Clinical trials: Endocrine System Disorder
Adiposity, Metabolic Syndrome
Meta-analysis of Low-calorie Sweetened Beverages and Cardiometabolic Outcomes
We propose to conduct a systematic literature review and meta-analysis to assess the association of low-calorie sweetened beverages (LCSBs) on cardiometabolic outcomes in prospective cohort studies.
- Conditions
- Adiposity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Diseases
- Trial name
- NCT04245826
- Testing
- Change in LCSBs Intake, Substitute LCSBs for SSBs or Water
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 2
Single, Ascending Dose, First Time in Human Study for GZR18 in Healthy Subjects
Single ascending dose first time in human study for GZR18 in healthy subjects
- Trial name
- NCT05328726
- Testing
- GZR-18
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Weight Loss, Gestational Diabetes Mellitus in Pregnancy
Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes
The goal of this clinical trial is to evaluate the effectiveness of a 6-month lifestyle intervention compared to Metformin in postpartum women who have delivered a singleton, live born infant within the last 12 weeks to 1 year…
- Conditions
- Weight Loss, Gestational Diabetes Mellitus in Pregnancy, Postpartum Care
- Trial name
- GooDMomS2 (NCT06948825)
- Testing
- Metformin Hcl 850Mg Tab, Lifestyle Intervention, Enhanced Lifestyle Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- George Washington University
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Diabetes Mellitus, Type 2
Nurse-led Continuum of Care for People With Diabetes and Pre-diabetes in Nepal
The study aims to improve diabetes prevention, access to care and advocacy through a novel cost-effective nurse-led continuum of care approach that incorporates diabetes prevention, awareness, screening and management for…
- Trial name
- NUCOD (NCT04131257)
- Testing
- Nurse-led Continuum of Care
- Volunteers
- 1,236 people, healthy volunteers welcome
- Sponsor
- Kathmandu University School of Medical Sciences
Irreversible Pulpitis, Diabetes Mellitus, Type 2
Outcome of Complete Pulpotomy in Healthy and Type 2 Diabetic Patients in Permanent Teeth With Irreversible Pulpitis
Endodontic research on the effects of DM on pulp tissues is scarce. Diabetic human and animal histological research demonstrated a decreased reparatory response in the pulp, resulting in chronic pulp inflammation and reduced…
- Conditions
- Irreversible Pulpitis, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT06586775
- Testing
- Pulpotomy
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Hiv
Innovative Strategies to Increase ART Initiation and Viral Suppression Among HIV-positive Men in Malawi
Men in Sub-Saharan Africa are less likely to test for HIV, initiate ART, and more likely to initiate ART at later stages of disease.
- Trial name
- NCT04878601
- Testing
- Home-Based ART, Facility-Based ART
- Where
- Malawi
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Single Dose Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Study Of PF-06291874 In Healthy Adult Subjects
The primary purpose of this trial is to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of PF-06291874 in healthy volunteers.
- Trial name
- NCT01794364
- Testing
- PF-06291874
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution, High-speed Multimodal Ophthalmic Imaging
Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IMA-MODE (NCT04129021)
- Testing
- High-resolution retinal imaging through adaptive optics, High-resolution retinal imaging through holographic systems
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Chronic Kidney Disease, Overactive Bladder
Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly
This study focuses on Beijing community residents aged 60 and above, aiming to understand how urinary function (like bladder or kidney function) and multiple health problems (such as high blood pressure, diabetes) affect each…
- Conditions
- Chronic Kidney Disease, Overactive Bladder, Benign Prostatic Hyperplasia, Female Pelvic Floor Dysfunction
- Trial name
- UFMR-BE (NCT07357714)
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Diabetes Mellitus, Type II
The Supplementary Effects of the Extract of Agaricus Blazei Murril on Type II Diabetes Mellitus (DM)
The purpose of this study is to examine whether the extract of the Agaricus blazei Murill mushroom is effective in the supplementary treatment of type II DM patients.
- Trial name
- NCT00131287
- Testing
- Extract of Agaricus blazei Murill
- Where
- Taiwan
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- ECbiotech Taiwan
Type 2 Diabetes Mellitus
Mitochondrial DNA Copy Number and Leukocyte Telomere Length as Biomarkers in Type 2 Diabetic Patients
Type 2 diabetes mellitus, which is characterised by a combination of insulin resistance and insufficient insulin secretion is a major contributor to the burden of morbidity and mortality worldwide.
- Trial name
- NCT05684406
- Testing
- Genotyping
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Periodontal Diseases, Type 2 Diabetes
Effect of Periodontal Treatment on Visfatin, fetuin-a and Sirtuin 1 of Patients With Periodontitis and Type 2 Diabetes
The aim of this study is to determine the concentrations of Visfatin, Fetuin-A and Sirtuin 1 in the gingival crevicular fluid and clinical periodontal parameters in diabetic and systemically healthy individuals and to determine…
- Conditions
- Periodontal Diseases, Type 2 Diabetes, Periodontitis
- Trial name
- NCT05662475
- Testing
- GCF (gingival crevicular fluid) collection, Non-surgical periodontal treatment completed in 24 hours, HbA1c level determination in blood serum
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Diabetes, Glucose Tolerance
Melatonin and Glucose Tolerance Among Individuals With a Variant of the MTNR1B Gene
The effect of 3 months of melatonin 4mg treatment on glucose tolerance in different variants of the melatonin receptor 1B gene will be evaluated.
- Trial name
- MELAG (NCT01705639)
- Testing
- Melatonin
- Where
- 2 sites in Finland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Diabetes Mellitus (Type 2)
A Study to Evaluate the Safety and Pharmacokinetics of UI087 Compared to Coadministration of UIC202506, UIC202507 and UIC202508 in Healthy Adult Volunteers Under Fasting Conditions
This study was an open-label, randomized, single-dose, 2-sequence, 2-period, crossover study to evaluate the safety and pharmacokinetics of UI087 compared to coadministration of UIC202506, UIC202507 and UIC202508 in healthy adult…
- Trial name
- NCT07548957
- Testing
- Administration of UI087, Administration of UIC202506, UIC202507, UIC202508
- Where
- South Korea
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism
Growing up With the Young Endocrine Support System (YESS!)
Transition from paediatric to adult endocrinology is a challenge for adolescents, families and doctors. Up to 25% of young adults with chronic endocrine disorders are lost to follow-up ('drop-out') once the young adult moves out…
- Conditions
- Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism, Growth Hormone Deficiency, Combined Pituitary Hormone Deficiency
- Trial name
- YESS (NCT04252001)
- Testing
- YESS! game, Snake '97, Transition-toolkit
- Where
- 7 sites in Belgium, Netherlands and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Diabetes Mellitus, Insulin-Dependent
Randomized Clinical Trial to Assess the Effectiveness of the GlucoWatch Biographer
This study will evaluate the safety and effectiveness of a continuous glucose monitor in children with Type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00069628
- Testing
- GlucoWatch® G2™ Biographer (GW2B), Continuous Glucose Monitoring System (CGMS)
- Where
- 6 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jaeb Center for Health Research
Hashimoto Disease, Treatment Levothyroxine
Effect of Treatment for Vitamin D Deficiency on Thyroid Function and Autoimmunity in Hashimoto's Thyroiditis.
The objective of this study is to evaluate the effect of vitamin D supplementation on thyroid autoimmunity, thyroid function, and other metabolic and clinical variables associated with the thyroid axis in patients with…
- Conditions
- Hashimoto Disease, Treatment Levothyroxine, Vitamin D Deficiency
- Trial name
- NCT04778865
- Testing
- Vitamin D-correction, Vitamin D-RDA
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Diabetes
Adolescent Fitness Assessment Program
The purpose of this study is to implement a peer modeling intervention to improve self-efficacy and aerobic fitness in obese youth.
- Trial name
- AFAP (NCT01382121)
- Testing
- Peer Modeling, Control
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Obesity, Diabetes
Fuel Utilization, Diet Composition, and Exercise in African American Women
African American women have a high prevalence of obesity and type 2 diabetes and do not optimally burn fat and carbohydrates in response to changes in these nutrients in their diets.
- Conditions
- Obesity, Diabetes, Insulin Resistance
- Trial name
- NCT04293367
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
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