Clinical trials: Esophageal Pressure Measurement
Intensive Care, Ventilator Lung
Respiratory Mechanics in Intensive Care Patients
This study aims at assessing the respiratory mechanics of intubated patients in intensive care unit.
- Trial name
- PREMIER (NCT03420417)
- Testing
- Esophageal pressure measurement
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Capnothorax, One Lung Ventilation
During Chest Surgery, One Lung is Isolated From Ventilation to Improve Visibility, With Carbon Dioxide Introduced Between the Lung and Chest Wall (Capnothorax): the Study Seeks to Optimize Ventilation Through Esophageal Pressure Measurement, Reducing Respiratory Complications.
The objective of this single-center observational study is to improve the safety and effectiveness of chest surgery through the use of a new ventilation technique.
- Conditions
- Capnothorax, One Lung Ventilation, Thoracic Surgery, Esophageal Pressure Measurement
- Trial name
- CapnoPes (NCT06837636)
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Cardarelli Hospital
Dysphagia
Standardizing Swallow Pressure Measurements
This study aims to directly compare and contrast swallowing pressure and impedance measurements obtained from two high-resolution manometry (HRM) systems: the Laborie LMT Pharyngeal System and the Medtronic ManoScan ESO HRM…
- Trial name
- NCT07475091
- Testing
- Laborie LMT Pharyngeal System (3.7 mm catheter), Medtronic ManoScan ESO HRM System (4.2 mm catheter)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anesthesia
Influence of Xenon Anaesthesia on Transpulmonary Pressure and Tidal Volume Distribution
The influence of xenon anaesthesia on transpulmonary pressure and tidal volume distribution will be investigated in a prospective cohort study in 10 patients of normal weight and 10 obese patients undergoing routine xenon-based…
- Trial name
- NCT02682758
- Testing
- Xenon
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Esophageal Pressure Measurement
Comparison of Two Tests in the Assessment of the Accuracy of Esophageal Pressure Variations Measurement During Mechanical Ventilation
Esophageal pressure measurement, obtained with the use of an esophageal balloon catheter, is fundamental to assess mechanical characteristics of the respiratory system during mechanical ventilation.
- Trial name
- NCT02036788
- Testing
- Occlusion test, Thoraco-abdominal compressions
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Achalasia, GORD
vMII for Measurement of Oesophageal Bolus Transport and Reflux
Recent work at St. Thomas' has validated an innovative new design of a multichannel intraluminal impedance (MII) catheter that is sensitive to variation in oesophageal volume in healthy volunteers and patients.
- Trial name
- vMII (NCT00604942)
- Testing
- Heller's Myotomy, Nissen Fundoplication, domperidone or esomeprazole (Conservative management)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Upper Esophageal Sphincter Relaxing Pressure
Swallowing Evaluation by HRIM in Patients With Cervical Spondylosis
patients with cervical spondylolysis may have swallowing or eating difficulty. In this study, we will use high resolution impedance manometry to evaluate these patients' detailed swallowing mechanisms.
- Trial name
- NCT05713968
- Testing
- patients with EAT-10 higher than 3 or frailty questionnaire higher than 2 examined by HRIM, patients with EAT-10 lower than 3 or frailty questionnaire lower than 2
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Esophageal and Gastric Varices
Study on Portal Vein Pressure Gradient Measurement Under Endoscopic Ultrasound Guidance for Gastric Fundal Varices
This study aimed to evaluate the feasibility and safety of direct gastric variceal pressure measurement in patients with large spontaneous portosystemic shunts, and to determine whether the gastric variceal pressure gradient…
- Trial name
- NCT07478770
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Surgery
Esophageal Balloon Measurements to Better Characterize Thoraco-abdominal Interrelationship Mechanics.
Esophageal pressure measurements in surgical patients requiring mechanical ventilation during abdominal laparoscopic or robotic surgeries requiring intra-abdominal insufflation.
- Trial name
- NCT03624491
- Testing
- Esophageal pressure measurement guided ventilation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Morbid, Ventilator-Induced Lung Injury
Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon
This is a research study to determine if identifying an optimal level of positive end-expiratory pressure (PEEP) targeted specifically to individualized patient characteristics will shorten the time on the ventilator.
- Conditions
- Obesity, Morbid, Ventilator-Induced Lung Injury, Respiratory Failure
- Trial name
- PROP OPEN (NCT03951064)
- Testing
- Esophageal balloon, Intervention Spontaneous Breathing Trial (SBT) and Extubation, Control Spontaneous Breathing Trial and Extubation
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of North Carolina, Chapel Hill
Cardiac Surgery, CABG
Measurement of MSFP and Stressed Volume With CardioQ+®
To study the reliablity of MSFP and stressed volume to follow volume loading and to predict fload loading responsiveness in patients after elective coronary artery bypass grafting (CABG) surgery.
- Trial name
- NCT03139929
- Testing
- MSFP
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Lung Injury, Acute Respiratory Distress Syndrome
Mechanical Ventilation, Directed by Esophageal Pressure Measurements, in Patients With Acute Lung Injury
The purpose of this study is to see whether esophageal pressure (PES) measurements will allow the investigators to choose the best method of mechanical ventilation in patients with acute lung injury (ALI).
- Trial name
- NCT00127491
- Testing
- Placement of an esophageal balloon measurements, Low tidal volume ventilation, Transpulmonary pressure-directed ventilation (EPVent)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Beth Israel Deaconess Medical Center
Severe Acute Respiratory Distress Syndrome / Severe ARDS, Invasive Mechanical Ventilation
Hemodynamic and Cardiac Effects of Individualized PEEP Titration Using Esophageal Pressure Measurements in ARDS Patients
The acute respiratory distress syndrome (ARDS) is common condition in critical ill patients affecting 7.2 people / 100,000 population / year and more than 7% of patients with invasive mechanical ventilation for more than 24…
- Conditions
- Severe Acute Respiratory Distress Syndrome / Severe ARDS, Invasive Mechanical Ventilation, Individualized PEEP Treatment Strategy
- Trial name
- ENCODE (NCT02617914)
- Testing
- individualized PEEP treatment, Invasive mechanical ventilation, ECMO,
- Sponsor
- RWTH Aachen University
ARDS
PEEP Guided by Esophageal Balloon Measurement and Its Effect on Recruitment Maneuver
The aim of the study is to examine the effects of two different levels of PEEP on subsequent standard recruitment maneuver.
- Trial name
- NCT01737190
- Testing
- PEEP guided by Esophageal pressure + Recruitment maneuver
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Wolfson Medical Center
Positive-Pressure Respiration/Methods, Esophagus/Physiopathology
Intraoperative PEEP Setting During Laparoscopic Gynecologic Surgery
The creation of pneumoperitoneum during laparoscopic surgery can have significant effects on the respiratory system including decreased respiratory system compliance, decreased vital capacity and functional residual capacity and…
- Conditions
- Positive-Pressure Respiration/Methods, Esophagus/Physiopathology, Pleura/Physiopathology, Gynecologic Surgical Procedures
- Trial name
- NCT03256396
- Testing
- PEEP setting based on esophageal pressure measured
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Mahidol University
ARDS (Acute Respiratory Distress Syndrome)
Influence of Lung Recruitment Potential on Positive End-Expiratory Pressure (PEEP) Titration Strategies in Acute Respiratory Distress Syndrome (ARDS) Patients.
Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia and diffuse alveolar collapse, often requiring invasive mechanical ventilation.
- Trial name
- RECRUIT-PEEP (NCT07603310)
- Testing
- Positive End-Expiratory Pressure (PEEP) Titration guided by Static Compliance, Positive End-Expiratory Pressure (PEEP) Titration guided by Transpulmonary Pressure
- Where
- Chile
- Volunteers
- 52 people
- Sponsor
- Hospital Dr. Franco Ravera Zunino
Stroke, Dysphagia
Effects of CTAR and a Swallowing Pressure Ball in Older Stroke Adults
This study aims to investigate the effectiveness of resistance swallowing rehabilitation using Chin Tuck Against Resistance (CTAR) exercises combined with an innovative swallowing pressure ball in improving swallowing function…
- Conditions
- Stroke, Dysphagia, Post-Stroke Dysphagia
- Trial name
- NCT07620210
- Testing
- Innovative Swallowing Pressure Measurement Ball Combined With CTAR Training, Conventional Swallowing Rehabilitation
- Where
- Taiwan
- Volunteers
- 132 people
- Sponsor
- Chimei Medical Center
Surgery, One-lung Ventilation
Esophageal Pressure Measurements During One-lung Ventilation
The investigators will assess the feasibility and validity of esophageal pressure measurements during one-lung ventilation in the lateral position for surgery by comparing to lung collapse estimated from electrical impedance…
- Trial name
- NCT04725318
- Testing
- One-lung ventilation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Fluid Responsiveness
Accuracy of Pulse Pressure Variation and of Pleth Variability Index to Predict the Response to a Fluid Challenge
The aim of this study is to compare the accuracy of Pleth Variability Index (Radical 7 device) and of Pulse Pressure Variation (Nexfin device) with the Doppler measurement of stroke volume (esophageal Doppler) to detect the…
- Trial name
- Nexfin2 (NCT02040948)
- Testing
- - Nexfin (Pulse Pressure Variation) - Radical 7 (Pleth Variability Index) - CardioQ (stroke volume)
- Where
- 2 sites in France
- Volunteers
- 68 people
- Sponsor
- Hopital Foch
Morbid Obesity, Respiratory Failure
Comparison of Esophageal Manometry and CT Scan Measurements
The goal of this study is to determine the relationship between esophageal pressure (Pes) and superimposed pressure (SP) in subjects with morbid obesity.
- Trial name
- NCT04213911
- Testing
- low-dose chest CT scan, insertion of esophageal balloon
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital