Clinical trials: Effect Increased
Stroke
Effects of Voluntary Adjustments During Walking in Participants Post-stroke
People post-stroke retain the capacity to modify walking patterns explicitly using biofeedback and implicitly when encountering changes in the walking environment.
- Trial name
- NCT06034119
- Testing
- Split belt treadmill, Biofeedback
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Chapman University
Chronic Kidney Disease
Safety and Tolerance of Increased Doses of HRS-1780 Tablets in Healthy Subjects
This is a randomized, double-blind, placebo-controlled phase I clinical study. The primary objective is to evaluate the safety, tolerability, PK, and PD of single- and multiple-dose HRS-1780 in healthy subjects, and to evaluate…
- Trial name
- NCT05638126
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Overweight, Obese
Effects of Long Term Calorie Restriction on Sphingomyelin and Amino Acids
The effect of weight loss with long-term low calorie diet (LCD) on plasma metabolites is unknown. The aim was to examine whether a LCD-induced weight reduction results in changes in the extended plasma metabolites.
- Trial name
- NCT02081898
- Testing
- LCD
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Metabolic Syndrome X, Oxidative Stress
Effects of Wine Grape Pomace Flour Used as a Dietary Supplement on Metabolic Syndrome Components
Lifestyle modifications, including healthy food intake, exercise, and suppression of tobacco smoking, constitute the most powerful tool to fight chronic diseases.
- Trial name
- NCT02202863
- Testing
- Red wine grape pomace flour (WGPF)
- Where
- Chile
- Volunteers
- 47 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Obesity, Diet
Effect of Carbonated Soft Drinks on Appetite-Regulation
Compared to solid foods, the nutritional energy of drinks may bypass the appetite regulation leading to obesity development. Although drinks sweetened with aspartame are available the anticipated positive effect of these drinks…
- Trial name
- NCT00776971
- Testing
- Sugar-sweetened soft drink, Aspartame-sweetened soft drink, Semi-skimmed milk
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
PD - Parkinson's Disease
AR Gait Training for Parkinson's Disease
Gait disorders in Parkinson's disease (PD), particularly in complex environments or under stress, present challenges for accurate evaluation and classification, such as in cases of freezing of gait.
- Trial name
- NCT06598878
- Testing
- AR gait training
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University
ColoRectal Cancer, Colon Polyp
Withdrawal Time and Use of Wide-angle Endoscope to Increase the Adenoma Detection Rate of Screening Colonoscopy
Colonoscopy outcome is strictly related to the adenoma detection rate (ADR). An endoscopy withdrawal time >6min has been suggested to increase the ADR since it allows for thorough evaluation of the several hidden areas of the…
- Trial name
- NCT02985944
- Testing
- Colonoscopy
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- ASST Rhodense
T2D, Blood Pressure
Potatoes, Type 2 Diabetes, and Cardiometabolic Health
Type 2 diabetes (T2D) is a major chronic health condition which increases risk of coronary artery disease, frailty, cognitive decline, and mortality.
- Conditions
- T2D, Blood Pressure, Cardiometabolic Health
- Trial name
- NCT07229482
- Testing
- Controlled diet: Potato-rich healthy dietary pattern, Controlled diet: Typical Western-style dietary pattern
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Surgical Education
Effect of Artificial Intelligence-Augmented Human Instruction on Surgical Simulation Performance
At the Neurosurgical Simulation and Artificial Intelligence Learning Centre, we seek to provide surgical trainees with innovative technologies that allow them to improve their surgical technical skills in risk-free environments…
- Trial name
- NCT06273579
- Testing
- Expert instruction using AI tutor script, AI-augmented personalized expert instruction
- Where
- Canada
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- McGill University
Obese, Primiparous Women
Effect of Increased Oxytocin Doses on the Mode of Delivery in Obese Primiparous Women With Spontaneous or Induced Labour
The rate of caesarean section is higher among obese pregnant women, leading to increased morbidity in this already vulnerable population.
- Conditions
- Obese, Primiparous Women, Oxytocin
- Trial name
- PROXYMA (NCT04760496)
- Testing
- Oxytocin 4 mIU/mL, Oxytocin 2 mIU/mL
- Where
- 12 sites in France
- Volunteers
- 443 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Self Harm
PsiloIMAGINE: A Psychedelic-augmented Mental Imagery-based Intervention for Young People With Self-harm
Approximately 20% of young people experience self-harm behaviour in their lives. Self-harm can occur across different mental health disorders, and lead to negative outcomes and risk of suicide.
- Trial name
- PsiloIMAGINE (NCT06798636)
- Testing
- Psilocybin 5 mg with cognitive behavioural therapy intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Imperial College London
Post-operative Pain, Post-partum Pain
Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
To evaluate the efficacy of increased ketorolac in reducing opioid use after cesarean section.
- Conditions
- Post-operative Pain, Post-partum Pain, Cesarean Section Complications
- Trial name
- NCT03678675
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Healthy Participants
Real-Time Avatar Feedback in Virtual Reality Exercise
The goal of this study is to examine whether real-time feedback provided by a virtual trainer avatar during virtual reality (VR) exercise influences participants' exercise well-being and movement accuracy.
- Trial name
- NCT07384065
- Testing
- VR Exercise With No Avatar Feedback, VR Exercise With Verbal Avatar Feedback, VR Exercise With Verbal and Gestural Avatar Feedback
- Where
- Poland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Information Processing Institute
Postprandial Glucose Homeostasis
The Effect of an Acute Increase in Plasma IL-6 on Glucose Tolerance When a Meal is Administered Intraduodenally
The aim of the study is to investigate and clarify whether the effect of IL-6 on glucose tolerance and insulin secretion are secondary to the changes in gastric emptying.
- Trial name
- DUIL-6 (NCT03660332)
- Testing
- Infusion of a liquid meal intraduodenally
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Optic Nerve Cup, Intracranial Pressure Increase
Effect of Lithotomy Position on Optic Nerve Sheath Diameter
In this study, the effect of increased venous return and increased intra-abdominal pressure on intracranial pressure in the lithotomy position was evaluated.
- Trial name
- NCT06464419
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Lipoprotein Disorder Disease
Safety and Tolerance of Increased Doses of HRS-5346 Tablets in Healthy Subjects
This is a randomized, double-blind, placebo-controlled phase I clinical study. The primary objective is to evaluate the safety, tolerability, PK, and PD of single- and multiple-dose HRS-5346 in healthy subjects, and to evaluate…
- Trial name
- NCT06441227
- Testing
- HRS-5346 tablets
- Where
- China
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Time-restricted Feeding, Postprandial Lipemia
The Effect of Different Methods for Modulating Postprandial Fat Oxidation on Postprandial Lipemia the Next Day
Background: Studies have revealed that time-restricted feeding affects the fat oxidation rate; however, its effects on the fat oxidation rate and hyperlipidemia following high-fat meals are unclear.
- Trial name
- NCT05251103
- Testing
- time-restricted feeding trial
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Type 1 Diabetes Mellitus
Effect of CSII and CGM on Progression of Late Diabetic Complications
The purpose of the study is to investigate whether the combination of insulin pump therapy and continued glucose monitoring (CGM) is superior to multiple daily insulin injections to prevent progression of albuminuria in patients…
- Trial name
- NCT01454700
- Testing
- Insulin pump therapy (CSII) plus continuous glucose monitoring (CGM), Multiple daily insulin injections (MDI)
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Steen Andersen
Prostate Cancer, Surgery
Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy
Fluid therapy during surgery is an important factor that is related to long term mortality and morbidity and it's directly related to tissue perfusion as well.
- Conditions
- Prostate Cancer, Surgery, Fluid Overload, Lactate Blood Increase
- Trial name
- NCT07626151
- Testing
- Liberal Fluid Therapy, Restricted Fluid Therapy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nazmy Edward Seif
Intracranial Pressure Increase, Supraglottic Airway Device
Effect of Different Supralottic Airway Devicess on Optic Nerve Sheath Diameter
Direct laryngoscopy and tracheal intubation are associated with increases in intraocular pressure (IOP), intracranial pressure (ICP), heart rate (HR), and blood pressure.
- Conditions
- Intracranial Pressure Increase, Supraglottic Airway Device, Optic Nerve Sheath Diameter
- Trial name
- NCT05499754
- Testing
- pLMA: PROSEAL LARYNGEAL MASK, sLMA : SUPREMA LARYNGEAL MASK, I-jel =I-GEL
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University