Clinical trials: Dystonia
Plagiocephaly
Newborn Head Molding and Later Asymmetries
Prospective randomized clinical interventional trial after birth in maternity ward, and follow up to 8-9 years of age. Hypothesis: Preventive handling and caring advices to parents of newborns decrease craniofacial asymmetries…
- Trial name
- NCT02283229
- Testing
- Newborns with preventive caring advices, Newborns with normal caring advices
- Where
- Finland
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Cervical Dystonia
Static Graviceptive Functions in Patients With Cervical Dystonia (CD)
The purpose of this experimental pilot study is to test the effect of normalization of the head position on the sense of balance at patients with cervical dystonia under routine botulinum toxin treatment.
- Trial name
- NCT01180270
- Where
- Austria
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kirsten Elwischger
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Oromandibular Dystonia, Cranial Dystonia
Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia
Background: People with dystonia cannot control their muscle contractions. This disorder can affect different body areas. When it affects the face, tongue, and jaw, it is called oromandibular dystonia (OMD) or cranial dystonia…
- Trial name
- NCT02199509
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease, Tremor
Using DBS to Probe Basal Ganglia Dysfunction
This study will probe the function of collections of neurons deep in the brain termed the basal ganglia It will investigate the role of the basal ganglia in how and why movement is disrupted in conditions like Parkinson's…
- Conditions
- Parkinson's Disease, Tremor, Dystonia
- Trial name
- NCT04080674
- Testing
- Feed-back controlled deep brain stimulation
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Dystonia, Primary Generalized Dystonia
Bilateral Internal Pallidum Stimulation in Primary Generalized Dystonia
Primary generalized dystonia, also called idiopathic torsion dystonia or dystonia musculorum deformans is a disabling neurological condition which usually starts in childhood, mostly in a lower limb and spreads to other body…
- Trial name
- NCT00272246
- Testing
- deep brain stimulation of the internal globus pallidus
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Secondary Dystonia, Cerebral Palsy, Mixed
The Effect of Dystonia Severity on Participation in Daily Living Activities and Caregivers in Children of Cerebral Palsy With Secondary Dystonia
Dystonia is the most common movement disorder in the pediatric population after spasticity. It can affect normal motor development and cause significant motor retardation.
- Trial name
- NCT06307561
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Acıbadem Atunizade Hospital
Dystonia
Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp
Objective: Writer s cramp (WC) is a form of focal hand dystonia (FHD). Focal injections of botulinum toxin (BoNT) are the current best therapy. Past studies showed that some types of rehabilitative therapy can be useful.
- Trial name
- NCT02015039
- Testing
- BoNT Injections, Occupational Therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Post Stroke Spasticity, Dystonia
Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.
The aim of this clinical trial is to determine whether deep brain stimulation (DBS) interventions improve rehabilitation and functional recovery in patients with post-stroke spasticity who meet the other inclusion criteria listed…
- Trial name
- NCT07190092
- Testing
- Deep brain stimulation electrode implantation with an electrode target in the dentate nucleus
- Where
- Poland
- Volunteers
- 12 people
- Sponsor
- Jan Biziel University Hospital No 2 in Bydgoszcz
Cerebral Palsy, Dystonia
Whole Body Vibration for Dystonia Cerebral Palsy
Health bones allow us to move and walk freely without pain. Physical activities have been shown to relate to healthy bone growth.
- Trial name
- WBVT (NCT03779308)
- Testing
- whole body vibration therapy
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- The Hong Kong Polytechnic University
Myoclonus-Dystonia, DYT11
EMOTION & COGNITION IN MYOCLONUS DYSTONIA (AGENT10-ECODYST)
Background: Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype.
- Trial name
- NCT05671068
- Where
- France
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cervical Dystonia
Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex
This study will compare Xeomin®, a botulinum toxin medication, in shorter treatment intervals (Short Flex dosing) to the standard interval dosing (Long Flex dosing) to determine if the response to treatment is comparable in both…
- Trial name
- NCT01486264
- Testing
- Xeomin®
- Where
- 43 sites in United States
- Volunteers
- 283 people
- Sponsor
- Merz Pharmaceuticals GmbH
Cervical Dystonia
Clinical Study of Ingrezza (Valbenazine) for the Treatment of Cervical Dystonia
Study of Ingrezza (Valbenazine) for the treatment of cervical dystonia.
- Trial name
- NCT05157100
- Testing
- Ingrezza Pill
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Orthopedic Foundation
DYT-1, DYT1
Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
This is a research study using transcranial magnetic stimulation (TMS) to investigate interactions between the sensory system and the motor cortex in primary generalized dystonia (DYT1 dystonia) subjects who undergo deep brain…
- Conditions
- DYT-1, DYT1, DYT 1, Dystonia
- Trial name
- NCT01435681
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Florida
Torticollis
Comparative Trial of Botox in the Management of Children With Congenital Muscular Torticollis
The primary purpose is to investigate the effect of Botox on the treatment of congenital muscular torticollis (CMT). The investigators' hypothesis is that a Botox injection will be an effective treatment when used in conjunction…
- Trial name
- NCT00175604
- Testing
- Botox
- Where
- Canada
- Sponsor
- University of British Columbia
Cervical Dystonia
Three-dimensional Analysis of Obliquus Capitis Inferior Muscle Function in the Rotatory Form of Cervical Dystonia
Cervical dystonia is the most common form of focal dystonia in adults (50-82%). It manifests itself by a abnormal attitude of the head, intermittent or permanent, due to involuntary contraction of the cervical muscles which…
- Trial name
- STOCI (NCT05327985)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson's Disease, Essential Tremor
Local Fields Potentials Recorded From Deep Brain Stimulating Electrodes
Deep Brain Stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's Disease (PD), Essential Tremor (ET) and Dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- LFP DBS (NCT02071446)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease, Dystonia
Physiological Brain Atlas Development
Enrollment of candidates undergoing a deep brain stimulator (DBS) implant.
- Conditions
- Parkinson Disease, Dystonia, Tremors, Obsessive Compulsive Disorder
- Trial name
- NCT01210534
- Testing
- No intervention
- Where
- United States
- Volunteers
- 456 people
- Sponsor
- Ohio State University
Essential Tremor, Dystonia
Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement Disorders
The aim of this study is to asses the efficacy and the clinical safety of the transcranial magnetic resonance guided high intensity focused ultrasound system ExAblate 4000, InSightec Ltd.
- Conditions
- Essential Tremor, Dystonia, Parkinson's Disease
- Trial name
- NCT01698450
- Testing
- Non-invasive intervention with focused ultrasound (ExAblate 4000)
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Children's Hospital, Zurich
Cervical Dystonia
Clinical and Kinematic Assessment for Determination of Botox® Injection Parameters in Cervical Dystonia
This study investigates the use of a kinematic measurement device to quantify the abnormal head movements and postures in patients with cervical dystonia (CD) in order to individualize and optimize botulinum toxin type A (BoNT-A)…
- Trial name
- NCT02662530
- Testing
- Botulinum Toxin Type A
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Western University, Canada