Clinical trials: Endocrine Disorder
Pancreatic Neoplasms
Expression of Inflammatory Proteins in Pancreatic Cancer
The purpose of this trial is to investigate the expression of different inflammatory proteins in cancer and normal pancreatic tissue.
- Trial name
- NCT00551057
- Testing
- Expression type
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Diabetes, Diabetes Mellitus, Type 2
Effects of Biphasic Insulin Aspart 70/30 vs. Exenatide in Type 2 Diabetes Patients Not Reaching Blood Glucose Targets on Metformin and a Sulfonylurea.
This trial is conducted in the United States of America (USA). The study will compare A1C reduction achieved in patients receiving biphasic insulin aspart 70/30 once or twice daily to patients receiving exenatide twice daily.
- Trial name
- NCT00313001
- Testing
- biphasic insulin aspart, exenatide
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- Novo Nordisk A/S
Ovarian Neoplasm
Phase II CT-2103/Carboplatin in Ovarian Cancer
The purpose of this study is to evaluate the safety and efficacy of CT-2103 (poly(L)glutamate-paclitaxel) in combination with carboplatin for the treatment of patients with Stage III or IV ovarian or primary peritoneal cancer.
- Trial name
- NCT00069901
- Testing
- CT-2103 (poly(L)glutamate-paclitaxel), carboplatin
- Where
- 17 sites in United States
- Volunteers
- 82 people
- Sponsor
- CTI BioPharma
Diabetes Mellitus, Type 1
A Study on the Effect of 2 Pen Devices on HbA1c
The purpose of this study is to test the hypothesis that the HumaPen Memoir with memory function, when used over 24 weeks for prandial insulin injections achieves superior glycemic control, when compared to the conventional…
- Trial name
- NCT00985712
- Testing
- Insulin Lispro, Huminsulin Regular, HumaPen Memoir
- Where
- 29 sites in Germany
- Volunteers
- 263 people
- Sponsor
- Eli Lilly and Company
Diabetes
Safety and Efficacy of Single Administration of Oshadi Oral Insulin in Type I Diabetes Patients
The study will be a non-randomized, open label, single dose, single blind, placebo control, single center, single arm study in Type I diabetes patients.
- Trial name
- NCT01120912
- Testing
- Oshadi Oral Insulin
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Oshadi Drug Administration
Diabetes, Coronary Artery Disease
Epicardial Fat and Clinical Outcomes After Coronary Artery Bypass Grafting in Diabetics vs. Non Diabetics
Cardiovascular disease (CVD) is a group of diseases including both the heart and blood vessels, thereby including coronary heart disease (CHD). To date, diabetics have a higher incidence and prevalence of multivessels CHD.
- Trial name
- NCT03360981
- Testing
- Incretins
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Thyroid Nodule
Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules
Use of ethanol injection in treatment of cystic thyroid nodule
- Trial name
- NCT03257930
- Testing
- ethanol injection
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- hassan harby mohamed
Diabetic Foot Ulcer (DFU), Chronic Foot Ulcers
Rising Tide - Amniotic Tissue(s) Treatments for Chronic Diabetic Foot Ulcers
The purpose of this clinical investigation is to evaluate the safety and efficacy of Amnion/Chorion/Amnion allograft , Amnion/Chorion allograft, and/or Amnion/Amnion allograft, plus Standard of Care (SOC) each versus SOC alone in…
- Trial name
- NCT06681428
- Testing
- Allograft
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- Tides Medical
Gestational Diabetes
The Effects of Resistance Exercises in Glycemic Control of Women With Gestational Diabetes
The object of this study is to evaluate patients with a diagnosis of GD who are included in a program of RE carried out with rubber tubes, comparing the frequency of women who will use insulin in the group who will participate in…
- Trial name
- NCT00815828
- Testing
- Resistance exercises
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- University of Sao Paulo
Ovarian Carcinoma
REGorafenib vsTamoxifen in Patients With Platinum-sensitive OVARian Carcinoma and Isolated Biological Progression
The objective of this randomized phase II is to evaluate the benefit of regorafenib for ovarian patients who reported a confirmed elevated CA-125 level under surveillance or bevacizumab, compared with tamoxifen.
- Trial name
- REGOVAR (NCT02584465)
- Testing
- Tamoxifen, Regorafenib
- Where
- 21 sites in France
- Volunteers
- 68 people
- Sponsor
- ARCAGY/ GINECO GROUP
Exocrine Pancreas Carcinoma, Malignant Solid Neoplasm
Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial
This phase II ComboMATCH treatment trial evaluates the effectiveness of palbociclib and binimetinib in treating patients with RAS-mutated cancers.
- Conditions
- Exocrine Pancreas Carcinoma, Malignant Solid Neoplasm, Ovarian Low Grade Serous Adenocarcinoma, Stage IV Ovarian Cancer AJCC v8
- Trial name
- NCT05554367
- Testing
- Binimetinib, Biopsy Procedure, Biospecimen Collection
- Where
- 265 sites in United States, Puerto Rico
- Volunteers
- 199 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus, Type 2
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Canagliflozin in Older Children and Adolescents With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the pharmacokinetics (blood levels) and pharmacodynamics (the action or effects a drug has on the body) of canagliflozin in children and adolescents with type 2 diabetes mellitus aged 10…
- Trial name
- NCT02000700
- Testing
- Canagliflozin 100 mg, Canagliflozin 50 mg, Canagliflozin 300 mg
- Where
- 17 sites in United States, Brazil
- Volunteers
- 17 people
- Sponsor
- Janssen Research & Development, LLC
Pancreatic Cancer
The Role of the Tumor Microenvironment of Pancreatic Cancer to Predict Treatment Outcome
Pancreatic cancer is a highly lethal disease. Patients with resectable or borderline resectable disease may benefit from preoperative radiochemotherapy.
- Trial name
- MIPA (NCT01989000)
- Testing
- Gadobutrol, [F-18]HX4, Gemcitabine
- Where
- 2 sites in Netherlands
- Volunteers
- 47 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ovarian Cancer
ISIS 5132 in Treating Patients With Metastatic or Recurrent Ovarian Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of ISIS 5132 in treating patients who have metastatic or…
- Trial name
- NCT00003892
- Testing
- ISIS 5132
- Where
- 66 sites in United States, Canada and 1 more
- Volunteers
- 22 people
- Sponsor
- NCIC Clinical Trials Group
Obesity, Type 2 Diabetes
Characterization of Metabolic Biomarkers in Varying Subjects
Traditional dietary, lifestyle, behavioral and pharmacologic treatment strategies have proven relatively ineffective for treating obesity, and once metabolic abnormalities such as Type 2 Diabetes (T2D) develop, definitive…
- Trial name
- NCT01199692
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- CPL Associates
Psychotic Disorders, Schizophrenia
Antipsychotics and Risk of Hyperglycemic Emergencies
The purpose of this study is to determine whether the use of atypical antipsychotic medication increases the risk of hospitalization for a hyperglycemic emergency.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02582736
- Testing
- Olanzapine, Risperidone, atypical antipsychotics (other)
- Where
- Canada
- Volunteers
- 725,489 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Hyponatremia, Ascites
Tolvaptan for Hyponatremia in Cirrhotic Patients With Ascites
The purpose of the study is to investigate the efficacy and safety for the management of hyponatremia and ascites in patients with liver cirrhosis.
- Trial name
- TONIC (NCT01716611)
- Testing
- Tolvaptan
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Konkuk University Medical Center
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors
This phase I clinical trial is studying the side effects and best dose of giving gamma-secretase inhibitor RO4929097 and cediranib maleate together in treating patients with advanced solid tumors.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT01131234
- Testing
- Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Cancer, Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)
Survivors Uniting for Remote Guided Exercise
The goal of this research study is to look at how live, online group exercise compares to recorded videos for helping increase physical activity levels, improve physical fitness and quality of life, and reduce loneliness among…
- Conditions
- Cancer, Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Physical Activity, Physical Activity Behavior
- Trial name
- SURGE (NCT07290309)
- Testing
- Virtually Supervised Exercise Sessions, Asynchronous Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Colorado State University
Type 1 Diabetes, Obesity
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Ovwerweight and obesity prevalence in persons with T1D has increased, which further complicates management and risk for complications.
- Trial name
- NCT05414409
- Testing
- Metformin
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Heba M. Ismail
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