Clinical trials: Electrical Potential
Brain Diseases
Effects of Sensory Flicker and Electrical Flicker Stimulation
The study will evaluate whether sensory flicker can modulate neural activity of deep brain regions in humans, and whether it can have relevant effects on behavior.
- Trial name
- NCT04188834
- Testing
- Customized version of DAVID device, Blackrock CereStim
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Emory University
Obesity, Weight Loss
Metabolic and Behavioural Effects of CONTRAVE as Potential Mechanisms of Weight Loss in Adults With Obesity
Obesity is a common chronic disease linked with increased risk for other illnesses and earlier death. Our team and others have shown that many bodily and psychological changes occur when individuals are on calorie-restricted…
- Conditions
- Obesity, Weight Loss, Weight Management, Dietary Intervention
- Trial name
- NCT06809166
- Testing
- Contrave, Diet Program
- Where
- 3 sites in Canada
- Volunteers
- 40 people
- Sponsor
- The Royal's Institute of Mental Health Research
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Early Switch From Controlled to Assisted Ventilation
The goal of this physiological intervention study is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation in mechanically…
- Trial name
- SWITCH-SAFE (NCT06438198)
- Testing
- Pre-specified switch from controlled to assisted ventilation when PaO2/FiO2-ratio > 200 mmHg
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Chronic Pain
Electrically Evoked Compound Action Potentials Human Observation Medtronic System Study (ECHO-MDT)
This is a prospective, multi-center, non-significant risk IDE study of evoked waveforms resulting from stimulation of the dorsal column using a closed-loop system.
- Trial name
- ECHO-MDT (NCT06499220)
- Testing
- Spinal Cord Stimulator
- Where
- 10 sites in United States
- Volunteers
- 201 people
- Sponsor
- MedtronicNeuro
Vagus Nerve Stimulation
Recording Cutaneous Vagal Nerve Activity With Multi-Electrode Array (MEA) in Patients Undergoing VNS Therapy
The overall purpose of the ABVN Phase 2 grant is to expand on previous work evaluating vagal nerve function. This will be accomplished through several independent, but related, studies.
- Trial name
- NCT06827548
- Testing
- Multi-Electrode Array (MEA) Recording
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
IBM, Inclusion Body Myositis
Establishing Muscle Impedance Parameters With Electrical Impedance Myography
The primary aim of this study is to assess the changes in the impedance parameters of muscles in inclusion body myositis (IBM) through electrical impedance myography (EIM), an emerging non-invasive electrodiagnostic technology.
- Trial name
- NCT03633318
- Testing
- electrical impedance myography (EIM)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yale University
Lower Back Pain Chronic
The Potential of Transcutaneous Electrical Nerve Stimulation to Improve Pain Experienced During Posterior Branch Blocks in Patients With Lumbar Posterior Joint Syndrome
Procedural pain is inadequately managed in two-thirds of patients undergoing invasive medical procedures. Several techniques exist for managing procedural pain, but they all present implementation challenges and are not without…
- Trial name
- TENS-INFIDOL (NCT07627490)
- Testing
- Stimulation with TENS, which allows the release of endorphins, Stimulation with TENS does not allow the release of endorphins, Questionnaires
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Toulouse
Sugammadex
The Effect of Sugammadex During Transcranial Electrical Motor Evoked Potential Monitoring in Spinal Surgery
Transcranial motor evoked potential (TcMEP) monitoring is conventionally performed during neurosurgical procedures without or with minimal neuromuscular blockade (NMB) because of its potential interference with signal…
- Trial name
- NCT04471376
- Testing
- Sugammadex
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Pain
Electrically Evoked Compound Action Potentials Human Observation Medtronic Algorithm Comparison Study
This is a prospective, multi-center, randomized, single-blind, cross-over, non-significant risk IDE research study to evaluate the in-clinic performance of a closed-loop algorithm in Spinal Cord Stimulation (SCS) therapy with an…
- Trial name
- ECHO-MAC (NCT04765735)
- Testing
- Open-loop testing, Closed-loop testing - External Spinal Cord Stimulator (SCS)
- Where
- 9 sites in United States
- Volunteers
- 52 people
- Sponsor
- MedtronicNeuro
Healthy Volunteers (HV)
Electrical Nerve Stimulation During Sleep for Memory Consolidation
The purpose of this study is to investigate the effects of transcutaneous electrical nerve stimulation (eTNS) applied during sleep on memory consolidation and brain-body physiological coupling.
- Trial name
- NCT07658274
- Testing
- 120 Hz Transcutaneous Electrical Nerve Stimulation, 2 Hz Transcutaneous Electrical Nerve Stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xidian University
Hypertension
ConfidenHT System for Diagnostic Electrical Mapping of Renal Nerves
To evaluate the safety and performance of the ConfidenHT System
- Trial name
- RDN (NCT02777216)
- Testing
- ConfidenHT system
- Where
- 3 sites in Greece, Netherlands
- Volunteers
- 20 people
- Sponsor
- BlueWind Medical
Healthy State
Measuring Skin Electrical Potential With the Kelvin Probe: Minimizing Noise
The Scanning Kelvin Probe measures surface electrical potential without actually touching the skin. This is a pilot study to evaluate methods of minimizing noise during Scanning Kelvin Probe measurements.
- Trial name
- NCT01399879
- Testing
- Faraday cage, movement stabilization
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hemorrhagic Stroke, Ischemic Stroke
Effects of tES Combined With CMDT Gait Training on Cognition, Cortical Activity, Spinal Motoneuron Excitability and Motor Performance in Stroke Individuals
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and…
- Conditions
- Hemorrhagic Stroke, Ischemic Stroke, Subacute Stroke, Chronic Stroke Patient
- Trial name
- NCT07236216
- Testing
- High-definition transcranial direct current stimulation (Active), High-definition transcranial alternating stimulation (Active), Cognitive-motor dual task gait training
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Acute Hypoxemic Respiratory Failure, Ventilation, Mechanical
Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure
This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation.
- Trial name
- TAC-EIT-20-5 (NCT07175194)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Heart Diseases, Cardiac Conduction Defect
Developing Methods for Reconstructing Electrical Heart Activity
Non-invasive reconstruction of electrical heart activity can yield important scientific and clinical insights in cardiac rhythm disorders.
- Trial name
- NCT03947021
- Testing
- Computed tomography (CT) scan, Body-surface potential mapping
- Where
- Netherlands
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Nitric Oxide, Acute Respiratory Distress Syndrome
Potential for Inhaled Nitric Oxide and Ventilation-Perfusion Mismatch by Electrical Impedance Tomography in the ARDS Patients With Lung Recruitment
In the recent years, the treatment of Acute Respiratory Distress Syndrome has been proved that lung recruitment re-opens the non-ventilated alveolar to improve ventilation, and inhaled Nitric Oxide dilates non-perfused pulmonary…
- Trial name
- NCT04776408
- Testing
- Lung recruitment combined inhaled Nitric oxide, Lung recruitment
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
Surgery
The Effect of Increasing Current or Pulse Duration on Patient Movement and Intraoperative Transcranial Electric Stimulation Motor Evoked Potential Amplitude
Transcranial electric stimulation (TES) motor evoked potential (MEP) monitoring is standard during surgery risking motor system injury. The stimuli are typically 5-pulse trains with a 4 ms interstimulus interval (ISI).
- Trial name
- CCCV (NCT05375669)
- Testing
- ISIS IOM System
- Where
- Switzerland
- Volunteers
- 31 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Healthy Subjects
ABVN Phase 2 - PENFS
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN2 (NCT07856446)
- Testing
- Percutaneous Electrical Nerve Field Stimulation (PENFS)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Indiana University
Atrial Fibrillation
Impact of Intravenous Caffeine on Atrial Electrical Properties and Potential Arrythmia Induction
This "How caffeine Induces Atrial Tachyarrhythmias" trial will be a multi-center, randomized, double-blinded trial of intravenous caffeine versus placebo among patients undergoing pulmonary vein isolation procedures for Atrial…
- Trial name
- NCT05464940
- Testing
- Intravenous caffeine
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Healthy Individuals, Skin Electrical Potential
Understanding the Physiological Implications of Scanning Kelvin Probe Measurements
The purpose of this study is to evaluate the effects of skin thickness, skin moisture, and sweat gland density on Scanning Kelvin Probe measurements.
- Trial name
- NCT01545973
- Testing
- Skin Moistening, Skin Denuding
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital