Clinical trials: Endocrine System Disorder
Type 2 Diabetes Mellitus
Drug-Drug Interaction Study of Mitiglinide and Gemfibrozil
The primary objective of this study is to determine the extent of effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of mitiglinide.
- Trial name
- NCT00566865
- Testing
- gemfibrozil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Elixir Pharmaceuticals
Polycystic Ovary Syndrome, c Type Natriuretic Peptide
Comparison of Serum C Type Natriuretic Peptide Levels Between Polycystic Ovary Syndrome Patients and Healthy Women
Recent studies have shown that C natriuretic peptide is produced from granulosa cells, increasing cumulative guanosine monophosphate (cGMP) production by affecting cumulus cells through natriuretic peptide receptors.
- Conditions
- Polycystic Ovary Syndrome, c Type Natriuretic Peptide, Menstrual Irregularity, Hyperandrogenism
- Trial name
- CNP (NCT04006171)
- Testing
- C type natriuretic peptide
- Where
- Cyprus
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Pancreatectomy; Hyperglycemia, Diabete Mellitus
Glucose Metabolism After Partial Pancreatectomy
This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.
- Trial name
- NCT04409171
- Testing
- oral glucose tolerance test
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
AMH, Diet Habit
Effect of Antimullerian Hormone Levels on the Inflammatory Index, Phytochemical Index and NRF Nutrient Density
The aim of the study was to calculate the dietary inflammatory index, dietary phytochemical index and NRF nutrient density of the dietary pattern routinely consumed by women and to assess whether there is a difference between…
- Conditions
- AMH, Diet Habit, Ovarian Failure, Polycystic Ovary Syndrome
- Trial name
- AMH (NCT06426771)
- Testing
- Dietary Inflammatory Index, hormone profile
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Diabetes Mellitus, Type 1, Diabetic Retinopathy
Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM)
There is evidence from a variety of animal studies that choroidal blood flow is under neural control. Recent results in humans indicate that a light/dark transition is associated with a short lasting reduction in choroidal blood…
- Trial name
- NCT00718614
- Testing
- Light will be switched from 0.5µW/cm2/sr to 115µW/cm2/sr.
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
PreDiabetes, Obesity
Effect of Mango Consumption on Individuals with Pre-diabetes
This study is designed to explore the effect of mango consumption on glycemic indices, cardiovascular health, and body composition in overweight and obese individuals with prediabetes.
- Trial name
- NCT05571800
- Testing
- Mango
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Florida State University
Thyroid Gland Disease, Pregnancy Complications
Antithyroidal Antibodies With or Without Subclinical Hypothyroidism During Pregnancy in Infertile Women
One prospective observational study was carried out in 2009 aiming at identifying the fluctuations of the thyroid hormones in women with normal thyroid gland and in women with anti-TPO antibodies.
- Trial name
- Anti-TPO (NCT04249271)
- Testing
- serum sampling
- Where
- Switzerland
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hypertension, Diabetes Mellitus
Generative AI for Medication Counselling and Adherence in Community Pharmacies
Medication counseling within community pharmacies is crucial for managing chronic diseases, yet significant challenges regarding correctness and completeness remain in Jordan.
- Conditions
- Hypertension, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases
- Trial name
- NCT07649577
- Testing
- pharmacist-supervised AI-assisted medication counseling
- Where
- Jordan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Petra
Poly Cystic Ovary Syndrome
Inspiratory Muscle Training for the Management of Polyendocrine Metabolic Ovarian Syndrome
Inspiratory muscle training (IMT) is a relatively simple and accessible form of exercise that specifically targets the respiratory muscles and has been reported to improve inspiratory muscle strength, respiratory efficiency…
- Trial name
- NCT07871175
- Testing
- Exercise
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCL 25mg/5mg/1000mg Extended-Release Tablets Versus Trijardy® XR Extended Release Film Coated Tablets
Randomized, Single Oral Dose, Two-period, Two Sequence, Open-label, Crossover, Bioequivalence Study to Compare Empagliflozin-Linagliptin-Metformin XR Tablet 25mg/ 5mg/1000mg (25mg Empagliflozin /5mg Linagliptin /1000mgMetformin…
- Trial name
- NCT07213895
- Testing
- Empagliflozin/Linagliptin/Metformin HCL, Trijardy® XR Extended release film coated tablets
- Where
- Jordan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study)
Given that glutamate carboxylation or decarboxylation is key to the metabolic role of osteocalcin (at least in mouse models) and that carboxylation is vitamin K dependent, it is critical to isolate the effect of vitamin K…
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Beta-Cell Dysfunction
- Trial name
- NCT02366481
- Testing
- Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cardiovascular Diseases, Coronary Disease
Coronary Artery Risk Development in Young Adults
To measure changes in coronary heart disease risk factors in cohorts of Black and White males and females 18 to 30 years of age at baseline.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Hypertension, Heart Diseases
- Trial name
- CARDIA (NCT00005130)
- Volunteers
- 5,115 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Influence of Prior Walking on Postprandial Metabolism in Centrally Obese Men
The present study will investigate the effect of prior walking on postprandial metabolism and endothelial function in centrally obese South Asian and White European men.
- Conditions
- Diabetes Mellitus, Type 2, Cardiovascular Diseases, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT03952000
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Cancer, Cardiovascular Disease
Eastern Caribbean Health Outcomes Research Network (ECHORN)
The Eastern Caribbean Health Outcomes Research Network (ECHORN) is a collaborative research study that examines the lifestyles, eating habits, and health behaviors associated with cancer, diabetes and heart disease in adult men…
- Conditions
- Cancer, Cardiovascular Disease, Diabetes
- Trial name
- ECHORN (NCT01994811)
- Where
- 4 sites in Barbados, Puerto Rico and 2 more
- Volunteers
- 2,961 people, healthy volunteers welcome
- Sponsor
- Yale University
PreDiabetes
Mechanisms for Activation of Beige Adipose Tissue in Humans
Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients
- Trial name
- NCT04666636
- Testing
- Mirabegron, Mirabegron 50 MG, Mirabegron 100 mg
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Prediabetes, Hyperglycemia
Benefit of IQP-VV-102 in Reducing Postprandial Glucose Level in Overweight Caucasian Subjects
In this trial, the investigational product , the active ingredients which has been proven to reduce postprandial glucose in healthy and diabetic patients, will be tested.
- Trial name
- NCT02541344
- Testing
- Dose 1 of IQP-VV-102, Dose 2 of IQP-VV-102
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Hyperlipidemia, Diabetes Mellitus
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Metabolic Syndrome, Arterial Hypertension
- Trial name
- NCT01571609
- Testing
- first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Type 2 Diabetes Mellitus
Study to Evaluate the Potential Pharmacokinetic Interaction and Pharmacodynamic Effects on Renal Parameters of Bumetanide (1mg) and Dapagliflozin (10 mg) When Co-administered in Healthy Subjects
To assess the potential pharmacokinetic (PK) interactions of bumetanide and dapagliflozin following multiple doses of 1 mg bumetanide and 10 mg dapagliflozin in healthy subjects
- Trial name
- NCT00930865
- Testing
- Bumetanide, Dapagliflozin
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Anovulation, Polycystic Ovary Syndrome
Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
110 infertile women diagnosed as polycystic ovary syndrome (PCOS) at the age group of 20-35 distributed randomly : 55 women will receive letrozole 2.5mg twice daily orally from the 2nd day to the 6thday of the cycle for three…
- Trial name
- LVCCFOROI (NCT02551367)
- Testing
- Letrozole, Clomiphene citrate, hcg hormone
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- mostafa gomaa hamid halawa
Polycystic Ovary Syndrome
Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if the combination therapy of lifestyle intervention and use of Metformin together will improve ovulation induction and hyperandrogenemia in women with polycystic ovary syndrome, by…
- Trial name
- NCT00151411
- Testing
- Metformin, Lifestyle Intervention
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
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