- Testing
- Adoptive cell transfer, Ipilimumab 5 MG/ML Injection [Yervoy]
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Sheba Medical Center
Hand Hygiene Compliance, Hand Hygiene Effectiveness
Fluorescent Hand Hygiene Training and Long-Term Effects in First-Year Nursing Students
This single-group quasi-experimental study will evaluate the effectiveness and durability of a fluorescent hand hygiene training program for first-year nursing students at a Polish university.
- Conditions
- Hand Hygiene Compliance, Hand Hygiene Effectiveness, Hand Hygiene, Hand Hygiene Behavior
- Trial name
- NCT07759037
- Testing
- Fluorescent Hand Hygiene Training with Glo Germ
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Powiślańska Academy of Applied Sciences
Mitral Valve Disease
Durability at 20 Years of Quadrangular Resection With Annular Plication for Mitral Regurgitation
Degenerative mitral regurgitation (MR) due to prolapse of the posterior leaflet is the most common dysfunction of the mitral valve (MV) in the Western world and is nowadays treated with a variety of surgical techniques.
- Trial name
- NCT05724537
- Testing
- Quadrangular resection and annular plication
- Where
- Italy
- Volunteers
- 145 people
- Sponsor
- Michele De Bonis
Prosthesis Durability
Impact of Mandibular Overdenture Base Construction Techniques on Assessment of Occlusion
This within patient study will be conducted to compare between two different construction techniques (CAD-CAM Milled and Conventional techniques) of 4-implant-assisted complete mandibular overdenture bases regarding the digital…
- Trial name
- NCT06080815
- Testing
- CAD/CAM Complete denture
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Type 2 Diabetes
Exenatide Plus Pioglitazone Versus Insulin in Poorly Controlled T2DM
To compare efficacy, safety and durability of combination therapy with pioglitazone plus GLP-1 RA versus basal bolus insulin in poorly controlled T2DM patients on metformin plus sulfonylurea
- Trial name
- NCT02887625
- Testing
- Pioglitazone plus exenatide, insulin glargine and insulin aspart
- Where
- Qatar
- Volunteers
- 410 people
- Sponsor
- Dr. Muhammad Abdulghani
HIV Infections
A 48-Week, Randomised, Study to Describe the Pharmacokinetic Profile and Durability of Atazanavir-Saquinavir-Ritonavir Once Daily and Describe the Pharmacokinetic Profile of Saquinavir-Ritonavir Using Saquinavir 500mg Formulation: the ASK-500 Study
Saquinavir and Atazanavir are drugs used in combination therapy to treat HIV disease. Saquinavir is currently available in a 200 milligram capsule. Most individuals currently on saquinavir require to take 5 tablets twice a day.
- Trial name
- ASK-500 (NCT00192608)
- Testing
- saquinavir 500 formulation, cross-over arm
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Kirby Institute
Dentin Hypersensitivity
Effect of Diode Laser on Sensitive NCCLs Prior to Composite Restoration, Dentin Bonding, and Clinical Durability of Composite Restorations.
This study will investigate the efficacy of three diode laser wavelengths 445 nm, 660 nm, 970 nm when applied just before placement of composite restoration on reducing postoperative sensitivity from Non-carious cervical lesions…
- Trial name
- NCT05501691
- Testing
- 445 nm Diode Laser Wavelength, 660 nm Diode Laser Wavelength, 970 nm Diode Laser Wavelength
- Where
- Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Alexandria University