Clinical trials: Endoscopic Surgical Procedure
Surgery, Gynecologic Disease
Study Evaluating the Success Rate of Outpatient Management of the Total Benign Hysterectomy by Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) Compared to Each of the Two Laparoscopic Routes (Conventional and Robot-assisted).
Benign total hysterectomy is one of the most commonly performed gynecological surgery. Conventionally performed by a classical surgical approach, it is now provided routinely and for several years by laparoscopy and more recently…
- Trial name
- HYSTERAMBU (NCT06471049)
- Testing
- Benign Hysterectomy
- Where
- France
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Elsan
Rhinosinusitis Chronic, Bleeding
This Study Aims to Assess the Impact of 50°C Saline Irrigation on the Overall Intraoperative Blood Loss and Surgical Visualization During Endoscopic Sinus Surgery for Rhinosinusitis.
Objectives: Intraoperative bleeding during endoscopic sinus surgery for severe rhinosinusitis may significantly compromise the surgical field.
- Trial name
- NCT07627789
- Testing
- Hot saline irrigation, Room-temperature saline irrigation
- Where
- Poland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Military Institute of Aviation Medicine
Hyperglycemia, Postoperative Infection
Hyperglycemia in Neurosurgery
Poor glycemic control is recognized as a risk factor for postoperative infection. For the neurosurgical patient, postoperative infection can lead to devastating complications such as meningitis, encephalitis and death.
- Trial name
- NCT05236751
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Colon Malignant Tumor, Colon Benign Tumor
Apollo Overstitch, a Treat and Resect Model
The Overstitch (Apollo Endosurgery, Austin, Texas) is an FDA cleared product which attaches to a standard double channel endoscope.
- Trial name
- Overstitch (NCT01307813)
- Testing
- Overstitch Endoscopic Suturing System
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Endoscopic Surgical Procedure
Percutaneous Sigmoid Fixation For Management Of Recurrent Sigmoid Volvulus
The investigators included all patients who were presented to emergency department with recurrent sigmoid volvulus at Zagazig University hospital between (August 2024 to August 2025).
- Trial name
- NCT07155304
- Testing
- percutaneous sigmoid colon fixation
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Thirst; Due to Deprivation of Water, Patient Satisfaction
Early Oral Hydration in Relieving Postoperative Thirst
This study aims to evaluate whether allowing early oral hydration on demand effectively relieves postoperative thirst and enhances patient satisfaction in individuals undergoing urological endoscopic procedures
- Trial name
- NCT07563530
- Testing
- Early oral hydration, No early oral hydration (As per Standard PACU Protocol)
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Orbital Floor Fracture
Efficacy of Endoscopic Transantral Surgical Approach in the Repair of Orbital Blow-Out Fractures
Aim of this study is to assess the efficacy of endoscopic trans-maxillary surgical approach versus traditional trans-orbital surgical approach (control group) in orbital blow out fractures in terms of postoperative clinical and…
- Trial name
- NCT03011047
- Testing
- endoscopic trans-antral approach, trans-orbital surgical approach
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Nahla Mahmoud Awad
Motion Sickness, Postoperative Nausea and Vomiting
Gynecologic Endoscopic Surgery of Female Motion Sickness Patients
The goal of this clinical trial is to compare the analgesic effect of sufentanil and ibuprofen and the incidence of vomiting, and to choose better postoperative analgesic drugs for motion sickness patients.in describe participant…
- Conditions
- Motion Sickness, Postoperative Nausea and Vomiting, Ibuprofen
- Trial name
- NCT06232785
- Testing
- Ibuprofen, sufentanil
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Jilin University
Natural Orifice Endoscopic Surgery, Disease, Adnexal
Notes Adnexectomy for Benign Pathology Compared to Laparoscopic Excision
Objective: To compare vNOTES (vaginal Natural Orifice Transluminal Endoscopic Surgery) and established laparoscopic removal of benign adnexal masses Study design: Randomized controlled/single…
- Conditions
- Natural Orifice Endoscopic Surgery, Disease, Adnexal, Laparoscopic Surgery
- Trial name
- NOTABLE (NCT02630329)
- Testing
- vNOTES adnexectomy, Laparoscopic adnexectomy
- Where
- Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Imelda Hospital, Bonheiden
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Sinus Infection Chronic
Propofol Versus Sevoflurane During FESS
Good surgical conditions are crucial for an optimal surgery result and safe procedure. Minimal blood loss in the surgical field is one of the most important conditions to maintain a good visualization, especially in surgeries…
- Trial name
- NCT04619160
- Testing
- Propofol, Sevoflurane
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Ergonomics, Virtual Reality Headset
Feasibility and Ergonomic Impact of A Virtual Reality Headset in Endoscopic Procedures
The purpose of this study is to assess the feasibility of using a virtual reality headset (VRH) during endoscopy and its impact on the endoscopist ergonomics.
- Conditions
- Ergonomics, Virtual Reality Headset, Virtual Reality, Endoscopy
- Trial name
- NCT07493863
- Testing
- Virtual reality headset, MYSELF checklist
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Blood Loss, Surgical
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS.
- Trial name
- NCT06725732
- Testing
- Tranexamic Acid (TXA), Tranexamic Acid
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Morbid Obesity, Weight Loss
Endoscopic Surgery for Bariatric Revision After Weight Loss Failure
Morbid obesity and its associated metabolic diseases are on the rise in the United States. Currently, the best treatment for obesity is bariatric surgery where both roux-en-Y gastric bypass and sleeve gastrectomy offer…
- Trial name
- NCT01871896
- Testing
- Endoscopic Suturing to Create Early Satiety
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nasal Polyps
Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS
This study aimed to show the effect of sphinopalatine ganglion blockade on surgical field, hemodynamics and postoperative pain in FEES operation.
- Trial name
- NCT04996576
- Testing
- infrazygomatic approach sphinopalatine ganglion block, intranasal injection approach of sphinopalatine ganglion block
- Where
- 2 sites in Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Gastrointestinal Dysmotility
Enteric Neural Precursor Cells (ENPC) in the Human Gut
The study aim is to acquire human tissues to (a) understand the structure and organization of the human Enteric Nervous System; (b) perform a molecular transcriptomic profile of individual cells residing in the human gut; (c)…
- Trial name
- NCT04880538
- Testing
- Endoscopic procedure
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Uterine Diseases
Hysterectomy by Transabdominal Laparoscopy or NOTES
Objective: To randomly compare hysterectomy by vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus laparoscopy uterus in women with benign gynecological pathology.
- Trial name
- HALON (NCT02631837)
- Testing
- vNOTES hysterectomy, LSC hysterectomy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imelda Hospital, Bonheiden
Morbid Obesity, Weight Loss
Endoscopic Gastric Plication for Weight Loss in Morbidly Obese Patients Prior to Incisional Hernia Repair
Incisional hernias occur in nearly 20% of all laparotomy incisions accounting for almost 400,000 ventral hernia repairs annually in the United States.
- Conditions
- Morbid Obesity, Weight Loss, Complex Incisional Hernias
- Trial name
- NCT02078934
- Testing
- Endoscopic Gastric Plication
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Feeding Disorders
Nasal Bridles and Repeat Endoscopic Procedures for Endoscopic Nasoenteric Tubes
In critically ill patients, nutrition is a major part of healing and recovery. In patients unable to tolerate oral feeding, nasoenteric tube feeding (a tube placed from the nose to the stomach or small intestine) provides a safe…
- Trial name
- NCT03966157
- Testing
- Nasal Bridle
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Cholecystolithiasis, Surgery
The Effect of Transvaginal vs. Conventional Laparoscopic Cholecystectomy on the Postoperative Course
Uncomplicated laparoscopic cholecystectomy will in most patients result in moderate to severe pain until the first postoperative day. This will subside during the second and third postoperative day [1].
- Conditions
- Cholecystolithiasis, Surgery, Pain
- Trial name
- TRAVAKOL (NCT01552421)
- Testing
- TV NOTES cholecystectomy
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital