Clinical trials: Dystonia, Cervical
Cervical Dystonia
Long-term Outcome of DBS Versus Botulinum Toxin Treatment in Cervical Dystonia
Cervical dystonia (CD) is the most common isolated dystonia in adults. Cervical dystonia symptoms can in most patients be managed well by botulinum toxin (BTX) injections, and supporting treatment measures.
- Trial name
- NCT04432285
- Testing
- DBS-device, implanted in GPi bilaterally, Botulinum toxin
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Cervical Dystonia
Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia.
The purpose of the protocol is to evaluate the efficacy and safety of Dysport® using 2 mL dilution compared with placebo for the treatment of Cervical Dystonia.
- Trial name
- NCT01753310
- Testing
- Botulinum toxin type A
- Where
- 42 sites in United States
- Volunteers
- 134 people
- Sponsor
- Ipsen
Cervical Dystonia
Clinical and Kinematic Assessment for Determination of Botox® Injection Parameters in Cervical Dystonia
This study investigates the use of a kinematic measurement device to quantify the abnormal head movements and postures in patients with cervical dystonia (CD) in order to individualize and optimize botulinum toxin type A (BoNT-A)…
- Trial name
- NCT02662530
- Testing
- Botulinum Toxin Type A
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Western University, Canada
Cervical Dystonia
Extension Study of ABP-19000 to Evaluate Safety and Efficacy of Repeat Treatments of ABP-450 in Cervical Dystonia
This Open-label Extension trial will evaluate the safety and efficacy of ABP-450 for the treatment of cervical dystonia in adults.
- Trial name
- NCT04871451
- Testing
- ABP-450
- Where
- 20 sites in United States
- Volunteers
- 51 people
- Sponsor
- AEON Biopharma, Inc.
Cervical Dystonia
IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Cervical Dystonia
At baseline patients received incobotulinumtoxinA (Xeomin) or placebo. Thereafter, all patients who entered the extension period were treated with up to five injection sessions of incobotulinumtoxinA (Xeomin) during the extension…
- Trial name
- NCT00407030
- Testing
- incobotulinumtoxinA (Xeomin) (240 Units), incobotulinumtoxinA (Xeomin) (120 Units)
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Merz Pharmaceuticals GmbH
Cervical Dystonia, Blepharospasm
Trial Evaluating Xeomin® (incobotulinumtoxinA) for Cervical Dystonia or Blepharospasm in the United States
This is a prospective, observational trial evaluating the "real world" use of Xeomin®(incobotulinumtoxinA). Physicians may enroll patients who are eligible to be treated with a botulinum toxin for cervical dystonia or…
- Trial name
- XCiDaBLE (NCT01287247)
- Testing
- Xeomin®
- Where
- 70 sites in United States
- Volunteers
- 688 people
- Sponsor
- Merz North America, Inc.
Cervical Dystonia
Longitudinal Study for Treatment With Botulinum Toxin A Injections in naïve and Pre-treated Patients Suffering From Cervical Dystonia [CD-NIS-Longterm]
The objective of this study is to investigate the efficacy of Dysport® in the treatment of cervical dystonia (CD) in a non-interventional long-term study in naïve and pre-treated patients.
- Trial name
- CDNISLongterm (NCT01840462)
- Where
- 2 sites in Austria, Germany
- Volunteers
- 372 people
- Sponsor
- Ipsen
Cervical Dystonia
Phase IV-Cervical Dystonia-INTEREST IN CD2
The purpose of the study is to document long-term response in real-life practice after injection cycles with BoNT-A in subjects suffering from idiopathic cervical dystonia (Long-term clinical and pharmaco-economic data).
- Trial name
- INTEREST_INCD2 (NCT01753349)
- Testing
- Botulinum toxin type A
- Where
- 113 sites in United States, Algeria and 32 more
- Volunteers
- 1,050 people
- Sponsor
- Ipsen
Cervical Dystonia
Double-blind, Multicenter Study to Assess the Efficacy of Bilateral Pallidal Stimulation in Patients With Medically Refractory Primary Cervical Dystonia
The purpose of this study is to investigate the efficacy and safety of bilateral pallidal stimulation in patients with medically refractory primary cervical dystonia.
- Trial name
- NCT00148889
- Testing
- Deep brain stimulation (DBS)
- Where
- 10 sites in Austria, Germany
- Volunteers
- 63 people
- Sponsor
- German Parkinson Study Group (GPS)
Cervical Dystonia
Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1)
This is a randomized, double-blind, placebo-controlled, parallel group, multi-center trial of two doses of daxibotulinumtoxinA (DAXI) for injection (high-dose; low-dose in adult subjects with isolated (primary) cervical dystonia…
- Trial name
- ASPEN-1 (NCT03608397)
- Testing
- DaxibotulinumtoxinA for injection
- Where
- 75 sites in United States, Austria and 7 more
- Volunteers
- 301 people
- Sponsor
- Revance Therapeutics, Inc.
Cervical Dystonia
Study for Determine the Safety and Efficacy of Clostridium Botulinum Toxin Type A in Subjects With Cervical Dystonia
The purpose of this study is to determine the Optimal dose for safety and efficacy in the treatment of cervical dystonia.
- Trial name
- NCT01588574
- Testing
- MT10109, BOTOX(Registered trade mark)
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Medy-Tox
Cervical Dystonia
A Multicenter Pilot Study of Pallidal Deep Brain Stimulation for Cervical Dystonia
The purposes of this study are: to determine if bilateral pallidal deep brain stimulation results in improvement in neck postures/movements; to determine if bilateral pallidal deep brain stimulation results in improvement in…
- Trial name
- NCT00132990
- Testing
- Deep brain stimulation
- Where
- 5 sites in Canada
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Cervical Dystonia
A Phase 2 Study to Evaluate the Safety and Efficacy of ABP-450 in the Treatment of Cervical Dystonia
This Phase 2 trial will evaluate the safety and efficacy of ABP-450 for the treatment of cervical dystonia in adults. The study will enroll 60 patients across approximately 30 sites in the United States.
- Trial name
- NCT04849988
- Testing
- ABP-450
- Where
- 21 sites in United States
- Volunteers
- 61 people
- Sponsor
- AEON Biopharma, Inc.
Cervical Dystonia
Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia
The purpose of this research study is to determine the physical brain changes in people with cervical dystonia after deep brain stimulation (DBS) surgery and as compared to healthy controls.
- Trial name
- NCT01671527
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cervical Dystonia
Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS)
Phase 3, open-label, multi-center trial to evaluate the long-term safety, efficacy, and immunogenicity of up to four continuous treatment cycles of daxibotulinumtoxinA (DAXI) for injection.
- Trial name
- ASPEN-OLS (NCT03617367)
- Testing
- daxibotulinumtoxinA for injection
- Where
- 65 sites in United States, Austria and 7 more
- Volunteers
- 357 people
- Sponsor
- Revance Therapeutics, Inc.
Dystonia
Deep Brain Stimulation in Patients With Dystonia
The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN)for primary dystonia.
- Trial name
- STN DBS (NCT00773604)
- Testing
- Medtronic implantable deep brain stimulation (DBS) system
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Psychogenic Dystonia
Heart Rate Variability Biofeedback Training in Psychogenic Disorders
To study whether Heart Rate Variability (HRV) biofeedback training can improve abnormal head posture and painful symptomatology in patients with "cervical dystonia" not selected for DBS after extensive screening in a specialized…
- Trial name
- ECoDys (NCT04777825)
- Testing
- Heart rate variability biofeedback training (Symbiocenter), psychoeducation session
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Cervical Dystonia
A Study to Compare Dysport® and Botox® in the Treatment of Cervical Dystonia
1. to examine the non-inferiority of Dysport in the clinical efficacy and safety in comparison with Botox®, assuming a bioequivalence ratio of 2.5:1 units, in the treatment of Cervical dystonia. 2.
- Trial name
- NCT00950664
- Testing
- Dysport® (abobotulinumtoxinA), Botox® (onabotulinumtoxinA)
- Where
- 7 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Seoul National University Hospital
Cervical Dystonia
Safety and Tolerability of Perampanel in Cervical Dystonia
Cervical dystonia (CD) is the most common focal dystonia. Currently there are no effective oral medications for the treatment of CD.
- Trial name
- SAFE-PER-CD (NCT02131467)
- Testing
- Perampanel
- Where
- 5 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Cervical Dystonia
Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex
This study will compare Xeomin®, a botulinum toxin medication, in shorter treatment intervals (Short Flex dosing) to the standard interval dosing (Long Flex dosing) to determine if the response to treatment is comparable in both…
- Trial name
- NCT01486264
- Testing
- Xeomin®
- Where
- 43 sites in United States
- Volunteers
- 283 people
- Sponsor
- Merz Pharmaceuticals GmbH