Clinical trials: Dyspnea; Cardiac
Acute Decompensated Heart Failure
Low Level Tragus Stimulation in Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a major cause of morbidity and mortality. It is associated with increased systemic inflammation.
- Trial name
- TREAT-HF (NCT02898181)
- Testing
- Neuromodulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Oklahoma
Hypertrophic Cardiomyopathy
Ranolazine for the Treatment of Chest Pain in HCM Patients
The purpose of RHYME is to evaluate the safety and efficacy of ranolazine in Hypertrophic Cardiomypathy patients with chest pain or dyspnea despite treatment with standard medical therapy.
- Trial name
- RHYME (NCT01721967)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Heart Failure, Breathing Exercises
Breathing Exercises for Dyspnea and Anxiety in Heart Failure
Heart failure is a leading cause of emergency department admissions, with dyspnea and psychological distress being among the most common presenting symptoms.
- Conditions
- Heart Failure, Breathing Exercises, Dyspnea, Anxiety
- Trial name
- NCT07752706
- Testing
- Diaphragmatic and Pursed-Lip Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Istanbul University - Cerrahpasa
Dyspnea
Artificial Intelligence to Improve Physicians' Interpretation of Chest X-Rays in Breathless Patients
Identifying the cause of breathlessness in acute patients in the emergency department is critical and challenging. The chest X-ray is central but challenging to read for non-radiologist physicians.
- Trial name
- XRAI (NCT05117320)
- Testing
- AI support
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
COVID-19 Pandemic, Diabetes
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19
The COVID-19 pandemic has emerged as the most significant public health crisis of the 21st century. As of the end of January 2023, global confirmed cases have exceeded 670 million, with a domestic cumulative total of 10.24…
- Conditions
- COVID-19 Pandemic, Diabetes, Hypertension, Cardiac Disease
- Trial name
- NCT06231225
- Testing
- Incentive Spirometer respiratory training
- Volunteers
- 100 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Heart Failure, Congestive Cardiac Failure
B-type NAtriuretic Peptide In Critically Ill : A Multicentric Diagnostic Study (B-rAPID)
Difficulty in breathing or increased rate of breathing are common causes of admission to intensive care unit. This may be due to heart failure, or other causes such as infection in the lungs.
- Conditions
- Heart Failure, Congestive Cardiac Failure, Dyspnoea
- Trial name
- B-RAPID (NCT01685385)
- Testing
- Patients who will receive the BNP test
- Where
- 4 sites in India
- Volunteers
- 800 people
- Sponsor
- Mahatma Gandhi Institute of Medical Sciences
Heart Failure, Congestive, Dyspnea
The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure
The purpose of this study is to test the hypothesis that treatment with oral ALT-711 twice daily for 16 weeks will improve aortic distensibility, exercise tolerance, and quality of life in elderly patients with isolated diastolic…
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00043836
- Testing
- ALT-711
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Synvista Therapeutics, Inc
COVID-19, Heart Rate
Effect of Mask Use on Hemodynamic Responses During Exertion
The use of masks is a necessity due to the current pandemic conditions. The aim of the study is to examine the effects of the use of masks during effort on dyspnea and fatigue with hemodynamic parameters.
- Conditions
- COVID-19, Heart Rate, Blood Pressure, Exercise Test
- Trial name
- NCT05401331
- Testing
- Treadmilll, mask
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Covid19, Cardiopulmonary Disease
Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated.
- Conditions
- Covid19, Cardiopulmonary Disease, Dyspnea, Lung Function Decreased
- Trial name
- NCT04859894
- Testing
- Physiological testing
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Family Palliative and End-of-Life Care for Advanced Heart Failure
Overall objective is to test whether the 5-weekly family home palliative and end-of-life care (FamPALcare) intervention educational and supportive sessions will improve rural home end-of-life and palliative care (EOLPC) for…
- Trial name
- NCT04153890
- Testing
- FamPALcare
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- West Virginia University
Cardiac Ischemia, Chest Pain
Myocardial Ischemia Detection for Early Identification of Patients With Ischemic Chest Pain
The purpose of this study is to evaluate whether new novel markers from the clinical electrocardiogram (EKG), which have been used as non-invasive measures of heart disease, can detect coronary artery disease in patients with…
- Conditions
- Cardiac Ischemia, Chest Pain, Shortness of Breath
- Trial name
- MID-EPIC (NCT02055443)
- Testing
- 12-lead holter monitor application
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Dyspnea, Heart Failure
Registry of Patients With Acute Dyspnea in the Emergency Department
This is a prospective registry of patients presenting with acute dyspnea to the emergency department of the city hospital in Nuremberg.
- Conditions
- Dyspnea, Heart Failure, COPD
- Trial name
- NCT01910233
- Where
- Germany
- Volunteers
- 947 people
- Sponsor
- Klinikum Nürnberg
Chronic Heart Failure, Heart Decompensation
Early-start Exercise Training in Subacute Heart Failure
The purpose of this study is to evaluate the feasibility and the short-term effects of an early-start aerobic exercise training program on functional capacity, symptoms and neurohormonal activation in chronic heart failure…
- Trial name
- RE-START (NCT02051985)
- Testing
- Aerobic exercise training, Standard physical therapy
- Where
- 9 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Salvatore Maugeri
Heart Failure, Cardiovascular Disease
Use of Nesiritide in the Management of Acute Diastolic Heart Failure
Primary objective is to assess the effect of nesiritide in decreasing left ventricular (LV) filling pressure, defined as pulmonary artery capillary wedge pressure (PCWP) in a group of patients admitted with acute diastolic heart…
- Conditions
- Heart Failure, Cardiovascular Disease, Acute Heart Failure, Diastolic Heart Failure
- Trial name
- NCT00083772
- Testing
- Nesiritide
- Volunteers
- 9 people
- Sponsor
- M.D. Anderson Cancer Center
Congestive Heart Failure
Cardiac Resynchronization Therapy, Dyspnea and Exercise Tolerance in Patients With Congestive Heart Failure (CHF)
A new therapy for patients with advanced heart failure (HF) involves the implantation of a specialized pacemaker device (Cardiac Resynchronization Therapy, CRT) that attempts to restore the synchronized contraction of the…
- Trial name
- NCT00700700
- Testing
- Active Cardiac Resynchronization Therapy (CRT)
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Queen's University
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Calibration Study PREDICT - Prehospital Triage for Suspected Acute Coronary Syndrome Without ST-segment Elevation
The PREDICT calibration study is a prospective, non-interventional trial aiming to adapt and calibrate the ACS-Pathfinder algorithm for prehospital triage of patients with suspected non-ST-elevation acute coronary syndrome…
- Trial name
- PREDICT (NCT07419139)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Leipzig Heart Science gGmbH
Heart Diseases
Pain Assessment, Incidence & Nature in Heart Failure
Heart failure, a chronic illness afflicting 5 million persons in the United States is known to cause shortness of breath and fatigue, yet at least half of persons with heart failure also report the presence of pain.
- Trial name
- PAIN-HF (NCT00444301)
- Where
- 14 sites in United States
- Volunteers
- 349 people
- Sponsor
- PC-HEART
Acute Heart Failure, Dyspnea
Improving Diagnostic Accuracy for Acute Heart Failure
Acute heart failure is a common reason for emergency department visits and hospitalization, but the diagnosis can be challenging because of non-specific symptoms and signs.
- Conditions
- Acute Heart Failure, Dyspnea, Dyspnea; Cardiac
- Trial name
- INDICATE-HF (NCT04886128)
- Where
- United States
- Volunteers
- 2,469 people
- Sponsor
- Vanderbilt University Medical Center
Heart Failure, Congestive, Heart Decompensation
A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment of Patients With Worsening Congestive Heart Failure Who Require Inpatient Intravenous Therapy With Medications That Influence the Tone and Caliber of Blood Vessels
The purpose of this safety study is to evaluate NATRECOR® hBNP (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure), in subjects with worsening congestive heart failure…
- Trial name
- NCT00271557
- Testing
- nesiritide
- Volunteers
- 305 people
- Sponsor
- Scios, Inc.
Heart Failure, Congestive
FUSION I Assesses Safety and Tolerability of Two Doses of NATRECOR (Nesiritide) Administered to Patients With Worsening Congestive (Decompensated) Heart Failure Who Are Concurrently Receiving Their Usual Cardiac Medications and Are at High Risk for Hospitalization.
The purpose of this study is to assess the safety and tolerability of two doses of nesiritide (a recombinant form of the natural human peptide normally secreted by the heart in response to heart failure) when administered…
- Trial name
- NCT00270361
- Testing
- nesiritide, usual long term cardiac medications
- Volunteers
- 214 people
- Sponsor
- Scios, Inc.