Clinical trials: E-cigarette Use
Tobacco Smoking, Vaping
Vaping Cessation Using the Ottawa Model for Smoking Cessation Among E-Cigarette Users
This study aims to determine if a standardized approach including counselling and Nicotine Replacement Therapy (NRT) can help e-cigarette users quit vaping.
- Trial name
- VC-OMSC (NCT06164678)
- Testing
- OMSC
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Electronic Cigarette Use
Effects of E-cigarette Use on Health
Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however their long-term health effects are unknown.
- Trial name
- VAPECHECK (NCT06610838)
- Testing
- Health Assessments
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Smoking, Smoking Behaviors
CSD190203: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting
This study will be a single-center, randomized, controlled, open-label, parallel 2-cohort study to evaluate the puffing patterns of individuals switching from a similar usual brand (UB) Electronic Nicotine Delivery System (ENDS)…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04104152
- Testing
- CSD1902-11, CSD1902-12, CSD1902-13
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Nicotine Dependence
Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal
The proposed research is a longitudinal human lab study to examine how measures of abuse liability and product appeal vary by e-cigarette device type, and how these lab assessments may predict subsequent e-cigarette and other…
- Trial name
- NCT02520349
- Testing
- MarkTen and e-Go e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Truth Initiative
Tobacco Use
Robot-Assisted Immersive Escape Room Game for Tobacco Harm Prevention Among Elementary School Students
This study evaluates the effectiveness of a robot-assisted immersive escape room intervention for tobacco harm prevention among upper-grade elementary school students.
- Trial name
- NCT07501572
- Testing
- Robot-assisted Immersive Escape Room Game, Traditional Tobacco Harm Prevention Education
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Vaping, Smoking Cessation
Vaping Prevention and Vaping in Youth (Vapechat)
Many youth are addicted to nicotine due to increased nicotine vaping (e.g., e-cigarettes). Unfortunately, there are no effective interventions to help teens quit vaping.
- Trial name
- Vapechat (NCT06003439)
- Testing
- Virtual Reality Program, VR Program
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Boston University
Healthy Smokers, Smoking Cessation
Efficacy and Safety of an Electronic Nicotine Delivery Device (E-Cigarette)
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (E-Cigarette) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01164072
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Catania
Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Vaping and Smoking Withdrawal Project
The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic…
- Trial name
- VASP (NCT05772845)
- Testing
- Acute (24-hour) abstinence, Ad libitum smoking/vaping
- Where
- United States
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Smoking
Monitoring the Transition From Smoking to E-cigarettes
Electronic cigarettes (e-cigarettes) have proved very popular and a meteoric rise in their usage is currently under way. People purchase them as an aid to giving up smoking, to reduce cigarette consumption, to minimise withdrawal…
- Trial name
- NCT02752022
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Smoking
Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum
The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three menthol electronic cigarettes…
- Trial name
- NCT02664012
- Testing
- Own Brand Menthol Cigarette, Electronic Menthol Cigarette #1, Electronic Menthol Cigarette #2
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Tobacco Use
Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)
This study is proposing a four condition Electronic Tobacco Marketplace (ETM) study to determine if banning normal nicotine content (NNC) is sufficient for encouraging smokers to switch to potentially less harmful products or if…
- Trial name
- NCT05320887
- Testing
- Normal Nicotine Content Vape with all flavor e-liquids, Normal nicotine content vape with tobacco e-liquids, Low nicotine content vape with all flavor e-liquids
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cigarette Smoking, Addiction
Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder
Patients in addiction treatment have exceptionally higher rate of cigarette smoking and very low quit rates compared to the general population.
- Conditions
- Cigarette Smoking, Addiction, E Cig Use
- Trial name
- NCT04063267
- Testing
- E cigarettes, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Electronic Cigarettes
Effects of e-Cigarettes on Nicotine Withdrawal
This behavioral pharmacology laboratory experiment will assess whether sweet (vs. non-sweet) flavored e-cigarette solutions reduce tobacco withdrawal symptoms and motivation to smoke among 40 smokers interested in trying…
- Trial name
- NCT03098004
- Testing
- e-Cigarette
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Vaping
Feasibility of Treatment for Vaping Cessation
Researchers are gathering information on the feasibility of treating e-cigarette users with 12-weeks of varenicline (Chantix®) in assisting with stopping the use of e-cigarettes.
- Trial name
- VAPEscape (NCT04317300)
- Testing
- Varenicline, brief behavioral therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Cessation, Addiction
An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention
The Healthy Futures: Alternative-to-Suspension Curriculum is a free, online curriculum developed to educate students and provide them with resources to quit tobacco/nicotine use.
- Trial name
- NCT06483412
- Testing
- Healthy Futures: Alternative-to-Suspension Curriculum
- Where
- United States
- Volunteers
- 2,540 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alcohol Abuse, Nicotine Dependence Tobacco Product
Reactions to E-cigs and Alcohol
The purpose of this study is to 1) examine cognitive acuity following e-cig use (as compared to no e-cig use), 2) examine motor coordination following beer and e-cig use (as compared to beer consumption only).
- Trial name
- NCT03449017
- Testing
- E-cig use
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nicotine, Nicotine Vaping
Developing E-liquid Product Standards (Sweet Spot Study)
The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of…
- Conditions
- Nicotine, Nicotine Vaping, E-cigarette Use
- Trial name
- NCT05864586
- Testing
- Vaping study EC A, Vaping study EC B, Vaping study EC C
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Vaping, Smoking
Adolescent Inpatient Tobacco and ENDS Intervention
The purpose of this study is to develop and evaluate an evidence-based intervention to assist adolescents and young adults with current vaping to quit vaping and smoking.
- Trial name
- NCT05936099
- Testing
- E-cigarette & Tobacco Use Treatment Intervention
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Tobacco Use Disorder, Smoking
Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
The purpose of this study is to examine the feasibility of using e-cigarettes as a method for harm reduction and the effects of providing e-cigarettes (or placebo e-cigarettes) on smoking outcomes.
- Trial name
- NCT02628964
- Testing
- e-cigarettes
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Nicotine Dependence, Nicotine Vaping
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic.
- Trial name
- NCT05962229
- Testing
- (S)-Nicotine, (R)- nicotine, Racemic nicotine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco