Clinical trials: Elderly Cancer Patients
Gastric Cancer
Evaluation of Efficacy and Safety of FOLFIRI Association Treatment in Patients 70 Years of Age and Older With Gastric Cancer
The number of patients over 70 years old with cancer is increasing in France. This population is heterogenous: physiological functions, presence of co-morbidities, and autonomy can vary a lot between subjects of the same age.
- Trial name
- CEPAFIRI (NCT00210184)
- Testing
- Irinotecan associated to fluorouracil and leucovorin
- Where
- 6 sites in France
- Volunteers
- 42 people
- Sponsor
- Institut Bergonié
Acute Myeloid Leukaemia; Myelodysplastic Syndromes;Chronic Myelomonocytic Leukemia
Azacytidine + HAG Regimen vs. Azacytidine for Elderly Patients With Newly Diagnosed Myeloid Malignancy
The primary objective is to explore the efficacy and safety of azacytidine and HAG regimen versus azacytidine for elderly patients with Newly Diagnosed MDS/AML/CMML in China.
- Trial name
- NCT03873311
- Testing
- Azacytidine, HAG Regimen, Azacytidine
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Shenzhen Second People's Hospital
Leukemia, Nonlymphocytic, Acute
Therapy of Acute Myeloid Leukemia in Patients Over the Age of 60 : DA Versus Mitoxantrone With Intermittent AraC
Single Arm-Studies suggest improved remission and survival rates for a Protocol with Mitoxantron 10mg/m2 for 3 days combined with AraC 1g/m2 bid on days 1+3+5+7 compared to a conventional DA 7+3 protocol (45mg/m2 Daunorubicin).
- Trial name
- NCT00180167
- Testing
- randomization between two established Chemotherapies
- Where
- Germany
- Volunteers
- 492 people
- Sponsor
- Technische Universität Dresden
Lymphoma
Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing…
- Trial name
- NCT00052936
- Testing
- filgrastim, rituximab, CHOP regimen
- Where
- 174 sites in Germany, Switzerland
- Volunteers
- 1,506 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Acute Myeloid Leukemia (AML)
Treatment of Elderly AML Patients With Induction Chemotherapy Followed by G-CSF-Mobilized Stem Cells From Haploidentical Related Donors
The purpose of this study is to test a method of bone marrow transplantation that results in only temporary donor immune function.
- Trial name
- NCT02519712
- Testing
- Induction Chemotherapy, G-PBSC Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Regional Anaesthesia, Transversus Abdominis Plane Block (TAP Block)
Transversus Abdominis Plane Block on Postoperative Analgesic Efficacy in Elderly Patients Undergoing Minimally Invasive Gastrointestinal Tumor Surgery
Elderly patients undergoing minimally invasive gastrointestinal tumor surgery face complex postoperative pain management due to age-related physiological decline and surgical particularities, where traditional opioids are prone…
- Conditions
- Regional Anaesthesia, Transversus Abdominis Plane Block (TAP Block), Pain, Postoperative
- Trial name
- NCT07013721
- Testing
- Transversus Abdominis Plane Block, TAPB
- Volunteers
- 102 people
- Sponsor
- Chinese PLA General Hospital
Diffuse Large B-Cell Lymphoma
Study of Bendamustine and Ofatumumab in Elderly Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma Who Are Poor Candidates for R-CHOP Chemotherapy
This is a single-arm, Phase II study designed to enroll and treat up to 64 patients. All patients in this study will receive ofatumumab and bendamustine as an IV infusion for 6 cycles (a cycle is defined as 21 days in length).
- Trial name
- NCT01626352
- Testing
- Bendamustine, Ofatumumab
- Where
- 11 sites in United States
- Volunteers
- 22 people
- Sponsor
- SCRI Development Innovations, LLC
Non-small Cell Lung Cancer Stage III
Sequential Chemo-immunotherapy Plus Thoracic Radiotherapy for Elderly And/or Frail Stage III Non-small-cell Lung Cancer
Concurrent chemoradiotherapy without disease progression followed by consolidation durvalumab is standard of care for unresectable, stage III non-small-cell lung cancer (NSCLC) (the 'PACIFIC regimen').
- Trial name
- NCT05557552
- Testing
- standar thoracic RT dose, decreased thoracic RT dose
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Ruijin Hospital
Stage III Non-small-cell Lung Cancer
Chemoradiation Followed by Durvalumab in Poor Risk and/or Elderly Patients With Stage III NSCLC
Elderly (age 70 years or older) or >18 years old AND poor risk (ECOG 2) newly diagnosed stage IIIA-C (AJCC 8th edition) inoperable non-small cell lung cancer (NSCLC) patients are eligible to participate in this phase II open…
- Trial name
- ESR1814205 (NCT04441138)
- Testing
- Durvalumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rush University Medical Center
Carcinoma, Non-Small-Cell Lung
Biweekly Gemcitabine and Docetaxel as First Line Treatment for Advanced Disease in Elderly Non-Small Cell Lung Cancer (NSCLC) Patients
Lung cancer is one of the most common malignancies worldwide and the leading cause of cancer-related deaths in Western countries.
- Trial name
- NCT00905983
- Testing
- Gemcitabine and Docetaxel
- Where
- 11 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Arnau de Vilanova
Acute Myeloid Leukemia
Haploidentical Lymphocytes With Nivolumab/Ara-C as Consolidation in Elderly AML Patients
A phase II trial to compare the efficacy and safety of nivolumab and intermediate dose cytarabine with or without haploidentical lymphocyte infusion.
- Trial name
- NCT03381118
- Testing
- Cytarabine, Nivolumab, G-CSF mobilized HLA-haploidentical donor PBSC
- Where
- Russia
- Volunteers
- 16 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Glycopyrrolate
Effect of Perioperative Use of Glycopyrrolate on Lung Function in Patients Under General Anesthesia
Gastrointestinal tumor is one of the highest incidence of malignant tumors in our country, with the incidence increasing year by year.
- Trial name
- NCT05693246
- Testing
- Glycopyrrolate, normal saline
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Zhuan Zhang
Hodgkin Lymphoma
Adriamycin, Vinblastine, DTIC and Revlimid in Elderly Hodgkin Lymphoma Patients
The purpose of this study is to determine within the scope of the trial what the maximum tolerated dose (MTD) of lenalidomide in combination with AVD should be.
- Trial name
- AVD-Rev (NCT01056679)
- Testing
- Doxorubicine, DTIC, Lenalidomide
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Cologne
Colorectal Cancer
Outcome of Transanal Specimen Extraction Surgery for Elderly Colorectal Cancer Patients
Retrospective analysis of a cohort of elderly CRC patients (aged ≥ 65 years) underwent transanal-NOSES between August 2008 and February 2022 was constructed. Data were obtained from China NOSES Database (CNDB).
- Trial name
- NCT05744362
- Where
- China
- Volunteers
- 1,395 people
- Sponsor
- The Second Affiliated Hospital of Harbin Medical University
Leukemia, Myeloid, Acute, De Novo
Clinical Trial to Assess the Safety and Tolerability of the Combination of Low-dose Cytarabine or Azacitidine Plus Venetoclax and Quizartinib in Newly Diagnosed AML Patients Aged Equal or More Than 60 Years Old
A phase I-II trial based on the combination of three drugs regimen LDAC or Azacitidine + Venetoclax + Quizartinib that in this population could be well tolerated by a sequential type administration.
- Conditions
- Leukemia, Myeloid, Acute, De Novo, Age More 60yr
- Trial name
- NCT04687761
- Testing
- Azacitidine, Venetoclax, Quizartinib
- Where
- 15 sites in Spain
- Volunteers
- 113 people
- Sponsor
- PETHEMA Foundation
Diffuse Large B Cell Lymphoma
Study Evaluating the Safety and Efficacy of iR2 in Untreated and Unfit Elderly Patients With DLBCL
This is a single-arm, open-label phase 2 study of iR2 in the treatment of unfit and elderly patients with untreated diffuse large B-cell lymphoma。
- Trial name
- NCT03949062
- Testing
- Ibrutinib, Lenalidomide, Rituximab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Hepatic Malignancies, Comprehensive Geriatric Assessment
Preoperative Oncogeriatric Assessment in Patients Undergoing Hepatectomy
This study aims to bridge the gap between geriatric medicine and surgical oncology. The findings will provide valuable insights into optimizing perioperative care for older adults, enhancing surgical safety, and improving…
- Conditions
- Hepatic Malignancies, Comprehensive Geriatric Assessment, Hepatectomy
- Trial name
- NCT07537569
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Elderly, Cancer
Elderly CAncer Patient: Qualitative and Quantitative Factors of Inclusion Failure in Clinical Trials
The transposition of the results of biomedical research to medical management of patients in real-life setting depends highly from patient's selection.
- Conditions
- Elderly, Cancer, Ethnographic Interview, Social Representation of Being Aged
- Trial name
- Quali-SAGE (NCT03230305)
- Testing
- Ethnographic interview
- Where
- France
- Volunteers
- 313 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukemia
Gemtuzumab Ozogamicin With or Without Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Trial name
- NCT00006122
- Testing
- cytarabine, etoposide, gemtuzumab ozogamicin
- Where
- 18 sites in Austria, Belgium and 5 more
- Volunteers
- 106 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Gastric Cancer, Chemotherapy Effect
Neoadjuvant Chemotherapy Plus Surgery Versus Surgery First For Elderly Gastric Cancer Patients
The main purpose of this study is to compare the feasibility and efficacy of neoadjuvant chemotherapy (modified SOX) for elderly patients with locally advanced gastric cancer.
- Conditions
- Gastric Cancer, Chemotherapy Effect, Elderly Patients, Surgery
- Trial name
- RJGC-Senile (NCT04677673)
- Testing
- Chemotherapy, Curative gastrectomy
- Volunteers
- 232 people
- Sponsor
- BIRENDRA KUMAR SAH
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