Clinical trials: Elevated Risk of Cardiovascular Disease
Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD)
Fexuprazan for Prevention of Upper Gastrointestinal Bleeding in High Bleeding Risk Patients Receiving Dual Antiplatelet Therapy
This study evaluates whether fexuprazan is effective in preventing upper gastrointestinal bleeding and related upper gastrointestinal clinical events in high bleeding risk patients who require dual antiplatelet therapy after…
- Trial name
- SAINT-FEXUDAPT (NCT07479056)
- Testing
- Fexuprazan 40mg, Lansoprazole 30mg
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- SUK MIN SEO
Cardiovascular Disease
Clinical Study to Assess High-DHA Fish Oil on Biomarkers of Cardiovascular Disease Risk in Adults on Statin Therapy
The objective of this study is to determine the acute and chronic [4-week] effects of a high-DHA fish oil supplement on fasting and post-prandial (post-meal) biomarkers of cardiovascular disease risk, in adults on Statin therapy.
- Trial name
- NCT01690312
- Testing
- Fish Oil
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Nutrasource Pharmaceutical and Nutraceutical Services, Inc.
Multiple Myeloma
Selinexor Plus VRd in High Risk Newly Diagnosed Multiple Myeloma
This is a single-arm and open-label study to explore XVRd (ATG-010, Bortezomib, Lenalidomide and Dexamethasone) regimen in high-risk newly diagnosed multiple myeloma.The primary objective of the dose escalation study is to…
- Trial name
- NCT05422027
- Testing
- Selinexor, Bortezomib, Lenalidomide
- Where
- 4 sites in China
- Volunteers
- 42 people
- Sponsor
- Xia Zhongjun
Overweight, Obesity
The Impact of Stationary Combined Exercise on Adiponectin and Hs-CRP Levels in Overweight Women
This study looked at whether a specific exercise program can improve inflammatory markers in overweight young women. We tested an eight-week, circuit-style exercise program that combines aerobic and resistance activities (e.g.…
- Conditions
- Overweight, Obesity, Inflammation, Low-Grade, Cardiovascular Diseases, Risk Factors
- Trial name
- SCEX-ADCRP (NCT07230873)
- Testing
- Combined Exercise Group, No Structured Exercise
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Xianjie Zheng
Heart Diseases, Coronary Artery Disease (CAD)
Feasibility Study SA of the Supira System for HRPCI
The objective is to assess the feasibility and safety of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing high-risk percutaneous interventions (HRPCI).
- Conditions
- Heart Diseases, Coronary Artery Disease (CAD), Heart Failure
- Trial name
- NCT05864248
- Testing
- Supira System
- Where
- 2 sites in Brazil
- Volunteers
- 71 people
- Sponsor
- Supira Medical
Obesity
Virtual Lifestyle Management: Prevention Through the UPMC Patient Portal
Diabetes affects 18 million Americans and costs over $132 billion in both direct treatment and lost productivity per year. It is known that weight loss, improved diet and increased exercise can result in improvement in glucose…
- Trial name
- NCT00409786
- Testing
- Virtual Lifestyle Management (VLM)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Hyperlipidemia
Randomized Clinical Trial Of Bococizumab (PF-04950615; RN316) In Subjects With Hyperlipidemia Or Mixed Dyslipidemia At Risk Of Cardiovascular Events
This study is a multicenter, randomized study in subjects with high cholesterol receiving highly effective statins to assess the efficacy, safety and tolerability of Bococizumab (PF-04950615;RN316) to lower LDL-C.
- Trial name
- SPIRE-HR (NCT01968954)
- Testing
- Bococizumab (PF-04950615;RN316)
- Where
- 103 sites in United States, Australia and 7 more
- Volunteers
- 711 people
- Sponsor
- Pfizer
Coronary Artery Disease (CAD)
BASel Kosten-Effektivitäts-Trial: Drug-coated BALLoon (DCB) vs. Drug-eluting Stent (DES) Strategy in High-risk Patients With Coronary Artery Disease (CAD)
The main objective of this randomized, multicenter, international, open-label clinical trial is to demonstrate that, in the context of percutaneous coronary intervention for complex coronary artery disease, a SeQuent® SCB…
- Trial name
- BASKET BALL (NCT07363161)
- Testing
- PCI
- Where
- 3 sites in Germany, Switzerland
- Volunteers
- 2,184 people
- Sponsor
- B. Braun Melsungen AG
Cardiovascular Disease, Acute Kidney Injury
Study to Evaluate the Use of RenalGuard to Protect Patients at High Risk of AKI
The Strength study aim to evaluate the use of the RenalGuard device to protect the patients at high risk to develop acute kidney injury following a complex cardiovascular intervention requiring a high volume of contrast.
- Trial name
- STRENGTH (NCT02793661)
- Testing
- RenalGuard, Control
- Where
- 7 sites in France, Germany
- Volunteers
- 300 people
- Sponsor
- European Cardiovascular Research Center
Cardiovascular Disease
Effect of Fruit and Vegetables on Insulin Resistance
Current evidence indicates that fruit and vegetable intake and dietary patterns rich in fruit and vegetables may be associated with reduced insulin resistance and may reduce the risk of the metabolic syndrome.
- Trial name
- FIRST (NCT00874341)
- Testing
- Fruit and vegetable intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Brain and Central Nervous System Tumors, Thromboembolism
Risk Factors for Developing a Blood Clot in Patients Who Are Undergoing Cancer Treatment for Newly Diagnosed Gliomas
RATIONALE: Patients with gliomas may be at risk for developing blood clots. Learning about the risk factors for developing blood clots may help doctors plan better treatment for gliomas.
- Trial name
- NCT00253669
- Testing
- laboratory biomarker analysis, physiologic testing, management of therapy complications
- Where
- 9 sites in United States
- Volunteers
- 110 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Hypertension, Vascular Disease
Real-World Validation of A Minimally Disruptive Ambulatory Blood Pressure Monitoring (ABPM) Huawei Smartwatch in Malaysia
Background: Ambulatory Blood Pressure Monitoring (ABPM) is the gold standard for diagnosing high blood pressure (hypertension) because it tracks blood pressure continuously across day and night.
- Conditions
- Hypertension, Vascular Disease, Cardiovascular (CV) Risk, Cardiovascular Disease
- Trial name
- Huawei-SunU02 (NCT07913607)
- Where
- Malaysia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sunway University
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies
This study will determine the safety and applicability of experimental forms of umbilical cord blood (UCB) transplantation for patients with high risk hematologic malignancies who might benefit from a hematopoietic stem cell…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT01652014
- Testing
- cyclophosphamide, fludarabine phosphate, mycophenolate mofetil
- Where
- United States
- Sponsor
- University of Medicine and Dentistry of New Jersey
Cryptogenic Stroke, High Risk Patent Foramen Ovale
Evaluation of Prevalence and Clinical Impact of Atrial Fibrillation in Elderly Patients With Cryptogenic Stroke and High-Risk Patent Foramen Ovale
The purpose of DEFENSE-ELDERLY is to identify the prevalence of AF and evaluate the clinical impact of AF in elderly ESUS patients and no other known sources of stroke besides a high-risk patent foramen ovale, and compare it with…
- Trial name
- DefenseElderly (NCT04285918)
- Testing
- Percutaneous device closure
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Mild Cognitive Impairment, Alzheimer's Disease
Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training
The purpose of this pilot study will be to test whether Kundalini yoga (KY) and Kirtan Kriya (KK) yogic meditation is superior to Memory Enhancement Training (MET) for improving cognitive functioning, health (including…
- Trial name
- NCT03503669
- Testing
- Memory Training, Kundalini yoga and meditation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Cholesterol, Elevated, Diabetes Mellitus
Community Intervention to Improve CVD Risk Factor Control in Young American Indians
American Indians are more likely to die from heart disease compared to other people in the United States. High levels of fat (lipids) and sugar (glucose) in the blood are related to heart disease.
- Trial name
- CIRCLE (NCT06230705)
- Testing
- Guided management, Self management
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Oklahoma
Cardiovascular Diseases, Heart Diseases
Physical Training and Blood Pressure in High Risk Youths
To determine the effects of physical activity on blood pressure and body fat in children varying in ethnicity, gender, and health status.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Obesity
- Trial name
- NCT00005695
- Sponsor
- Augusta University
Multiple Myeloma
Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)
The PROMISE Study aims to establish a prospective cohort of individuals with precursor conditions to multiple myeloma, such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).
- Trial name
- NCT03689595
- Testing
- Samples of blood (2-4 tablespoons) from 4 tubes will be collected -Analysis will be performed on the blood to test for multiple myeloma precursor conditions.
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Neoplasms
A Study to Evaluate the Efficacy and Safety of Rivaroxaban Venous Thromboembolism (VTE) Prophylaxis in Ambulatory Cancer Participants
The purpose of this study is to demonstrate that rivaroxaban is superior to placebo for reducing the risk of the primary composite outcome as defined by objectively confirmed symptomatic lower extremity proximal deep vein…
- Trial name
- NCT02555878
- Testing
- Rivaroxaban
- Where
- 151 sites in United States, Belgium and 8 more
- Volunteers
- 841 people
- Sponsor
- Janssen Research & Development, LLC
Type 2 Diabetes Mellitus, Cardiovascular Disease
The Effect of a Traditional Dietary Intervention on Diabetes Mellitus and Cardiovascular Disease Risk Factors in a First Nation Community: A Pilot Study
The purpose of this study is to evaluate whether or not a traditional First Nations diet (high protein) and/or a dietary intervention based upon current Canadian dietary recommendations (high carbohydrate/high fiber) effects risk…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
- Trial name
- SLHDP (NCT00707460)
- Testing
- Dietary Intervention (Macronutrient composition)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.