Clinical trials: End-of-life Care
Hematologic Malignancy, Myelodysplastic Syndromes
Removing Transfusion Dependence as a Barrier to Hospice Enrollment
Hospice care at the end of life (EOL) includes a multidisciplinary team that helps patients and families focus on symptom control and quality of life. For patients with "solid" (e.g.
- Conditions
- Hematologic Malignancy, Myelodysplastic Syndromes, Acute Myeloid Leukemia, Lymphoma
- Trial name
- BRUOG-407 (NCT05063591)
- Testing
- Transfusion support
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Adam Olszewski
End Stage Renal Disease (ESRD), End Stage Kidney Disease (ESRD)
Effect of a Plant-Focused Diet on Nutritional Status in Malnourished Peritoneal Dialysis Patients
The goal of this clinical trial is to determine whether a plant-focused diet improves nutritional and health outcomes of malnourished adults undergoing peritoneal dialysis (PD).
- Conditions
- End Stage Renal Disease (ESRD), End Stage Kidney Disease (ESRD), Peritoneal Dialysis (PD), Malnourished
- Trial name
- NCT07157397
- Testing
- Plant-Focused Diet Counselling, Standard Renal Diet Counselling
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- National University of Malaysia
Brain Death
Determining ICU Staffs Conceptions, Opinions, Views, Experiences and Reflection of Brain Death and Organ Donation
The study aims to gather information regarding the individual perceptions, opinions, beliefs, and conceptual understanding of healthcare professionals working in the intensive care units at the University Hospital Basel, the…
- Trial name
- DISCOVER (NCT06640088)
- Where
- Switzerland
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infections, Heart Failure
Rural Hospital-Level Care at Home for Acutely Ill Adults
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infections, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05256303
- Testing
- Home Hospital care, Traditional Hospital care
- Where
- 3 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Colorectal Cancer
A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)
The purpose of this study is to assess the safety and efficacy of coformulated favezelimab/pembrolizumab (MK-4280A) in participants with metastatic colorectal cancer.
- Trial name
- NCT05064059
- Testing
- favezelimab/pembrolizumab, regorafenib, TAS-102
- Where
- 152 sites in United States, Australia and 19 more
- Volunteers
- 441 people
- Sponsor
- Merck Sharp & Dohme LLC
Advance Directives, Resuscitation Orders
Patient Understanding of End of Life Care
This study aims at assessing factors that affect patient choices for end of life care. 300 patients would be assigned either to a control arm (questionnaire alone) or intervention arm (standardized explanation+ questionnaire).
- Trial name
- NCT01683097
- Testing
- Standardized explanation
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Partners in Internal Medicine
Hospice Decision Making
Underutilization of Hospice in Older African Americans
Despite the documented benefits of hospice, less than 2 million people utilize hospice services annually. Underuse disparities are extreme across race and ethnicity as White Americans comprise 85% of all hospice enrollees.
- Trial name
- NCT04458090
- Testing
- A decision aid for patients considering Hospice care.
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
End of Life Process
Can We Improve the Quality of Care at the End of Life in Israel?
The purpose of this study is to determine whether end-of-life training of ICU professionals leads to improvements in ICU care process, teamwork and family satisfaction.
- Trial name
- ISRAEOLC (NCT02129283)
- Testing
- Simulation training
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
The Families or Next of Kin of Patients Treated at MSKCC for Non-cutaneous Squamous Cell Carcinomas of the, Upper Aerodigestive Tract
Improving End of Life Care in Head and Neck Cancer
The purpose of this study is to improve the quality of care provided for head and neck cancer patients. By better understanding the end of life experiences of dying patients and their families, the investigators hope to better…
- Trial name
- NCT01632969
- Testing
- The The Family Assessment of Treatment at the End of life (FATE ) survey
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
End-of-life, Diabetes
Diabetes and Palliative Care
Diabetes prevalence in palliative care is 10-15%. Most hospice patients are treated with insulin. The target glucose level is high in order to decrease the risk of hypoglycemia.
- Conditions
- End-of-life, Diabetes, Terminal Cancer
- Trial name
- DIAPAL (NCT02742701)
- Testing
- diagnosis
- Volunteers
- 180 people
- Sponsor
- Maison Médicale Jeanne Garnier
Chronic Obstructive Pulmonary Disease, Metastatic Cancer
Improving End-of-life Care by Continuing Medical Education and Electronic Decision Making Support for General Practitioners
Background: Optimizing the basic palliative care has been shown beneficial to patients in end-of-life care, the general practitioner (GP) having a pivotal role in the health care system, providing comprehensive and continued…
- Trial name
- NCT02050256
- Testing
- continuing medical education and electronic decision support, education and electronic support
- Where
- Denmark
- Sponsor
- University of Aarhus
Pain, Anxiety
Impact of Massage Therapy on the Quality of Life of Hospice Patients
This is a pilot study to evaluate the impact of massage therapy in hospice patients.
- Conditions
- Pain, Anxiety, Depression, Quality of Life
- Trial name
- NCT02880202
- Testing
- Massage Therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Mayo Clinic
Dyspnea
Palliative Oxygen for the Relief of Breathlessness
The main goal of this study is to establish the effectiveness of palliative oxygen in the context within which it is usually provided--relief of the sensation of breathlessness and improvement in quality of life for people with…
- Trial name
- NCT00327873
- Testing
- Oxygen, Medical Air
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 240 people
- Sponsor
- National Health and Medical Research Council, Australia
Hospital At Home, Emergency Service, Hospital
Unplanned Emergency Department Visits, Hospital Admission, or Death During Hospital-at-Home Care for Acute Infections
This is a retrospective, multicenter, non-interventional cohort study based on data derived from existing electronic medical records.
- Conditions
- Hospital At Home, Emergency Service, Hospital, Acute Infection, Treatment Failure
- Trial name
- NCT07703995
- Testing
- Integrated ED/Hospital-at-Home Model
- Where
- 3 sites in Taiwan
- Volunteers
- 447 people
- Sponsor
- Chimei Medical Center
Failure to Thrive
Palliative Care Population Management Project for Integrated Care Management Program for High-Risk Patients
The hypothesis of the Serious Illness Care Program (SICP) is that adherence to the Serious Illness Conversation Guide (SICG) portion, the SIGC, will enhance patient understanding and allow control over their own decisions…
- Trial name
- iCMP (NCT02879357)
- Testing
- Training
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Brigham and Women's Hospital
Anxiety, Depression
Improving Patient and Family Centered Care in Advanced Critical Illness
One in five deaths in the U.S. occurs in or shortly after discharge from an intensive care unit (ICU), typically following decisions made by surrogate decision makers to forego life prolonging treatment.
- Trial name
- PARTNER (NCT01844492)
- Testing
- The PARTNER Intervention, ICU Usual Care Control
- Where
- United States
- Volunteers
- 1,420 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pain
Aromatherapy Protocol for Pain Reduction in Hospice Patients
The purpose of this study is to introduce aromatherapy with current pain medication protocols to see if it improves patient satisfaction and reduces pain in hospice care patients.
- Trial name
- NCT05617144
- Testing
- Aromatherapy treatment
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
Communication, End of Life
Improving Breaking Bad News in Pediatrics by Simulated Communication
Breaking bad news, especially a death notice, is an essential part of the medical profes-sional communication. Being inadequately trained in those skills this may result in un-pleasant psychosocial consequences for everyone…
- Conditions
- Communication, End of Life, Pediatric ALL
- Trial name
- SimCom (NCT06376188)
- Testing
- communication training
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna