Clinical trials: Endarterectomy, Carotid
Regional Anesthesia Morbidity, Carotid Artery Diseases
Effect of Regional Versus General Anesthesia on Thirty-day Outcomes Following Carotid Endarterectomy: a Matched-pairs Cohort Study.
The goal of this observational study is to assess the effect of regional versus general anesthesia on carotid endarterectomy thirty-day outcomes.
- Conditions
- Regional Anesthesia Morbidity, Carotid Artery Diseases, Perioperative/Postoperative Complications
- Trial name
- NCT05706688
- Testing
- Anesthetic technique (regional versus general)
- Volunteers
- 37,204 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Carotid Endarterectomy
Vascular Post Market Review
The primary objective of this study is to confirm that properties of CardioCel provide operative benefit to surgeons when compared to Dacron, CorMatrix, and all other bovine pericardium not treated with proprietary ADAPT…
- Trial name
- NCT02681341
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor Research Institute
Atherosclerosis
Study to Determine the Effect of 14 Days Dosing With Darapladib (SB-480848) on Carotid Plague Composition in Patients With Planned Carotid Endarterectomy
The primary objective is to determine Lp-PLA2 activity in atherosclerotic carotid plaques after 14 (+/-4) days treatment with darapladib, compared to placebo.
- Trial name
- NCT01916720
- Testing
- SB-480848 40 mg, SB-480848 80 mg
- Volunteers
- 103 people
- Sponsor
- GlaxoSmithKline
Carotid Endarterectomy, Cerebral Autoregulation
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy
Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%.
- Trial name
- NCT06406842
- Testing
- Cerebral oxygenation index guided hemodynamics management
- Where
- 2 sites in China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Hypoxia, Carotid Stenosis
The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels on Cognitive Functions After Carotid Endarterectomy
In this study, we investigated the effect of the capacity to cope with oxidative stress (oxidative stress response during and after clamping) in individuals with cerebral oximetry level between 40- 60 % and above 60 % and their…
- Conditions
- Cerebral Hypoxia, Carotid Stenosis, Cognitive Dysfunction
- Trial name
- NCT05652426
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Duzce University
Carotid Atherosclerosis, Atherosclerotic Plaque
99m Tc-ANNexin-V-128 Scintigraphy for the Identification of Complicated Carotid Atherosclerotic Plaques
The aim of this trial will be to test and validate the value of scintigraphy with injection of 99mTc-Annexin-V-128 for the detection of complicated carotid plaques
- Trial name
- ANNICA (NCT03630835)
- Testing
- 99mTc-Annexin-V-128 uptake on scintigraphy
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Stenosis
Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis
The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to reduce the rate of recurrent ischemic…
- Trial name
- NCT00126139
- Testing
- Abciximab
- Where
- 5 sites in Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Carotid Stenosis, Ischemia Reperfusion Injury
Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy
The aim was the comparison of the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) during elective carotid artery stenting (CAS).
- Trial name
- NCT03410576
- Testing
- Carotid artery stenting, Carotid endarterectomy
- Where
- Hungary
- Volunteers
- 25 people
- Sponsor
- University of Pecs
Carotid Artery, Carotid Arteriosclerosis
Predicting High-Risk Carotid Plaque: Integrating radioMics and biomEchanics
Non-pharmacological interventional study for the development of a predictive model aimed at identifying unstable carotid plaques in asymptomatic patients at first diagnosis, with the use of biological material and…
- Trial name
- PRIME (NCT07877480)
- Testing
- Radiomic features analysis
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Carotid Artery Stenosis
CGUARDIANS III IDE Pivotal Trial
This is a prospective, multi-center, single-arm, pivotal study. The objective of this study is to evaluate the safety and efficacy of the SwitchGuard NPS in providing cerebral embolic protection during Transcarotid Artery…
- Trial name
- NCT07277296
- Testing
- SwitchGuardTM NPS
- Volunteers
- 103 people
- Sponsor
- InspireMD
Carotid Artery Disease, Carotid Stenosis
TRACER RGD-K5 Carotid Plaque Imaging Study
The purpose of this study is to investigate the ability of the compound[F-18]RGD-K5, when used as a tracer during PET (positron emission tomography) imaging, to detect regions of unstable atherosclerotic plaque in the carotid…
- Trial name
- TRACER (NCT01968226)
- Testing
- [F-18] RDG-K5
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Cleveland Clinic
Vasopressor Agents, Endarterectomy, Carotid
Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery
This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia.
- Conditions
- Vasopressor Agents, Endarterectomy, Carotid, Echocardiography, Transesophageal
- Trial name
- NCT00294606
- Testing
- Comparison of Effects of Phenylephrine and Norepinephrine
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Disease Management, Diabetes Complications
Determining Rates of Cardiovascular Complications Among Patients of a Managed Diabetes Care Program
The primary objective of this study is to identify whether cardiovascular complication rates are lower in patients who participate in managed diabetes care, in comparison to provincial and national rates.
- Conditions
- Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy
- Trial name
- DECIDE (NCT00498147)
- Testing
- ADEC Program
- Where
- Canada
- Volunteers
- 1,213 people
- Sponsor
- Group Health Centre
Dyslipidaemias, Carotid Artery Stenoses
Improved Medication and Care to Achieve Lipid Targets After Carotid Surgery
The goal of this clinical trial is to find out if patients who receive extra support stay on their cholesterol-lowering therapy and therefore have lower cholesterol levels after 4 months.
- Trial name
- IMACS (NCT07064135)
- Testing
- Prompt Medication Adjustment and Intensive Follow-up, Standard Care
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Barmherzige Brüder Linz
Carotid Atherosclerosis, Regional Anaesthesia Morbidity
Ultrasound-guided Intermediate Cervical Block Versus Superficial Cervical Block for Carotid Endarterectomy (CERVECHO)
The aim of this prospective, randomised, controlled study is to compare the efficacy of ultrasound-guided intermediate cervical block to superficial block for carotid endarterectomy.
- Trial name
- CERVECHO (NCT01742845)
- Testing
- Ultrasound-guided administration of ropivacaine 4.75 mg/ml, landmark based superfical ropivacaine 4.75 mg/ml injection
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Carotid Artery Thrombosis, Carotid Artery Stenosis
Randomized Clinical Trial of Polyester vs. Polyurethane Patch for Carotid Endarterectomy
This study examines the risk of thrombogenicity of the carotid patches in polyurethane compared to carotid patches in polyester including death, any stroke, carotid thrombosis at 30 days and long-term results including stroke and…
- Conditions
- Carotid Artery Thrombosis, Carotid Artery Stenosis, Stroke
- Trial name
- NCT02341196
- Testing
- CEA
- Volunteers
- 450 people
- Sponsor
- University of Poitiers
Endarterectomy, Carotid
Effects of Dexmedetomidine on the Intraoperative Electroencephalogram During Endarterectomy Surgery
During elective carotid endarterectomy surgery, dexmedetomidine, an FDA approved medication, is now given as part of our standard anesthetic regimen based upon its reported ability to decrease anesthetic requirements and improve…
- Trial name
- NCT00710437
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, Davis
Post-operative Craniotomy Patients, Carotid Endarterectomy and Carotid Artery Stenosis Patients
Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit
To assess the efficacy of an intravenous nonnarcotic pain medication on controlling patient pain. To assess the effect of an intravenous nonnarcotic pain medication on patient sedation levels in neurocritically ill patients.
- Conditions
- Post-operative Craniotomy Patients, Carotid Endarterectomy and Carotid Artery Stenosis Patients, Post-op Spine Patients Admitted to the NCCU, Endovascular Patients Undergoing Intracranial Intervention
- Trial name
- NCT01948505
- Testing
- Intravenous acetaminophen
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Utah
Stroke
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks.
- Trial name
- EVA3S-2 (NCT07054060)
- Testing
- carotid endarterectomy, Carotid artery stenting
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier St Anne
Carotid Endarterectomy
Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia
Patients undergoing carotid endarterectomy may suffer from neurologic deficits (ND) during the carotid cross-clamping due to cerebral hypoperfusion. An associated risk of postoperative stroke incidence is also well established.
- Trial name
- NCT04347785
- Testing
- carotid endarterectomy
- Where
- Portugal
- Volunteers
- 206 people
- Sponsor
- Universidade do Porto