Clinical trials: Endometriosis
Endometrial Receptivity;RNA; Progesterone
Clinical Study on Endometrial Receptivity
to explore the differential expression of miRNA in the implantation window of patients with endometriosis and the time of progesterone and route of administration on planting window
- Trial name
- NCT03687021
- Testing
- Progesterone
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Endometriosis, Endometriosis-related Pain
Microbiota and Immunoassay in Women With and Without Endometriosis: a Pilot Study
Endometriosis is an estrogen-dependent chronic inflammatory disease characterized by the presence of endometrial tissue outside the uterine cavity. This pathology has a prevalence of about 5-10% in reproductive-aged women.
- Trial name
- NCT05433909
- Testing
- Blood, fecal, vaginal and endometrial liquid samples
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Endometriosis, Vitamin D Deficiency/Insufficiency
Analysis of Vitamin D and VDR Expression in Endometriosis: A Case-Control Study
The goal of this cross-sectional prospective matching study is to evaluate whether serum vitamin D levels and vitamin D receptor (VDR) expression are associated with the presence and severity of endometriosis in women of…
- Conditions
- Endometriosis, Vitamin D Deficiency/Insufficiency, Vitamin D Status
- Trial name
- NCT06289257
- Testing
- Vitamin D level, Vitamin D receptor
- Where
- Thailand
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Endometriosis, Diagnosis
Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers
This study is testing a way to diagnose endometriosis using a uterine tissue biopsy (similar to a pap smear) as opposed to undergoing laparoscopy surgery.
- Trial name
- NCT05698212
- Testing
- MetriDx
- Where
- 3 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hera Biotech, Inc.
Menstrual Problem, Quality of Life
Menstrual Wellbeing in Woman Living in Turkey; an Epidemiological Study
Women with endometriosis in our country and around the world face various difficulties during their menstrual periods in reproductive age.
- Trial name
- NCT05442541
- Testing
- not included any interventions(Evaluation of menstrual well-being in women of reproductive age, field survey study)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,829 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Endometriosis, Bone Density
BMD Alterations and Bone and Muscle Parameters During Menstrual Cessation With GnRH
The investigators aim to investigate the effect of menstrual cessation in women with endometriosis treated with GnRH analogs for 6 months on bone mineral density and bone and muscle metabolism parameters and subsequently the…
- Conditions
- Endometriosis, Bone Density, Muscle, Bone Metabolism
- Trial name
- NCT04203212
- Testing
- Goserelin Acetate
- Where
- Greece
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- 424 General Military Hospital
Recruitment
Cohort Study of Endometriosis at Different Sites
To present the clinical characteristics of pelvic or extra-pelvic endometriosis and explore the potential risk factors of pathogenesis and recurrence by comparing patients with endometriosis at different sites
- Trial name
- NCT04783623
- Testing
- Surgical endometrioma excision
- Where
- China
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Endometriosis, Endometriosis Ovary
Menstrual Blood Proteomic Profile in Women With Endometriosis (PROTEO-ENDO) Study
In this prospective case control study a total of 66 women (33 women with endometriosis) and (33 healthy women) will be recruited.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis-related Pain
- Trial name
- PROTEO-ENDO (NCT06214260)
- Testing
- Peripheral blood sample, Menstrual Blood sample
- Where
- Hong Kong
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Endometriosis
Study to Determine Intraperitoneal,Tissue, Serum Concentrations of VML-0501 Following Five Days of Daily Vaginal Single Dose of VML-0501 (100 mg Danazol), in Comparison to Oral Danazol Capsules Daily 600 mg), in Women With Signs and Symptoms of Endometriosis Undergoing Laparoscopy
A Comparative, Open-Label, Randomized, Parallel Group Study to determine Intraperitoneal fluids, tissue, and serum concentrations of VML-0501 following five days of daily vaginal applications of single dose of VML-0501 (100 mg…
- Trial name
- NCT03352076
- Testing
- Vaginal Danazol, Oral Danatrol
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Viramal Limited
Endometriosis
Spinal Cord Stimulation for Intractable Chronic Lower Abdominal Neuropathic Pain Caused by Endometriosis
Endometriosis is a chronic, inflammatory disease where endometrium-like tissue is present outside the uterus. Nerve cells in the proximity of this tissue express cytokine receptors causing a signaling cascade.
- Trial name
- NCT05558540
- Testing
- spinal cord stimulator
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Prof. Velja Mijatovic
Endometriosis
Serum and Peritoneal Fluid Bank for Endometriosis Markers
The purpose of this study is to investigate differences in protein expression profiles of blood and peritoneal fluid samples obtained from patients who do, and those who do not, have endometriosis seen during laparoscopic…
- Trial name
- NCT00194233
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cystitis, Interstitial, Dysmenorrhea
Chronic Pain Risk Associated With Menstrual Period Pain
The purpose of this study is to determine if some women with dysmenorrhea (painful periods) are at higher future risk of developing chronic pelvic pain (CPP) and if oral contraceptives (OC) can be used to reverse this chronic…
- Conditions
- Cystitis, Interstitial, Dysmenorrhea, Migraine Disorders, Pelvic Pain
- Trial name
- CRAMPP (NCT02214550)
- Testing
- cyclic microgestin 1/20, continuous microgestin 1/20
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Endometriosis
Endometriosis and Microvascular Dysfunction: Role of Inflammation
The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments…
- Trial name
- Endo3/SA2 (NCT05069740)
- Testing
- Salsalate Pill
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Endometriosis, Nerve Sheath Tumor
Learning Curve for the Visualization of Sacral Plexus on TVS
The purpose of this prospective study was to evaluate the learning curve of TVUS (transvaginal ultrasound) for the visualization of sacral nerve roots and sacral plexus on gynecological transvaginal ultrasound.
- Conditions
- Endometriosis, Nerve Sheath Tumor, Radiculopathy
- Trial name
- PlexUS (NCT06041347)
- Testing
- Transvaginal ultrasound
- Where
- Hungary
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Endometriosis, Bacterial Vaginosis
Effects of a Multi-strain Oral Probiotic on the Vaginal Microbiota Composition in Healthy Women and Women with Endometriosis
Endometriosis is a chronic inflammatory disease affecting approximately 10-15% of reproductive age women, and, in recent years, an association between this pathology and dysbiosis, either involving the gut or the genital…
- Conditions
- Endometriosis, Bacterial Vaginosis, Healthy Volunteer
- Trial name
- NCT06592976
- Testing
- Multi-strain Oral Probiotic (CDS22-formula)
- Where
- Italy
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Endometriosis Rectovaginal Septum
Laparoscopic Surgery for Severe Recto-vaginal Endometriosis
To determine the quality of life following the radical excision of recto-vaginal endometriosis.
- Trial name
- NCT02471443
- Testing
- Surgery for severe endometriosis
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Endometriosis
The Use of MicroRNAs Dysregulation as Potential Biomarkers for Effective Diagnosis of Endometriosis
OBJECTIVES : 1. To investigate the expression pattern of miRNAs operational in inflammation, angiogenesis, hypoxia, apoptosis and cell proliferation in eutopic and ectopic endometrium of patients with endometriosis and normal…
- Trial name
- ENDMET (NCT06168097)
- Testing
- 100 women undergoing surgery (laparoscopy / laparotomy) with presumed diagnosis of endometriosis, women with intraoperative and / or histopathology findings suggestive of endometriosis
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Endometriosis
Carbon Dioxide-laser Versus Harmonic Scalpel in the Treatment of Pelvic Pain Due to Endometriosis
The purpose of this study is to compare laser CO2 ablation/excision of Endometriosis (AFS stages 1-3) with excision of endometriosis using the Ethicon Harmonic ACE device.
- Trial name
- NCT02282943
- Testing
- Laser, Harmonic scalpel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mr Andrew Kent
Uterine Fibroids, Menorrhagia, Endometriosis
Study Comparing Conventional vs. Robotic-assisted Laparoscopic Hysterectomy
The purpose of this study is to compare two ways of performing laparoscopic hysterectomy - robotic-assisted vs. conventional laparoscopy.
- Trial name
- NCT00485355
- Testing
- conventional laparoscopic hysterectomy, robotic assisted laparoscopic hysterectomy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Endometrioma, Endometriosis
Laparoscopic Therapy of Endometrioma: Sclerotherapy vs Cystectomy in Patients With Unfinished Reproductive Plans
The aim of this prospective randomized study is to compare laparoscopic sclerotherapy to cystectomy in following: AMH dynamics, endometrioma recurrence, complications, pregnancy rate, assisted reproduction methods success rate…
- Trial name
- NCT05801523
- Testing
- laparoscopic ethanol sclerotherapy, laparoscopic cystectomy of endometrioma
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic