Clinical trials: Ejection Fraction
Heart Failure With Preserved Ejection Fraction (HFpEF)
Study of Verinurad in Heart Failure With Preserved Ejection Fraction
International, Multicenter, Double-Blind, Placebo and Active Control Efficacy and Safety Study to Evaluate Verinurad combined with Allopurinol in Heart Failure with Preserved Ejection Fraction
- Trial name
- AMETHYST (NCT04327024)
- Testing
- Verinurad, Allopurinol
- Where
- 58 sites in United States, Argentina and 10 more
- Volunteers
- 159 people
- Sponsor
- AstraZeneca
Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
HS235 Study in Overweight and Obese Participants With Combined Pre and Post-Capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction
Study of HS235 in Overweight and Obese Participants with Combined Pre and Post-Capillary Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction
- Trial name
- NCT07123779
- Testing
- HS235
- Where
- 3 sites in United States
- Volunteers
- 126 people
- Sponsor
- 35Pharma Inc., a GSK company
Surgery
Global Longitudinal Peak Systolic Strain (GLPSS) Derived From Transesophageal Echocardiography - A Reliable Measure of Systolic Function?
Systolic function is a substantial determinant of overall hemodynamics and organ function. Therefore assessment of left ventricular systolic function (LVF) has been of central interest in Echocardiography.
- Trial name
- 2DSonTOEcho (NCT00877565)
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Heart Failure, Obstructive Sleep Apnea
Sleep Apnea in Heart Failure With Preserved Ejection Fraction
This is a prospective interventional study to better understand i) the prevalence of Obstructive Sleep Apnea (OSA) in Heart Failure with preserved Ejection Fraction (HFpEF), ii) its hemodynamic correlates, and iii) the impact of…
- Trial name
- NCT05008432
- Testing
- Home sleep apnea testing
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Ferric Carboxymaltose, Heart Failure With Reduced Ejection Fraction
Iron Intravenous Therapy in Reducing the Burden of Severe Arrhythmias in Heart Failure With Reduced Ejection Fraction
An open label,single-center, non-interventional prospective study with the aim on investigating the effect of intravenous ferric carboxymaltose in restoring iron status and reducing the risk of severe arrhythmic events in…
- Conditions
- Ferric Carboxymaltose, Heart Failure With Reduced Ejection Fraction, Arrhythmias, Cardiac
- Trial name
- RESAFE (NCT04974021)
- Testing
- Ferric carboxymaltose
- Where
- Greece
- Volunteers
- 106 people
- Sponsor
- Aristotle University Of Thessaloniki
Cardiovascular Health, Breast Cancer
JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First Year
This study focuses on male and female patients being treated for breast cancer that is positive for the HER2 receptor which requires special treatments targeting that receptor.
- Conditions
- Cardiovascular Health, Breast Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3), Cardio-oncology
- Trial name
- JUSTIFY (NCT06930521)
- Testing
- Intervention - Low Risk Group OR Intermediate Risk Group
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Women's College Hospital
Type2 Diabetes, Heart Failure With Preserved Ejection Fraction
SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan
The study team will examine the effects of SGLT2i (and SGLT2i-induced increases in plasma ketone concentrations) on skeletal muscle and cardiac ketone uptake, skeletal muscle bioenergetics, cardiopulmonary exercise capacity, and…
- Trial name
- NCT05057806
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Heart Failure With Reduced Ejection Fraction, End Stage Renal Disease on Dialysis
Empagliflozin in Heart Failure With Reduced Ejection Fraction and End Stage Renal Disease
In patients with ESRD, up to 20% of patients suffer from HFrEF, leading to significant CV morbidity and mortality. Several drug classes that provide survival benefits for patients with HFrEF, including SGLT2i, lack data regarding…
- Trial name
- EMPA-RRED (NCT06249932)
- Testing
- Empagliflozin 25 MG
- Where
- 2 sites in Taiwan
- Volunteers
- 95 people
- Sponsor
- National Taiwan University Hospital
Cardiac Output, Low
Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS)
Low cardiac output Syndrome (LCOS) is a complication that appears in approximately 20% of cardiac surgeries with extracorporeal circulation.
- Trial name
- SPARTANS (NCT04179604)
- Testing
- Levosimendan
- Where
- 9 sites in Spain
- Volunteers
- 300 people
- Sponsor
- María de los Ángeles Tena Pajuelo
Heart Failure With Preserved Ejection Fraction
Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction
To assess the impact of PADN combined with guideline-directed medical therapy (GDMT) versus a sham procedure with GDMT on clinical outcomes in heart failure (HF) patients with preserved left ventricular ejection fraction…
- Trial name
- PADN-HFpEF (NCT07331220)
- Testing
- PADN, GDMT
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Heart Failure, Heart Failure and Reduced Ejection Fraction
Selenium Intervention Registry Randomized Trial in Heart Failure
Heart failure is a serious condition in which the heart is unable to pump blood effectively, and it remains a leading cause of hospitalization and death worldwide despite advances in treatment.
- Conditions
- Heart Failure, Heart Failure and Reduced Ejection Fraction, Heart Failure and Mildly Reduced Ejection Fraction, Heart Failure and Preserved Ejection Fraction
- Trial name
- SIRI-HF (NCT07543562)
- Testing
- Selenium Supplement
- Where
- 11 sites in Norway, Sweden
- Volunteers
- 4,326 people
- Sponsor
- Skane University Hospital
Heart Failure With Preserved Ejection Fraction, Hypertension
Clinical Significance and Diagnosis of Sarcopenia in Cardiac Patients
Obesity sarcopenia, characterized by the coexistence of excess fat and muscle mass reduction, may contribute to the pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF).
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertension, Sarcopenic Obesity
- Trial name
- NCT04175080
- Where
- Poland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)
BRIDGE Trial: Embedding Consumer-grade mHealth Technologies Into Cardiac Rehabilitation
The purpose of the BRIDGE study is to learn whether supplementing traditional center-based cardiac rehabilitation (CBCR) with a mobile health technology intervention can help patients monitor their health, stay engaged in healthy…
- Conditions
- Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft Surgery (CABG), Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- BRIDGE (NCT07741396)
- Testing
- CBCR, BRIDGE mHealth intervention
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Heart Failure
Impact of Hear Failure on Lungs in Patients With Heart Failure
Heart failure (HF) is a common disease, which impacts on other organs. Despite an ongoing progress in knowledge about HF, there are still some uncharted aspects of impact of HF on respiratory system.
- Trial name
- NCT05191459
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- Medical University of Warsaw
Ventricular Dysfunction, Left, Ventricular Function, Left
Federated Learning for Point-of-Care Cardiac Ultrasound
This prospective, multicenter study will evaluate a federated machine-learning system designed to analyze focused cardiac point-of-care ultrasound examinations.
- Conditions
- Ventricular Dysfunction, Left, Ventricular Function, Left, Echocardiography, Ultrasonography
- Trial name
- FL-POCUS (NCT07800962)
- Testing
- Focused Cardiac Point-of-Care Ultrasonography, FL-POCUS Federated Machine-Learning Analysis System
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Truway Health, Inc.
Heart Failure With Preserved Ejection Fraction (HFPEF)
Effects of a Multicomponent Training Program on Cardiac Function, Skeletal Muscle Metabolism, Functional Capacity, and Quality of Life in Patients With HFpEF: SENSORFIT-4HEART Study
Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with increasing incidence and poor prognosis, accounting for up to 50% of heart failure cases.
- Trial name
- SENSORFIT-4HEA (NCT07251361)
- Testing
- Supervised training
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Chronic Kidney Disease Requiring Hemodialysis
Cardiovascular Effects of SGLT2 Inhibitors in Hemodialysis Patients: A Phase 2 Randomized Study
Patients with end-stage kidney disease (ESKD) on hemodialysis face an unacceptably high rate of cardiovascular complications, including heart failure, arrhythmias, and sudden cardiac death.
- Trial name
- SGLT2-HD (NCT06929169)
- Testing
- iSGLT2
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Maximo Agustin Schiavone
Congestive Heart Failure, Heart Failure, Systolic
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which will, in turn, translate to…
- Conditions
- Congestive Heart Failure, Heart Failure, Systolic, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction
- Trial name
- MUSIC-HFrEF1 (NCT04703842)
- Testing
- SRD-001
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- Sardocor Corp.
Heart Failure, Diastolic, Obesity
Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction)
The purpose of this study is to examine the effects of weight loss via hypocaloric diet (CR)and aerobic exercise (AT) compared to the effects of weight loss via hypocaloric diet (CR), aerobic training (AT)and resistance training…
- Trial name
- SECRET-II (NCT02636439)
- Testing
- dietary, aerobic and resistance training, dietary, and aerobic exercise
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Wake Forest University Health Sciences
Heart Failure
Real World Experience in Heart Failure With Reduced Ejection Fraction (HFrEF) Patients Treated With sAc/vaL.
The study is a cohort observational, retrospective, non-interventional study.
- Trial name
- NCT05448872
- Testing
- Sacubitril/Valsartan
- Where
- Italy
- Volunteers
- 924 people
- Sponsor
- Novartis Pharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.