Clinical trials: Endoplasmic Reticulum Stress
Periodontitis, Gingivitis and Periodontal Diseases
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)
This observational cross-sectional study investigates the levels of mitochondria-endoplasmic reticulum contact site (MERC) proteins in saliva and gingival crevicular fluid (GCF) of individuals with different periodontal…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- EKNMERC-GCF-SL (NCT07601685)
- Testing
- ELISA Biomarker Analysis, Calcium Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Inonu University
Recurrent Pregnancy Loss, Endoplasmic Reticulum Stress
Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss
To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured.
- Trial name
- NCT04455256
- Testing
- x box binding protein
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Periodontitis, Gingivitis
Endoplasmic Reticulum Stress Response in Periodontal Disease
Periodontal disease causes inflammation and damage to the tissues that support the teeth. This study looks at whether stress inside gum cells contributes to this damage.
- Trial name
- NCT07751419
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Inonu University
Endoplasmic Reticulum Stress, Viral Infection
Modulate Cellular Stress in the Immune Cells to Reduce Rate of Symptomatic Viral Infection
To determine the efficacy of metformin in reducing the rate of symptomatic YF17D infection, and to elucidate the effects of metformin on YF17D viremia and the downstream adaptive immune response, we hereby propose a randomised…
- Conditions
- Endoplasmic Reticulum Stress, Viral Infection, Yellow Fever
- Trial name
- NCT04267809
- Testing
- Metformin Hydrochloride, Calcium and Vitamin D
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Polycystic Ovary Syndrome
Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome
The main objective of the present project is to evaluate the relevance of reticulum stress in the pathogenesis of polycystic ovary syndrome (PCOS), focusing particularly on the underlying mechanisms of insulin resistance, which…
- Trial name
- PI12/1984 (NCT02302326)
- Testing
- Metformin, Myo-inositol + folic acid
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Type 2 Diabetes, Prediabetes
The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion
Chronically elevated free fatty acids impair insulin sensitivity and insulin secretion (ie lipotoxicity) by a combination of oxidative stress, endoplasmic reticulum (ER) stress and inflammation.
- Trial name
- NCT01056497
- Testing
- alpha lipoic acid
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Covid19, Endoplasmic Reticulum Stress
High GRP78 Levels in Covid-19 Infection: A Case-Control Study
Covid-19 infection was declared a global pandemic by WHO on March 11, 2020. GRP78 protein is known to be involved in the intrusion of numerous viruses.
- Trial name
- NCT04628637
- Testing
- Serum protein level analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Effect of High Protein Diet on Endoplasmic Reticulum Stress
Effect of Protein on Endoplasmic Reticulum Stress
This study was planned to provide information about the effect of short-term high protein diet (HPD) feeding on endoplasmic reticulum stress. The definition of HPDs cannot be determined exactly.
- Trial name
- NCT06621901
- Testing
- High Protein Diet, Normal Protein Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Vasodilation, Arterial Stiffness
Targeting ER Stress in Vascular Dysfunction
Aging and obesity are both risk factors for cardiovascular disease (CVD). One process that links both of these conditions to CVD is vascular dysfunction.
- Trial name
- NCT04001647
- Testing
- Acetylcholine, Sodium Nitroprusside, Ascorbic Acid
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Colorado State University
ER Stress,, Chronic Airway Disorders,
Endoplasmic Reticulum Stress in Chronic Respiratory Diseases
Aim: To investigate whether ER stress is implicated in the pathogenesis of various pulmonary disorders Measurement: 1. Unfolded protein responses (UPRs) in blood (PBMCs)of patients 1. CHOP 2. GRP 78 and so on 2.
- Conditions
- ER Stress,, Chronic Airway Disorders,, Lung Cancer,, Interstitial Lung Diseases
- Trial name
- NCT01211015
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University
Diabetes Mellitus, Type 2, Endoplasmic Reticulum Stress
Role of Endoplasmic Reticulum Stress in the Pathophysiology of Type 2 Diabetes
The purpose of this study is to investigate whether Endoplasmic Reticulum (ER) stress pathway is activated in peripheral tissues (adipose tissue) in insulin resistant diabetic patients compared to healthy subjects normoglycemic…
- Trial name
- GLUCOSTRESS (NCT02368704)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endometriosis, Endoplasmic Reticulum Stress
Relationship Between Endoplasmic Reticulum Stress and Pain in Patients With Endometriosis
The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis.
- Conditions
- Endometriosis, Endoplasmic Reticulum Stress, Endometriosis-related Pain
- Trial name
- NCT04440397
- Testing
- xbp-1 - endometriosis patients group
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Insulin Resistance, Diabetes
Effect of Endoplasmic Reticulum Stress on Metabolic Function
Normally, the hormone insulin works to help keep blood sugar normal. However, as a person gains weight, insulin does not work as well and blood sugar tends to be a little higher than normal. This is called "insulin resistance".
- Conditions
- Insulin Resistance, Diabetes, Obesity
- Trial name
- TUDCA/PBA (NCT00771901)
- Testing
- tauroursodeoxycholic acid, sodium phenylbutyrate
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine