Clinical trials: EUS
Pancreatic Cancer, Pancreatic Adenocarcinoma
Pancreatic Cancer Models Developed From EUS Guided Biopsy Tissue
Pancreatic cancer is a very aggressive cancer. Over the past 40 years there has not been much progress made in reducing deaths from this cancer.
- Conditions
- Pancreatic Cancer, Pancreatic Adenocarcinoma, Pancreatic Cyst
- Trial name
- NCT03140592
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Stony Brook University
Pancreatic Ductal Adenocarcinoma
Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma
The purpose of this study is to perform a pilot phase II trial to evaluate the safety and efficacy of combined EUS-RFA, chemotherapy, and systemic immunotherapy (pembrolizumab) for the treatment of locally advanced unresectable…
- Trial name
- PANCARDINAL-2 (NCT06831136)
- Testing
- Neoadjuvant Chemotherapy (NAC), Immunotherapy (pembrolizumab), Endoscopic ultrasound (EUS)-guided radiofrequency ablation (RFA)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center, Houston
Rectal Neoplasms
Effective Study of Preoperative Short-course Radiotherapy for the Advanced Resectable Rectal Cancer
The local recurrence of rectal cancer is one of the main problem that fail the treatment. The preoperative neoadjuvant (chemo)radiotherapy has been confirmed to reduce the local recurrence rate,especially in the advanced rectal…
- Trial name
- NCT01437514
- Testing
- preoperative short-course radiotherapy
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- West China Hospital
Abdominal Neoplasms
EUS GUIDED Transduodenal Biopsy Using the 19G Flex
This study evaluates the feasibility, safety and accuracy of a 19 gauge (19G) needle in nitinol in the performance of endoscopic ultrasound (EUS) guided transduodenal biopsy for the acquisition of samples for histologic analysis.
- Trial name
- NIFLEX (NCT02307253)
- Testing
- Expect™19Flex needle (Boston Scientific Corp.,Natick,MA,USA)
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 246 people
- Sponsor
- Catholic University of the Sacred Heart
Liver Cirrhoses, Portal Hypertension
EGD vs EUS in Diagnosing Portal Hypertension in Cirrhotic Patients.
Liver cirrhosis with the further development of portal hypertension implies structural and vasculature alteration in the portosplenic circulation.
- Trial name
- NCT04191369
- Testing
- Esophagogastroduodenoscopy, Endoscopic ultrasound
- Where
- Ecuador
- Volunteers
- 35 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Gastric Varices
Angiography for Evaluation of the Feeder Vessel in EUS-guided Coils and Cyanoacrylate Therapy for Gastric Varices
INTRODUCTION: Bleeding from gastric varices (GV) is associated with a high mortality rate. Injection of cyanoacrylate (CYA) using standard gastroscope has demonstrated to achieve higher hemostasis and lower rebleeding rates…
- Trial name
- NCT03277937
- Testing
- angiography in EUS-injection of coils + CYA
- Where
- Ecuador
- Volunteers
- 30 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Distal Malignant Biliary Obstruction
Fesibility of EUS-guided Gallbladder Drainage With a New-type of Electrocautery LAMS in the Treatment of Malignant Distal Biliary Obstruction
Distal malignant biliary obstruction results from different types of tumors including pancreatic cancer, biliary tract cancer (BTC), gallbladder cancer, and metastasis, which can lead to obstructive jaundice.
- Trial name
- DC LAMS (NCT05271994)
- Testing
- endoscopic biliary drainage
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas Mater Domini
Cancer, Infection
Comparison of "Wet Suction" Technique to Contemporary "Dry Suction" Technique Using a 22 Gauge Needle for EUS FNA
ROLE OF SUCTION IN EUS-FNA: Current suction technique involves suctioning the aspirate into the needle that has an air column. The needle is not flushed with any liquid prior to passing into the desired solid lesion.
- Conditions
- Cancer, Infection, Inflammation, Tumor
- Trial name
- NCT01720745
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- University of Minnesota
Rectal Cancer
Endoscopic Ultrasound Predict the Sensitivity of Stage II / III Rectal Cancer Preoperative Concurrent Chemoradiotherapy
The purpose of this study is to determine the role of endoscopic ultrasound measurement of the primary tumor maximum diameter changes in absolute / relative values in predicting the tumor regression after concurrent…
- Trial name
- NCT01582750
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese Academy of Medical Sciences
Solid Pancreatic Mass Lesions
EUS-FNA With and Without Suction
To compare the number of passes required for cellblock acquisition with and without suction using the 25g needle.
- Trial name
- NCT02072915
- Testing
- Suction
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Alabama at Birmingham
Mediastinal ( Chest) Masses, Gastrointestinal Subepithelial Tumors
Role of Endoscopic Ultrasound Elastography in Diagnosis of Gastrointestinal Subepithelial and Mediastinal Lesions
The aim of this study is to evaluate the role of endoscopic ultrasound (EUS) in the diagnosis of mediastinal and gastrointestinal subepithelial lesions.
- Trial name
- NCT07419191
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Assiut University
GI Cancer
Macroscopic on Cite Evaluation of EUS-FNA Specimen With 22 G Needle
In order for the diagnosis of digestive system tumors and their appropriate treatment afterward, the type of these tumors should be determined by the pathologist.
- Trial name
- NCT04774679
- Testing
- Endosonographic fine needle aspiration biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kocaeli University
Gastric Outlet Obstruction
EUS-guided Versus Laparoscopic Gastrojejunostomy for Malignant Gastric Outlet Obstruction
Gastric outlet obstruction (GOO) is a common complication of various types of malignancy arising from the pancreas, bile ducts, retroperitoneum and distal stomach.
- Trial name
- EATING (NCT05605327)
- Testing
- EUS-guided gastroenterostomy, Laparoscopic gastroenterostomy
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neuroendocrine Tumors, Autoimmune Pancreatitis
A Real-world Comparison of FNB and FNA in IHC-required Lesions.
Endoscopic ultrasound (EUS)-guided fine needles with side fenestrations are used to collect aspirates for cytology analysis and biopsy samples for histologic analysis.
- Conditions
- Neuroendocrine Tumors, Autoimmune Pancreatitis, Gastrointestinal Stromal Tumors
- Trial name
- NCT05565066
- Testing
- FNB group, FNA group
- Where
- China
- Volunteers
- 439 people
- Sponsor
- Huazhong University of Science and Technology
Solid Neoplasms
Endoscopic Ultrasonography (EUS) Guided Fine Needle Aspiration Using Free Stylet 22g and 25 g Needles
This is a randomized controlled study comparing EUS-FNA with 22 gauge and 25 gauge needles in consecutive patients. Summary Background: three needle sizes for endoscopic ultrasonography guided fine needle aspiration (EUS-FNA) are…
- Trial name
- NCT01543282
- Testing
- Endosonography guided fine needle aspiration cytology ( Cook Medical, Boston Scientific)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Portal Hypertension, Chronic Liver Disease
Within-Session Repeatability of EUS-Guided Portal Pressure Gradient Measurement
This prospective multicentre observational reliability study will determine how much a repeated endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement differs from the first measurement in the same patient…
- Conditions
- Portal Hypertension, Chronic Liver Disease, Liver Cirrhosis
- Trial name
- REPEAT-PPG (NCT07877298)
- Testing
- Repeated EUS-Guided Portal Pressure Gradient Measurement
- Where
- 5 sites in Belgium, Canada and 2 more
- Volunteers
- 150 people
- Sponsor
- University Hospital Muenster
Pancreas Neoplasms, Lymphatic Metastasis
Prospective Multi-center, Single Blinded, Randomized, Controlled Trial of EUS-FNB and EUS-FNA on Solid Occupying Lesion
The purpose of this study is to compare the diagnosis accuracy of FNA and FNB biopsy on pancreatic, retroperitoneal, mediastinum and pelvic cavity solid occupying lesions.
- Conditions
- Pancreas Neoplasms, Lymphatic Metastasis, Neoplasm Metastases, Unknown Primary Neoplasm Metastasis
- Trial name
- NCT02327065
- Testing
- EUS-FNA (EchoTip Ultra), EUS-FNB (EchoTip ProCore)
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Huazhong University of Science and Technology
Pancreatic Cancer
Intraoperative Endoscopic Ultrasound for Pancreatic Cancer
Nowadays pancreatic cancer is one of the deadliest oncological pathologies. The only effective curative tool is the surgery. Before the intervention, an endoscopic ultrasound is performed on the patient to carry out the biopsy of…
- Trial name
- EchoSurg (NCT04899739)
- Testing
- Echoendoscopy
- Where
- France
- Volunteers
- 33 people
- Sponsor
- IHU Strasbourg
Pancreatic Diseases
Fine-needle Biopsy Combined With Macroscopic On-site Evaluation for Diagnosis of Solid Pancreatic Lesions
The goal of this clinical trial is to compare the diagnostic efficacy, core tissue acquisition ability, number of punctures and puncture time of macroscopic on-site evaluation (MOSE) and two punctures alone in Endoscopic…
- Trial name
- NCT06994611
- Testing
- MOSE application, Conventional processing
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Changhai Hospital
Diabetes Mellitus
Impact of Self-care Education Program in Patients With Type 2 Diabetes in Primary Care in the Basque Country
Main objective:To evaluate the effectiveness of the "Diabetes Self-Management Programme" (DSMP) on the metabolic control, cardiovascular risk reduction, quality of life and self-efficacy in adult patients with type 2 diabetes…
- Trial name
- NCT01642394
- Testing
- Diabetes Self-Management Program
- Where
- Spain
- Volunteers
- 594 people
- Sponsor
- Osakidetza