Clinical trials: Electrophysiology
High Degree Second Degree Atrioventricular Block, Complete Heart Block
RAFT-TAVR PACE: LBBAP vs. RVP Post-TAVR in Patients Requiring PPI
The RAFT-TAVR PACE study is a clinical trial designed to compare two types of heart pacing methods in patients who develop conduction problems after undergoing a transcatheter aortic valve replacement (TAVR) procedure.
- Conditions
- High Degree Second Degree Atrioventricular Block, Complete Heart Block, Heart Failure, Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- RAFT-TAVR PACE (NCT06857201)
- Testing
- Left Bundle Branch Area Pacing, Right Ventricular Pacing
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Radial Tunnel Syndrome, Lateral Epicondylitis
Radial Tunnel Syndrome in Resistant Lateral Epicondylitis
Lateral elbow pain can be difficult to diagnose because of the different pathologies or combinations of pathologies that can cause this clinic.
- Conditions
- Radial Tunnel Syndrome, Lateral Epicondylitis, Radial Nerve Compression, Epicondylitis of the Elbow
- Trial name
- NCT04856228
- Testing
- diagnostic posterior interosseous nerve lidocaine injection
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Epilepsy
Human Intracranial Electrophysiology
This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp.
- Trial name
- NCT05529264
- Testing
- Memory Tasks, Attention/arousal tasks, Language tasks
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Atrial Fibrillation
Enhanced Diagnostics for Early Detection of Atrial Fibrillation
Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present. The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display…
- Trial name
- DETECT-AF (NCT02270112)
- Testing
- ECG
- Where
- Switzerland
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Schizophrenia
Add On Treatment for Cognitive Deficits in Schizophrenia
This study will look at the impact of dosing as well as ongoing treatment with an investigation medication identified as PF-03654746, on cognitive and physiologic indicators of brain function.
- Trial name
- NCT01346163
- Testing
- PF 03654746
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pennsylvania
Refractory Frontal Lobe Epilepsy
Transcranial Magnetic Stimulation and Anti-epileptic Effect: Optimization and Evaluation With Electrophysiology.
Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy.
- Trial name
- NCT00382707
- Testing
- cortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull.
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France
Scleroderma, Hand Functionality
Ultrasound and Electrophysiology Study of Hand in Systemic Sclerosis Patients and Contributors of Hand Dysfunction
The goal of this research is to assess quality of life and hand function in systemic sclerosis patients via specific questionnaires, and to determine the main contributors to hand dysfunction via a thorough hand ultrasound study…
- Conditions
- Scleroderma, Hand Functionality, Quality of Life (QOL)
- Trial name
- NCT06776575
- Volunteers
- 45 people
- Sponsor
- Assiut University
Paroxysmal Atrial Fibrillation, Atrial Fibrillation
DiamondTemp™ Ablation System for the Treatment of Paroxysmal Atrial Fibrillation
The purpose of the DIAMOND-AF study is to establish the safety and effectiveness of the DiamondTemp System for the treatment of drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation in patients.
- Trial name
- DIAMOND-AF (NCT03334630)
- Testing
- DiamondTemp Ablation catheter, TactiCath Quartz Ablation catheter
- Where
- 23 sites in United States, Canada and 3 more
- Volunteers
- 482 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Congenital Cataract
Electrophysiology in Congenital Cataract After Lensectomy and Anterior
In this prospective study , a cohort of 91 eyes with congenital cataract and 25 eyes normal eyes from Wenzhou medical university was erolled.91 eyes with congenital cataract was after lensectomy and anterior vitrectomy as test…
- Trial name
- NCT04427748
- Where
- China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Left Bundle Branch Block, Transcatheter Aortic Valve Replacement
HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients
TAVI induced LBBB is a complication that occurs between 7 and 65 % of the cases, numbers that differ considerably between devices.
- Conditions
- Left Bundle Branch Block, Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation
- Trial name
- HESITATE (NCT02659137)
- Testing
- HV measurement
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
H-reflex, Spinal Reflexes
H-Reflex Suppression by Bone Myoregulation Reflex During Mechanical Loading in Standing Humans
This study aims to investigate how standing posture and mechanical loading affect reflex responses in the lower limb. Specifically, it focuses on the H-reflex-a type of spinal cord reflex-and how it changes during quiet standing…
- Conditions
- H-reflex, Spinal Reflexes, Posture, Weight-Bearing
- Trial name
- BMR-HREF (NCT07043595)
- Testing
- Whole-Body Vibration (WBV)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Psychiatric Disorder
HNC: Human Neural Circuits Electrophysiology During Cognition
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
- Trial name
- NCT05962424
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Atypical Atrial Flutter, Atrial Flutter
Pulsed-Field Ablation for Recurrent Atypical Atrial Flutter
Recurrent atypical atrial flutter (AFL) after prior atrial fibrillation or flutter ablation remains challenging to treat, and conventional radiofrequency ablation may be limited by incomplete lesion formation and risk of…
- Trial name
- NCT07362134
- Testing
- Point-by-point pulsed-field catheter ablation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Atrial Fibrillation, Arrhythmias, Cardiac
Cloud-Based Mapping for Personalized Ablation
Atrial fibrillation is a serious public health issue that affects over 5 million Americans in whom it may cause skipped beats, dizziness, stroke and even death.
- Trial name
- NCT04127123
- Where
- United States
- Sponsor
- Stanford University
Spinal Cord Disease
Combination of Multiparametric MRI and Electrophysiology for the Development of New Biomarkers in Spinal Cord Diseases
The spinal cord is a common site for the development of several neurodegenerative neurological disorders (spinal muscular atrophy or SMA, amyotrophic lateral sclerosis or ALS, X-linked spinal bulbar muscular atrophy or SBMA).
- Trial name
- SPINE2 (NCT02885870)
- Testing
- Combination of multiparametric MRI and electrophysiology
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche sur la Moelle épinière et l'Encéphale
Fear, PTSD
Investigations of Amygdala Function Using Neurophysiological Recording and Stimulation
This study aims to specifically examine the in vivo electrophysiology and effects of direct stimulation of the human amygdala during conditioned and evoked fear.
- Conditions
- Fear, PTSD, Panic Disorder
- Trial name
- NCT03958903
- Testing
- Amygdala recording and stimulation using Neuropace RNS, Behavioral tasks
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Ventricular Tachycardia, Ischemic
Early Ablation Therapy for the Treatment of Ischemic Ventricular Tachycardia in Patients With Implantable Cardioverter Defibrillators
The purpose of this study is to determine if early ablation (i.e., ablation of ventricular tachycardia in patients with infrequent VT episodes) is more effective than medical therapy alone for the treatment of ischemic…
- Trial name
- ASPIRE (NCT01557842)
- Testing
- Drug Treatment, Catheter Ablation
- Where
- 23 sites in United States
- Volunteers
- 15 people
- Sponsor
- Biosense Webster, Inc.
Schizophrenia
The Effect of tDCS on Schizophrenia With Negative Symptoms
The investigators conducted a randomized controlled trial to reveal the effect of tDCS on negative symptoms in patients with schizophrenia and its underlying mechanism using the neuroimaging and electrophysiology.
- Trial name
- NCT03729791
- Testing
- tDCS
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cardiac Electrophysiology, Electrocardiogram
Evaluation of Non-invasive Measurement of Electrophysiological "HV" Interval Using a High-density and High-fidelity Signal Averaging ECG Device
His-Ventricle (HV) measurement is only obtained invasively using transvenous catheters. This kind of procedure is routinely performed but some risks of complication exist.
- Trial name
- BIOSEMI-HV (NCT04138797)
- Testing
- Electrophysiological exploration, ECG Biosemi
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Neurological Disorder
Chart Review: Central Motor Conduction Time in Neurological Disorders
Background: TMS stands for transcranial magnetic stimulation. It is a non-invasive way to stimulate the brain. It helps researchers study the nervous system. TMS can assess central motor conduction time (CMCT).
- Trial name
- NCT03300856
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)