Clinical trials: Early Cancer Detection
Normal Volunteers, Hepatitis
Protein Biomarker in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fifth commonest cancer in the world with poor prognosis, as the annual mortality is almost equivalent to the incidence. This is mainly due to late diagnosis and co-morbid liver dysfunction.
- Conditions
- Normal Volunteers, Hepatitis, Liver Cirrhosis, Hepatocellular Carcinoma
- Trial name
- NCT00465842
- Where
- Singapore
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Colorectal Cancer, Grastic Cancer
Feasibility of Multi-cancer Early Detection Test in Screening Population (NQMD-CS)
This is a prospective, multicenter screening cohort study designed to evaluate the feasibility of a blood-based multi-cancer early detection (MCED) test in an asymptomatic screening population.
- Conditions
- Colorectal Cancer, Grastic Cancer, Esophageal Cancer, Lung Cancer
- Trial name
- NCT07834268
- Testing
- MCED
- Where
- 2 sites in China
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital of Guangzhou Medical University
Breast Cancer
Effect of Lifestyle Factors and Hormone Function on Breast Density in Healthy Hispanic Women Who Are Undergoing Mammography for Breast Cancer Screening
RATIONALE: Lifestyle factors, such as physical activity, diet, and obesity, and hormone function may affect breast density. Screening tests, such as mammography, may help doctors find tumor cells early and plan better treatment…
- Trial name
- NCT00131950
- Testing
- physiologic testing, study of socioeconomic and demographic variables, breast imaging study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Social Support, Screen Time
The Green Prescription Program for Increasing Physical Activity in Adolescents
This study evaluated the effectiveness of the Green Prescription, a school-based behavioral intervention that incorporated health education, designed to increase physical activity among adolescents aged 15-17 years who were…
- Conditions
- Social Support, Screen Time, Physical Inactivity, Sedentary Lifestyle
- Trial name
- NCT07770997
- Testing
- Green Prescription (Teacher-Led), Green Prescription (Interdisciplinary)
- Where
- Poland
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Colorectal Cancer
RCT of Automated Telephone Outreach to Improve Colorectal Cancer Screening
This large randomized controlled trial is testing the effectiveness of automated telephone outreach with speech recognition to improve rates of screening for colorectal cancer.
- Trial name
- NCT00792285
- Testing
- Automated Telephone Outreach with Speech Recognition
- Where
- United States
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- Harvard Pilgrim Health Care
Lung Cancer
Early Cancer Detection Test - Lung Cancer Scotland
HYPOTHESIS In a high risk population the EarlyCDT-Lung test reduces the incidence of late stage tumours;3 / 4 / Unclassified (U) at diagnosis compared to normal clinical practice.
- Trial name
- ECLS (NCT01925625)
- Testing
- Early CDT Lung blood test
- Where
- 3 sites in United Kingdom
- Volunteers
- 12,210 people, healthy volunteers welcome
- Sponsor
- Stuart Schembri
Stomach Cancer
Development of Free DNA Multi-target Methylated PCR for Auxiliary Diagnosis of Gastric Cancer
This was a case control, non-intervention study jointly developed by Fudan University Cancer Hospital and Shanghai Singlera Genomics Company.
- Trial name
- NCT05336058
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Sedentary Lifestyle
The Effects of Smartphone Use on Physical Activity, Sedentary Behaviour, Sleep, and Well-being
Previous studies suggest that screen use (phones, TV, computers, etc) may negatively impact both sleep and mental health (1-3). The purpose of this study is to determine the impact of reducing smartphone use on sleep, physical…
- Trial name
- NCT03752385
- Testing
- reducing smartphone screen time
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Breast Cancer Screening
Adapting a Mammography Decision Aid to Support Women Living in a Community Contaminated by PFAS
This community-engaged research project will test an adapted online breast cancer screening decision aid to address the needs of women living in an area where environmental contamination has increased concern about breast cancer…
- Trial name
- NCT06098118
- Testing
- MyMammogram decision aid
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Cervical Cancer Screening
Comparison of the Hologic Genius Digital Diagnostics System With the ThinPrep Imaging System
Quality assurance of the laboratory examinations. Retrospective non-interventional study with ThinPrep slides collected as part of the German Co-Screening Program for routine diagnostic.
- Trial name
- NCT05000125
- Testing
- Hologic's Genius Digital Diagnostics System
- Where
- Germany
- Volunteers
- 1,994 people, healthy volunteers welcome
- Sponsor
- Hologic Deutschland GmbH
Spinal Muscular Atrophy, Neonatal Hyperbilirubinemia
Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform.
In this, here we want to present a new method for analysis variation in gene copy number for patients and carriers of SMA. This is a relative quantitation method and, therefore, relies on the inclusion of one or more internal…
- Conditions
- Spinal Muscular Atrophy, Neonatal Hyperbilirubinemia, Colon Cancer
- Trial name
- NCT00154960
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Breast Cancer Screening, Artificial Intelligence (AI)
Screening Mammography: Single Reading by One Radiologist With AI vs. Double Reading by Two Radiologists (AI-BCSQ)
A randomized prospective study comparing the evaluation of mammography images in a breast cancer screening programme by a single radiologist with AI support versus standard double reading by two radiologists without AI support.
- Conditions
- Breast Cancer Screening, Artificial Intelligence (AI), Breast Cancer Screening and Diagnosis
- Trial name
- AI-BCSQ (NCT07075679)
- Testing
- Group with AI iCAD version 3, Group without AI
- Where
- Czechia
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Olomouc
Healthy, Cervical Cancer Screening
Cross-Cultural Adaptation and Psychometric Validation of the Cervical Cancer Screening Uptake Questionnaire (CCSTQ) in Turkish Women
Cervical cancer remains an important public health issue affecting women's health. Cervical cancer screening plays a key role in reducing morbidity and mortality through early detection.
- Trial name
- NCT07451340
- Testing
- Validity and reliability study
- Where
- Turkey (Türkiye)
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- Ankara University
Cervical Cancer
Pilot Study of a Mobile Health Approach to Reduce Barriers to Cervical Cancer Screening in Tanzania
The purpose of this study is to determine whether motivational text messages and/or travel vouchers are effective in increasing cervical cancer screening rates in urban and rural regions of Northern Tanzania.
- Trial name
- KCCPAS (NCT02680613)
- Testing
- Motivational SMS, Travel Voucher
- Where
- Tanzania
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- Queen's University
Lung Cancer
Lung EpiCheck Biomarkers Development Study
This study is part of the development of a non-invasive lung cancer screening test which aim to identify early-stage lung cancer in patients at high risk for lung cancer.
- Trial name
- NCT06245876
- Testing
- Blood collection
- Where
- 10 sites in United States, Hungary and 2 more
- Volunteers
- 2,132 people, healthy volunteers welcome
- Sponsor
- Nucleix Ltd.
Colonic Cancer
Evaluating Online Messages About Colon Cancer Screening
The goal of the study is to determine, using a choice-based approach, what messages (pulled from various online sites) people find more and less persuasive and shareable on the topic of colorectal cancer screening.
- Trial name
- NCT06134089
- Testing
- Perceived Effectiveness Prompt, Perceived Shareability Prompt
- Where
- United States
- Volunteers
- 2,210 people, healthy volunteers welcome
- Sponsor
- University of Utah
Endometrial Carcinoma
Development of a New Early Detection Test to Reduce Racial Disparities in Endometrial Cancer (EC) Death Rates
This phase I trial investigates the development of a new early detection test to reduce racial disparities in endometrial cancer death rates.
- Trial name
- NCT04474184
- Testing
- Biospecimen Collection, Focus Group, Survey Administration
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer, Breast Neoplasms
Biennial CEM in Women With a Personal History of Breast Cancer
This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in…
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Cancer Female, Neoplasms
- Trial name
- NCT06105749
- Testing
- contrast-enhanced mammography
- Where
- 6 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Wendie Berg
Injury;Sports
The Relationship of ACWR and FMS With Injury Risk in Adolescent Players
In this study, we examine how acute to chronic workload ratio and functional movement screen scores relate to injury risk in teenage athletes who play team sports.
- Trial name
- NCT06001216
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Barrett Esophagus, Barrett Adenocarcinoma
Public's Intended Uptake and Views on Organization of Esophageal Cancer Screening
Rationale: Research on novel methods to screen for esophageal adenocarcinoma (EAC) has expanded. Insight into individuals' drivers and barriers to attend screening is essential to tailor a potential new screening policy to their…
- Conditions
- Barrett Esophagus, Barrett Adenocarcinoma, Esophageal Adenocarcinoma
- Trial name
- ACCEPT-survey (NCT05690958)
- Testing
- Survey
- Where
- Netherlands
- Volunteers
- 2,088 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
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