Clinical trials: E-Cig Use
Electronic Cigarettes
Effects of e-Cigarettes on Nicotine Withdrawal
This behavioral pharmacology laboratory experiment will assess whether sweet (vs. non-sweet) flavored e-cigarette solutions reduce tobacco withdrawal symptoms and motivation to smoke among 40 smokers interested in trying…
- Trial name
- NCT03098004
- Testing
- e-Cigarette
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Electronic Cigarette Use
Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers
This study is being conducted to evaluate nicotine uptake, the potential abuse liability, and puffing topography associated with the use of an electronic nicotine delivery system (ENDS) with tobacco- and menthol-flavored…
- Trial name
- NCT04620616
- Testing
- RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Subject Usual Brand ENDS
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cheerain HK Limited
Perception of Vaping
Perception of Health Promotion Messages
The specific aims of this study are: 1. To compare the perceived message effectiveness (PME) of AI-generated vaping prevention materials with existing traditionally generated (typically by a health authority) prevention materials…
- Trial name
- NCT07042789
- Testing
- Material source: AI generated ads vs existing ads by health agency, source labelling conditions: control condition, AI condition, health agency condition, combined condition
- Where
- Australia
- Volunteers
- 763 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Nicotine Vaping
Kick-Nic! Youth Quit Vaping App
High school and middle school students who want to quit vaping will be randomized to receive the Kick-Nic! app or a control NCI website to determine the efficacy of the app for vaping cessation.
- Trial name
- NCT06662305
- Testing
- Kick-Nic! mobile phone application, NCI Quit Vaping website
- Where
- United States
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Yale University
Vaping
Responses to E-cigarette Message Source and Presentation
The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who…
- Trial name
- NCT06274723
- Testing
- Expert, one-sided, Expert, two-sided, Peer, one-sided
- Where
- United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Smoking Cessation, Vaping
Concentration Impact Nicotine Salt
Double-blind (for the two active arms), randomized, three-arm (two active and one control) clinical trial investigating factors (e.g.
- Trial name
- CINS (NCT04725656)
- Testing
- Smoking cessation counseling, Open system vape device and nicotine salt e-liquids
- Where
- Switzerland
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
E-cigarette Use
Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use
The investigators aim to (1) establish a methodology for the evaluation of the biodistribution of radio-labeled nicotine following e-cigarette use, (2) determine the oral/pulmonary distribution of nicotine following e-cigarette…
- Trial name
- NCT03491059
- Testing
- C-11 labeled nicotine, PET/CT imaging
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Healthy Volunteers
A Study to Evaluate Nicotine Uptake and Biomarkers in Smokers Using mybluTM Electronic Cigarettes
This study evaluates the overall performance of the currently-marketed MybluTM e-cigarette device and pods, as assessed by nicotine uptake, exposure to smoke constituents, safety and consumer satisfaction, over 8 days.
- Trial name
- NCT04430634
- Testing
- Myblu variant A, Myblu variant B, Myblu variant C
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fontem US LLC
Nicotine Dependence
Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2
This study is to examine if inhaled doses of an e-cigarette flavor, alone and in combination with menthol, changes the appeal of e-cigarettes containing low and high doses of nicotine.
- Trial name
- NCT03168191
- Testing
- Nicotine, Experimental Flavor, Menthol Flavor
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Yale University
Arterial Inflammation
Arterial Inflammation and E-Cigarettes
Arterial inflammation will be compared using PET scanning in 3 groups: 1) Non-smokers, 2) Tobacco cigarette smokers, 3) Electronic cigarette users.
- Trial name
- NCT02734888
- Testing
- No drug or device, only a test. The test is called a PET/CT
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Nicotine Replacement Therapy
A Study of Blood Levels of Nicotine Following an Electronic Cigarette
The purpose of this study is to assess the amount of nicotine that is absorbed into the blood stream following the use of a new Electronic Cigarette device called the CN electronic cigarette.
- Trial name
- NCT02794220
- Testing
- CN electronic cigarette 10 mg, CN electronic cigarette 15 mg, Nicorette Inhalator 15 mg
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Simbec Research
Airway Morbidity, Smoking Cessation
Adverse Airway Effects From Tobacco and E-Cigarettes
The purpose of the study conducted at VA Medical Center in Miami is to determine if smoking electronic cigarettes (known as e-cigarettes) that contain nicotine have less negative effects than regular cigarettes on the person's…
- Conditions
- Airway Morbidity, Smoking Cessation, Nicotine Adverse Reaction, Smoking, Tobacco
- Trial name
- NCT03251053
- Testing
- Electronic cigarette use, Control regular cigarette smokers
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Miami VA Healthcare System
Energy Intake, Food Intake
The Acute Effect of Vaping on Food Intake
This study assesses the acute effects of a standardized 20-minute vaping episode compared to a non-vaping control condition on ad libitum food intake during a 30-minute buffet meal, occurring approximately 45 minutes after the…
- Conditions
- Energy Intake, Food Intake, E-Cig Use, Appetite
- Trial name
- NCT04219189
- Testing
- Vaping condition, Control condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cigarette Smoking-Related Carcinoma
Impact of E-cigarette Use on the Body
This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects.
- Trial name
- NCT04972513
- Testing
- Biospecimen Collection, Nitric Oxide Breath Test, Oscillometry
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Vaping Behavior
High Impact E-cigarette Advertisement Features
This randomized controlled trial aims to examine the effects of high-impact e-cigarette advertisement features among young adults of various tobacco-use statuses.
- Trial name
- NCT06704295
- Testing
- Control ad with dark gray product with tobacco flavor name, Dark gray product with strawberry flavor name, Colorful (strawberry color) product with strawberry flavor name
- Where
- United States
- Volunteers
- 3,083 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Vaping
Evaluating Narrative Vaping Prevention Video Ads for Adolescents and Young Adults
The purpose of this study is to evaluate the persuasive effectiveness of narrative advertisements: with acted-out plots (where characters enact a vaping-related experience) versus narrative advertisements without acted-out plots…
- Trial name
- NCT07767929
- Testing
- Acted-Out Narrative Ads, Non-Acted-Out Narrative Testimonial Ads, Neutral Control Videos
- Where
- 2 sites in United States
- Volunteers
- 1,910 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cannabis Use, Tobacco
Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis
This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.
- Conditions
- Cannabis Use, Tobacco, Biomarkers
- Trial name
- NCT07694466
- Testing
- Cannabis (THC), Tobacco Cigarette
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hannah Harris
Second Hand Tobacco Smoke
Study to Evaluate Constituents in Exhaled Breath and Room Air From Use of E-vapor Products and Conventional Cigarettes
An open-label, single center, three-arm observational study to examine emissions from e-cigarettes versus conventional cigarettes under three environmental settings of typical residential, office and hospitality facilities.
- Trial name
- NCT03605641
- Testing
- JUUL, VUSE Solo, Conventional Cigarette
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.