Clinical trials: Elderly Cancer Patients
Ovarian Cancer
Retrospective Multicenter Study of Elderly Patients With Ovarian Cancer Treated With Trabectedin and PLD
The median age at which ovarian cancer is diagnosed is 63 years (50-75). This is still a significant adverse factor for survival results.
- Trial name
- NCT05868889
- Testing
- Trabectedin and PLD
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Grupo Español de Investigación en Cáncer de Ovario
Small Cell Lung Cancer
Adebrelimab Combined With Oral Etoposide for Elderly Patients and Patients With Poor Performance Status in Small Cell Lung Cancer: An Exploratory Clinical Study
This is a multicenter, single-arm, exploratory clinical study designed to observe and evaluate the efficacy and safety of adebrelimab combined with oral etoposide for elderly patients and patients with poor performance status in…
- Trial name
- NCT07398560
- Testing
- Adebrelimab, Oral etoposide soft capsules
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The Third Affiliated Hospital of Harbin Medical University
Geriatric Assessment, Cancer
Effect of Comprehensive Geriatric Assessment on Short-time Mortality in Elderly Cancer Patients
Older cancer patients referred to Oncology outpatient Clinic at Aarhus University Hospital have for a period been offered Comprehensive geriatric Assessment (CGA) as part of a routine practice.
- Trial name
- NCT03814213
- Testing
- CGA, tailored care
- Where
- 2 sites in Denmark
- Volunteers
- 781 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Myeloid Leukemia, Elderly
Decitabine for Chemotherapy Unfit Korean AML Patients in Real Practice
Prospective multicenter, open-lab el, observational, single arm study of decitabine. Subjects will be elderly patients with newly diagnosed, treatment-naïve AML who are unfit to receive and not candidate for intensive induction…
- Conditions
- Acute Myeloid Leukemia, Elderly, Intensive Chemotherapy Unfit
- Trial name
- PURPLE-D (NCT02698124)
- Testing
- Decitabine
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Ulsan University Hospital
Breast Cancer
FACILE: FeAsibility of First-line RiboCIclib in OLdEr Patients with Advanced Breast Cancer
Phase II, multicenter, single arm trial to assess the feasibility of first line ribociclib in combination with a non steroidal aromatase inhibitor in women or men aged 70 years-old or older, with hormone receptor positive/HER2…
- Trial name
- FACILE (NCT03944434)
- Testing
- Ribociclib, Aromatase Inhibitors, non steroideal, LHRH agonist
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- Fondazione Sandro Pitigliani
Aged Patients Treated for Cancer in Outclinics
Falls Among the Older Patients Treated for Cancer in Normandy's Outclinics: Screening and Prevention
The French Plan National AntiChute (published on February 21, 2022) and international recommendations on falls prevention (Age Ageing,September 2022) recommend identifying the risk of falling in people aged 65 and over, at least…
- Trial name
- CHUPACHOUP (NCT06504628)
- Testing
- screening risk for falling and identifiy the risk level low-intermediate-high, 3 mnth-follow-up
- Where
- 10 sites in France
- Volunteers
- 328 people
- Sponsor
- University Hospital, Caen
Geriatric Oncology, Oncology
G8, CARG, Frailty, and Nutritional Markers in Predicting Chemotoxicity
This study aims to evaluate the ability of G8, CARG, and Frailty scales to predict chemotherapy-related toxicity and the need for G-CSF in elderly cancer patients.
- Conditions
- Geriatric Oncology, Oncology, Nutrition, Nutrition Assessment
- Trial name
- NCT07151794
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Çanakkale Onsekiz Mart University
Leukemia, Lymphoblastic, Acute
"Geriatric Assessment Adapted" Therapy for Ph- ALL Elderly Patients
This study aims at considering clinical heterogeneity of patients based on a "geriatric assessment" without taking into account the real age of the subject.
- Trial name
- LAL1104 (NCT00475280)
- Testing
- Geriatric assessment adapted therapy, Stem cells autotransplantation
- Where
- 32 sites in Italy
- Volunteers
- 102 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Rectal Cancer
Organ Preservation in Elderly Patients With Rectal Cancer
In elderly patients postoperative mortality measured 3-6 months after total mesorectal excision is high. Thus, less toxic treatments may lead to a survival benefit for elderly patients even if a risk of local recurrence is…
- Trial name
- NCT01863862
- Testing
- Radiochemotherapy or radiotherapy
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Solid Carcinoma, Frailty
Geriatric Oncology Screening of Older Patients With Solid Cancers
Older patients with cancer constitute a heterogeneous group with varying comorbidity; therefore, geriatric assessment with initial screening is recommended. The Geriatric 8 (G8) has been established as a promising screening tool.
- Conditions
- Solid Carcinoma, Frailty, Age, Geriatrics
- Trial name
- PROGNOSIS-G8 (NCT04644874)
- Testing
- Geriatric 8, modified Geriatric 8, 30 second chair stand test
- Where
- Denmark
- Volunteers
- 1,401 people
- Sponsor
- Odense University Hospital
Cutaneous Squamous Cell Carcinoma
Cemiplimab and Quad Shot Radiation for Cutaneous Squamous Cell Carcinoma in the Head and Neck
The goal of this clinical trial is to learn if the combination of the drug cemiplimab along with a short course of radiation therapy called Quad Shot can be successfully given in several rounds to elderly or frail patients with…
- Trial name
- NCT07869823
- Testing
- Cemiplimab, Radiation Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Vascular Access Complication
Effectiveness of the Rapid Intravascular Start (RIVS) System Versus Conventional Catheter
The study will test a hypothesis that the RIVS system will have a higher rate of successful first PIV placement compared to conventional catheter without a significant increase in complications and time of procedure.
- Trial name
- NCT00914069
- Testing
- RIVS vascular access, Conventional vascular access
- Where
- 3 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- C. R. Bard
Breast Cancer
Doxorubicin Hydrochloride Liposome as First-Line Therapy in Treating Older Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00960336
- Testing
- pegylated liposomal doxorubicin hydrochloride
- Where
- France
- Volunteers
- 59 people
- Sponsor
- ARCAGY/ GINECO GROUP
Cancer, Death
Evaluation of Rumination, Frailty and Tanatophobia in Cancer Patients Over 65 Years of Age
The aim of this study is to evaluate tanatophobia and rumination in individuals over 65 years of age receiving cancer chemotherapy and to determine the related factors.
- Conditions
- Cancer, Death, Rumination, Frailty
- Trial name
- CANFRADE (NCT05350007)
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Multiple Myeloma, Plasma Cell Myeloma
S0833, Bortezomib, Thalidomide, Lenalidomide, Combination Chemotherapy, and Autologous Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as thalidomide and lenalidomide, may stimulate the immune system in different ways and…
- Trial name
- NCT01055301
- Testing
- bortezomib, cisplatin, cyclophosphamide
- Where
- 21 sites in United States
- Sponsor
- SWOG Cancer Research Network
Breast Neoplasms
Influence of Exceptional Patient Characteristics on Everolimus Exposure
A study to determine whether everolimus pharmacokinetics in elderly and obese patients is different compared to control patients.
- Trial name
- INPRES (NCT01948960)
- Testing
- everolimus dose escalation
- Where
- 7 sites in Netherlands
- Volunteers
- 56 people
- Sponsor
- Radboud University Medical Center
Non-small Cell Lung Cancer
A Study of PC Sequential Pemetrexed Single Drug Maintenance Treatment for NSCLC and Related Predictive Biomarkers
PFS
- Trial name
- NCT01860508
- Testing
- pemetrexed /carboplatin
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Fudan University
Acute Myeloid Leukemia
Decitabine and Plerixafor in Elderly Acute Myeloid Leukemia (AML)
The hypothesis of this proposal is that combining plerixafor, an inhibitor of stromal cell derived factor - 1α (SDF-1α), with decitabine, a DNA methyltransferase inhibitor, as induction and postremission therapy for older…
- Trial name
- NCT01352650
- Testing
- plerixafor, decitabine
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Weill Medical College of Cornell University
Sepsis, Cancer
Sepsis As a Cause of Death Among Elderly Cancer Patients
The goal of this retrospective study is to explore the association between sepsis and morality among the elderly cancer patients.
- Trial name
- NCT06619535
- Where
- Egypt
- Volunteers
- 5,239,194 people
- Sponsor
- asmaa salama ibrahim
Multiple Myeloma in Older Patients
Vulnerability and Therapeutic Changes in Older Patients With Multiple Myeloma.
The aim of this study is to determine whether the presence of vulnerability detected by geriatricians is associated with treatment discontinuation in older patient.
- Trial name
- MYELOME-PA (NCT02063113)
- Testing
- Vulnerability and therapeutic changes in older patients with multiple myeloma.
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- Nantes University Hospital
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