Clinical trials: Endovascular Thrombectomy
Acute Ischemic Stroke
Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke
It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vascular occlusion (LVO) patients with a large infarct core.
- Trial name
- MATCH (NCT06870448)
- Testing
- Methyprednisolone sodium succinate
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Ischemic Stroke
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
The main goal of this study is to find out if a new, quick "brain rescue" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.
- Trial name
- RAPIDIMPROVE (NCT07598799)
- Testing
- High-dose RL-IPostC, Low-dose RL-IPostC
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Acute Lower Limb Arterial Occlusion
The ArtixASCEND Study
This study is a post-market, prospective, multicenter, single-arm study to evaluate the safety and effectiveness of the Artix Thrombectomy System in patients with acute lower extremity arterial occlusions.
- Trial name
- NCT07135895
- Testing
- Artix Thrombectomy System
- Where
- 23 sites in United States
- Volunteers
- 250 people
- Sponsor
- Inari Medical
Stroke, Ischemic, Stroke, Acute
A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)
Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP.
- Trial name
- NCT05230914
- Testing
- Simplified imaging strategy, Standard imaging strategy
- Where
- 8 sites in China
- Volunteers
- 1,846 people
- Sponsor
- Xinqiao Hospital of Chongqing
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion
To assess the effect of intravenous tenecteplase plus endovascular thrombectomy (EVT) compared to EVT alone on 4.5 to 24 hours after stroke due to basilar artery occlusion.
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT05701956
- Testing
- Tenecteplase, Endovascular thrombectomy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Ischemic Stroke
COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke.
This study will develop and validate a novel, active/conductive combined head and neck cooling system to selectively cool the ischemic penumbra during the acute phase of stroke, reducing neuronal damage and improving stroke…
- Trial name
- PEN-Cool (NCT07844096)
- Testing
- PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care
- Where
- 5 sites in India
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Acute Ischemic Stroke, Hypothermia
Safety and Efficacy of Selective Intra-Arterial Cooling Infusion Combined With EVT in Acute Ischemic Stroke
This is a multicenter, randomized, controlled, subject- and assessor-blinded clinical trial. The research objective is to evaluate the safety and efficacy of selective intra-arterial cooling infusion combined with endovascular…
- Trial name
- FOCUS (NCT06485427)
- Testing
- Selective Intra-arterial Cooling Infusion (IA-SCI)
- Where
- 12 sites in China
- Volunteers
- 258 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Acute Ischemic Stroke
A Study to Evaluate the Safety and Efficacy of LT3001 Drug Product in Subjects AIS Undergoing EVT
A phase IIb clinical study to evaluate the safety and efficacy of single or multiple doses of LT3001 drug product in subjects with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).
- Trial name
- NCT05198323
- Testing
- LT3001 Drug Product
- Where
- 2 sites in United States, Taiwan
- Volunteers
- 66 people
- Sponsor
- Lumosa Therapeutics Co., Ltd.
Stroke, Neuroprotection
Regional Hypothermia in Combination With Endovascular Thrombectomy in Acute Ischemic Stroke
The investigators have previous shown that regional hypothermia by the intra-arterial infusion of cold saline combined with mechanical thrombectomy in acute ischemic stroke is feasible and safe.
- Conditions
- Stroke, Neuroprotection, Hypothermia
- Trial name
- RE-HIBER (NCT04554797)
- Testing
- Regional Hypothermia
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Endovascular Thrombectomy
Factors Affecting Clinical and Radiological Outcome in Endovascular Management of Acute Ischemic Stroke Due to Large Vessel Occlusion
Acute ischemic stroke (AIS), particularly if it is caused by a large-vessel occlusion (LVO), is a severe and life-threatening disease.
- Trial name
- FACTOR-LVO (NCT07740018)
- Testing
- endovascular thrombectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Stroke, Ischemic
Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke
Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke is a multi-centers registration. It starts in Jan 2019. The key items in the registration form include basic demographic profiles, past medical history, time…
- Trial name
- TREAT-AIS (NCT05281055)
- Testing
- Endovascular thrombectomy
- Where
- Taiwan
- Volunteers
- 3,000 people
- Sponsor
- National Taiwan University Hospital
Stroke, Acute Ischemic
Endovascular Thrombectomy With and Without Intravenous Thrombolysis in Extended Time Window
The primary hypothesis being tested in this trial is that ischemic stroke patients in large vessel occlusion of anterior circulation at 4.5 - 9 hours post onset of stroke will have improved clinical outcomes when given…
- Trial name
- NCT05634382
- Testing
- Intravenous thrombolysis agents, endovascular thrombectomy
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke
Adjunctive Use of Intra-Arterial TNK and Albumin Following Thrombectomy
The purpose of this study is to investigate the feasibility and efficacy of intra-arterial TNK and albumin for patients with acute ischemic stroke after successful thrombectomy and whether there is a synergistic effect between…
- Trial name
- NCT06113848
- Testing
- Intra-Arterial TNK and Albumin, Intra-Arterial TNK, Intra-Arterial Albumin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke
German Stroke Registry - Endovascular Treatment
The German Stroke Registry (GSR) Endovascular Treatment is an academic, independent, prospective, multicentre, observational registry study.
- Trial name
- GSR-ET (NCT03356392)
- Testing
- telephone call d90
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cerebral Venous Sinus Thrombosis
MENA Regional Endovascular Intervention for Venous Cerebral Venous Sinus Thrombosis
REVIVE-CVST is a multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) trial evaluating whether early endovascular thrombectomy (EVT) combined with standard anticoagulation improves outcomes compared to…
- Trial name
- REVIVE-CVST (NCT07548346)
- Testing
- Endovascular Thrombectomy, Anticoagulation Therapy
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 440 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Ischemic Stroke, Covid19
Acute Revascularization Treatment in Ischemic Stroke Patients With COVID-19
Case-series and cohort studies have shown the feasibility of reperfusion therapies in patients with ischemic stroke and COVID-19, but due to the absence of a contemporary control group of non-COVID-19 patients, small sample size…
- Trial name
- NCT04895462
- Where
- Switzerland
- Volunteers
- 15,128 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Ischemic Stroke
Outcome in Patients Treated with Intraarterial Thrombectomy - OptiMAL Blood Pressure Control (OPTIMAL-BP)
Recent endovascular thrombectomy (EVT) trial have proven the effectiveness of intraarterial revascularization in patients with larger cerebral artery occlusion.
- Trial name
- NCT04205305
- Testing
- conventional blood pressure control (labetalol, nicardipine), intensive blood pressure control (labetalol, nicardipine)
- Where
- South Korea
- Volunteers
- 306 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation
Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as the standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation, Large Vessel Occlusion, Thrombectomy
- Trial name
- NCT07196605
- Testing
- Sodium Sivelestat
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke Acute, Thrombectomy
Thrombectomy Versus Best Medical Management in Large Vessel Occlusion Stroke Patients Presenting Beyond 24 Hours and With Presence of Collateral Flow on CT Angiography
The goal of this clinical trial is to investigate if endovascular treatment (EVT) can effectively treat patients with large vessel occlusion (LVO) who present beyond the typical 24-hour window after symptom onset.
- Conditions
- Stroke Acute, Thrombectomy, Medical Treatment, Large Vessel Occlusion
- Trial name
- NCT06654375
- Testing
- Endovascular Thrombectomy
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke, Intracranial Atherosclerosis ICAS
Effect of Balloon Angioplasty vs Stenting Following Residual Stenosis After Endovascular Treatment of Intracranial Atherosclerotic Acute Ischemic Stroke
The ANGEL-ICAS trial is a multicenter, prospective, randomized, open-label, blinded-endpoint study designed to determine whether rescue balloon angioplasty is noninferior to rescue stenting in patients with intracranial…
- Trial name
- ANGEL-ICAS (NCT07026331)
- Testing
- balloon angioplasty, Stent
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Beijing Anzhen Hospital