Clinical trials: EDS
Language Discordance
Cost Effectiveness of Language Services in Hospital Emergency Departments (EDs)
Numerous studies suggest that the use of in-person, professionally trained medical interpreters can reduce health care costs associated with diagnosing and treating patients with limited English proficiency.
- Trial name
- NCT01041014
- Testing
- Professional medical interpreter
- Where
- 2 sites in United States
- Volunteers
- 447 people
- Sponsor
- Mathematica Policy Research, Inc.
Complex Aortic Aneurysms, Thoracoabdominal Aneurysms
Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices
The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with…
- Conditions
- Complex Aortic Aneurysms, Thoracoabdominal Aneurysms, Pararenal Aneurysms, Juxtarenal Aneurysms
- Trial name
- CARPE-CMD (NCT02050113)
- Testing
- Custom Made Fenestrated or Branched Stent Graft
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Andres Schanzer
Ehlers-Danlos Syndrome, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Ehlers-Danlos Syndrome
Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility.
- Trial name
- OSA in EDS (NCT02435745)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Ehlers-Danlos Syndrome
Registry of Ehlers-Danlos Syndrome
RED is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains…
- Trial name
- RED (NCT04133272)
- Where
- Italy
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Dynamic Stability Exercises in Patients With Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
Background: Symptomatic hypermobility may lead to a number of restrictions in daily life. So far, there is a lack of effective treatments.
- Trial name
- NCT05800262
- Testing
- Dynamic stability exercises
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- University Hospital, Linkoeping
Hypermobile Ehlers-Danlos Syndrome, Hypermobility Syndrome
Patient-based Care Versus Standard Care for Patients With hEDS/HSD and Multidirectional Shoulder Instability
For hEDS or HSD patients with MDI, a multidisciplinary treatment approach is suggested. As follows, physiotherapy plays a key role in this integrative management.
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Hypermobility Syndrome, Multidirectional Subluxation of Shoulder
- Trial name
- NCT04666896
- Testing
- Tailored home-based exercise therapy, Standard home-based exercise therapy
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Ghent
Antibiotic Resistance, Bacterial
Antibiotic Resistance in Danish EDs.
The spread of multiresistant bacteria is an increasing problem which will mean increased costs, morbidity and mortality in the coming years.
- Trial name
- AB-RED (NCT03352167)
- Where
- 8 sites in Denmark
- Volunteers
- 5,117 people
- Sponsor
- University of Southern Denmark
Suicide Risk
Telehealth to Improve Prevention of Suicide (TIPS)
The study will rigorously evaluate whether synchronous, within-visit telemental health evaluation and intervention services can successfully overcome poor access to behavioral health and substandard suicide-related care in…
- Trial name
- TIPS (NCT04800029)
- Testing
- TIPS Program, TIPS Program + ED-SAFE
- Where
- United States
- Volunteers
- 32,406 people
- Sponsor
- University of Massachusetts, Worcester
Ehlers-Danlos Syndrome, Irritable Bowel Syndrome
RCT of Gut-directed Hypnotherapy in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders
This randomized, controlled trial (RCT) will evaluate the effectiveness of gut-directed hypnotherapy for management of Irritable Bowel Syndrome (IBS) in individuals diagnosed with Ehlers-Danlos Syndromes or Generalized…
- Conditions
- Ehlers-Danlos Syndrome, Irritable Bowel Syndrome, Hypermobility Syndrome, Gastrointestinal Dysfunction
- Trial name
- NCT06325345
- Testing
- Gut-directed hypnotherapy, Standard Medical Therapy
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University Health Network, Toronto
Ehlers-Danlos Syndromes (EDS)
Evaluation of the Role of Serum Tenascin-X Levels in the Diagnosis of Hypermobile Ehlers-Danlos Syndrome
Thirteen types of EDS have been described based on their clinical manifestations and genetic backgrounds. Their diagnosis relies on personal and family medical history, together with established clinical criteria.
- Trial name
- DIAGNOSEDh (NCT07899554)
- Testing
- Blood sampling
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Excessive Daytime Sleepiness, Obstructive Sleep Apnea
Pitolisant (BF2.649) in the Treatment of EDS in Patients With OSA
The first objective of this study is to demonstrate the efficacy and safety of pitolisant given at 10, 20, or 40 mg per day versus placebo during 12 weeks of the Double Blind period, to treat the Excessive Daytime Sleepiness…
- Trial name
- HAROSA3 (NCT02739568)
- Testing
- Pitolisant (BF2.649)
- Where
- 6 sites in Bulgaria, North Macedonia
- Volunteers
- 389 people
- Sponsor
- Bioprojet
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data.
- Conditions
- Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated, Cardiomyopathy Restrictive, Arrhythmogenic Right Ventricular Dysplasia
- Trial name
- RENOMICA-Hcor (NCT06546137)
- Testing
- whole genome sequencing
- Where
- 27 sites in Brazil
- Volunteers
- 1,211 people
- Sponsor
- Hospital do Coracao
Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder
Hypermobile Ehlers-Danlos Syndrome - Transcutaneous Auricular Neuromodulation
Investigate whether at-home transcutaneous auricular VNS (tAN: transcutaneous auricular neurostimulation) improves a battery of nine key physical and psychological symptoms of a group of hEDS (Hypermobile Ehlers-Danlos Syndrome…
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Ehlers-Danlos Syndrome
- Trial name
- hEDS-tAN (NCT06105541)
- Testing
- Transcutaneous Auricular Neurostimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
Vascular Ehlers-Danlos Syndrome
Heart Coherence Training on Vascular Ehlers-Danlos Syndrome Patients
Vascular Ehlers-Danlos Syndrome (VEDS) is caused by pathogenic variants of the COL3A1 gene, resulting abnormal Type III collagen protein.
- Trial name
- NCT05994664
- Testing
- Heartmath Intervention, Control Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Ehlers-Danlos Syndrome, Hypermobile EDS (hEDS)
Integrative Medicine for Hypermobility Spectrum Disorder and Ehlers-Danlos Syndromes (IMforHSDandEDS)
A feasibility study of an integrative medicine program among patients with Hypermobility Spectrum Disorder (HSD) or Ehlers-Danlos syndromes (EDS)
- Conditions
- Ehlers-Danlos Syndrome, Hypermobile EDS (hEDS), Hypermobility Syndrome, EDS
- Trial name
- NCT04734041
- Testing
- Anti-inflammatory (Mediterranean-style) diet, Behavioral and psychosocial support
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Marfan Syndrome, Turner Syndrome
National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of…
- Conditions
- Marfan Syndrome, Turner Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome
- Trial name
- GenTAC (NCT01322165)
- Where
- 7 sites in United States
- Volunteers
- 3,706 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ehlers-Danlos Syndrome Hypermobility Type
Wearing a Compression Garment for Patients With Hypermobility Type of Ehlers-Danlos Syndrome
The Ehlers-Danlos syndrome (EDS) is a rare genetic disease caused by an anomaly of the connective tissue. This syndrome has different forms. Hypermobility type is the most common.
- Trial name
- VETCOSED (NCT02144532)
- Testing
- short-sleeved vest CICATREX SED®)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Hospices Civils de Lyon
Joint Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Central Sensitization and Physical Activity in Adolescents With HSD/hEDS
Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear.
- Trial name
- NCT05633225
- Testing
- Submax exercise test on a bicycle ergometer
- Where
- 2 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Ehlers-Danlos Syndrome Hypermobility Type (hEDS)
3D Printed Orthosis for Wrist Instability for Ehlers-Danlos Syndrome Patient
This study will determine if using 3D scanning and 3D printing technology to create an orthosis to improve the quality of life for people with Ehlers Danlos Syndrome (EDS) compared to existing prefabricated orthoses.
- Trial name
- NCT07565636
- Testing
- 3D scanned and 3D printed wrist hand orthosis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- ELewis
Connective Tissue Disease, Dissecting Aneurysm
Study of Heritable Connective Tissue Disorders
The purposes of this study are to identify the genes responsible for inherited connective tissue disorders and learn about the range of medical problems they cause.
- Conditions
- Connective Tissue Disease, Dissecting Aneurysm, Ehlers Danlos Syndrome, Marfan Syndrome
- Trial name
- NCT00001641
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)