Clinical trials: Esophageal Strictures
Dysphagia, Dysphonia
Dysphagia and Dysphonia Outcomes in SARS CoV-2 (COVID-19) Infection (DYADS Study)
This study examines the presence, severity and natural history of dysphagia and dysphonia in the post-extubation and severely unwell COVID-19 patient.
- Conditions
- Dysphagia, Dysphonia, Subglottic Stenosis, Voice Disorders
- Trial name
- DYADS (NCT04584658)
- Testing
- Fibreoptic Endoscopic Evaluation of Swallowing (FEES), Videofluoroscopy, Dysphagia Handicap Index (DHI)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Dysphagia, Aspiration
PEG by Introducer Method Via EG Scan
Percutaneous endoscopic gastrostomy(PEG) by introducer method has been proven to be safe and easy to perform. However, it is limited by its need to be performed in an endoscopy unit. E.G.
- Conditions
- Dysphagia, Aspiration, Esophageal Stenosis
- Trial name
- NCT02183207
- Testing
- Percutaneous Endoscopic Gastrostomy
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- The Catholic University of Korea
Esophageal Stenosis Acquired
Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Large Esophageal Carcinoma
Endoscopic submucosal dissection as the fastest growing endoscopic treatment technology in the past decade has been widely used in the treatment of early esophageal cancer and gastric cancer without local lymph node metastasis.
- Trial name
- NCT03165344
- Testing
- Hydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration), Triamcinolone Acetonide (route of administration), Prednisone (route of administration)
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University Third Hospital
Pulmonary Regurgitation, Pulmonary Insufficiency
Pulmonic Valve REplacement Multi-discIpline EMEA Registry
The purpose of this registry is to retrospectively and prospectively obtain clinical data in consecutively treated patients, in order to demonstrate that the commercially available Edwards SAPIEN Valve with the RF3 delivery…
- Conditions
- Pulmonary Regurgitation, Pulmonary Insufficiency, Pulmonary Stenosis
- Trial name
- PREMIER (NCT01356108)
- Testing
- Transcatheter Pulmonic Valve Replacement (TPVR) (Edwards SAPIEN™ THV)
- Where
- 16 sites in Belgium, Germany and 7 more
- Volunteers
- 127 people
- Sponsor
- Edwards Lifesciences
Head and Neck Neoplasm, Gastrostomy
Endoscopic Direct-PEG Placement in Patients Unable to Undergo Pull-PEG Procedure
Placement of a feeding tube through a gastrostomy can be performed endoscopically or radiologically. While percutaneous endoscopic gastrostomy (PEG) tube placement is most frequently performed using a "pull" technique, this…
- Conditions
- Head and Neck Neoplasm, Gastrostomy, Esophageal Stenosis and Obstruction
- Trial name
- PEG (NCT04151030)
- Testing
- PEG placement
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Kansas City Veteran Affairs Medical Center
Esophageal Stenosis
Esophageal Replacement With a Decellularized Human Esophagus Graft
The aim of the study is to analyze over a 12 month-period, the safety and the efficacy of a circumferentiel oesophageal replacement of the esophagus by a decelularized human esophagus, in 24 patient with a short esophageal…
- Trial name
- ESOGRAFT (NCT06662370)
- Testing
- Replacement of the esophagus with a decellularized human esophagus graft
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Recessive Dystrophic Epidermolysis Bullosa, Dysphagia
Treatment of Dysphagia in Patients With Dystrophic Epidermolysis Bullosa With Budesonide: a Retrospective Bicentric Study Nice - Paris St Louis / Necker (EBUDE Study)
Budesonide is an anti-inflammatory medication that works by decreasing the immune system's overreaction. In the treatment of eosinophilic esophagitis, especially with Jorveza or a preparation made in a pharmacy, it reduces the…
- Conditions
- Recessive Dystrophic Epidermolysis Bullosa, Dysphagia, Esophageal Stenosis
- Trial name
- EBUDE (NCT07684105)
- Testing
- The retrospective data collected will be entered into an eCRF and then analyzed centrally
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Esophageal Stricture
Steroid Versus Mitomycin-C Use in Pediatric Benign Recurrent Esophageal Stricture
To compare the efficacy of steroid injection versus topical mitomycin-C in the treatment of pediatric benign recurrent esophageal strictures.
- Trial name
- NCT06626802
- Testing
- Balloon Dilation + Topical Mitomycin, Balloon Dilation + Injection Triamcinolone
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- King Edward Medical University
Tracheoesophageal Fistula, Esophageal Atresia
Phenotypic and Genetic Assessment of Tracheal and Esophageal Birth Defects in Patients
The investigators propose a preliminary study performing exome sequencing on samples from patients and their biologically related family members with tracheal and esophageal birth defects (TED).
- Conditions
- Tracheoesophageal Fistula, Esophageal Atresia, Laryngeal Cleft, Tracheal Stenosis
- Trial name
- TED (NCT03455881)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Esophageal Stricture
Mitomycin-C Injection Therapy in Refractory Esophageal Stricture
Intralesional Mitomycin-C (MMC) injection has recently been introduced to resolve refractory benign esophageal stricture mostly in children.
- Trial name
- NCT04284826
- Testing
- Endoscopic injection of Mitomycin-C on bougie-dilated refractory benign esophageal stricture
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Ajou University School of Medicine
Esophageal Neoplasms, Constriction
Endoscopic Evaluation After Esophagectomy
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures.
- Conditions
- Esophageal Neoplasms, Constriction, Anastomotic Leak, Ischemia
- Trial name
- NCT02703142
- Testing
- Patients after esophagectomy
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Nagasaki University
Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus
Azygos Vein Preservation; Its Impact on Early Outcomes After Neonatal EA/TOF Repair
Azygos vein preservation revisited: impact on early outcomes after repair of Esophageal atresia/ Tracheo-Esophageal Fistula in newborns. A randomized controlled study.
- Conditions
- Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus, Leak, Anastomotic, Stricture Esophagus
- Trial name
- EArAzygousvp (NCT05957562)
- Testing
- EA/TOF primary repair with Azygos vein preservation, EA/TOF primary repair with Azygos vein sacrifice (disconnection)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Esophageal Stenosis
Intralesional Steroid Injection Versus Oral Prednisolone in Prevention of Esophageal Stricture
Endoscopic resection of superficial esophageal neoplasms is already a reality and presents important advantages when compared to esophagectomy as fewer complications and better quality of life.
- Trial name
- NCT04498260
- Testing
- Local steroid - triamcinolone acetonide, Oral steroid - predonisolone
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Stent Migration
Preventing Esophageal Stent Migration in Esophageal Strictures
This study aims to assess the efficacy and rate of stent migration in standard of care esophageal stents that are not fixed, compared to those that are fixed with either standard of care OTSC stentfix or standard of care stent…
- Trial name
- NCT05081752
- Testing
- OTSC Stentfix, Stent Suturing / Endoscopic Clips
- Where
- United States
- Sponsor
- NYU Langone Health
Esophageal Stent Fixation
Comparison of Stent Suturing Versus OTSC Stentfix
The purpose of this study is to investigate whether OTSC stentfix is a feasible, safe, and efficient device that can be used for esophageal stent fixation (to prevent stent migration) in patients with benign, non-stricture…
- Trial name
- NCT04936425
- Testing
- OTSC Stentfix
- Where
- United States
- Sponsor
- NYU Langone Health
Constriction, Pathological
Fully Coated, Removable, Self-expanding Oesophageal Stents for Preventing Strictures Following Complete Barretts Excision.
The purpose of this study is to investigate whether preventative placement of a removable oesophageal stent reduces the rate of scar tissue, or stricture formation after removing the precancerous or early cancerous Barrett's…
- Trial name
- CBE-001-SEOS (NCT01554280)
- Testing
- Fully coated, removable , self-expanding oesophageal stent
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- Professor Michael Bourke
Esophageal Stricture
Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus
To evaluate the safety and efficacy of the ProTractX3™ DCB for the treatment of benign esophageal strictures.
- Trial name
- PATENT-E (NCT05561114)
- Testing
- GIE Medical ProTractX3 TTS DCB, Control
- Where
- 34 sites in United States
- Volunteers
- 198 people
- Sponsor
- GIE Medical
Esophageal Stricture
Prospective Evaluation of Budesonide for Prevention of Esophageal Strictures After Endotherapy
Surgery has been historically the mainstay treatment for advanced pre-malignant lesions and early esophageal cancers. However, esophagectomy is associated with significant morbidity and mortality.
- Trial name
- NCT02069847
- Testing
- Budesonide
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Valvular Heart Diseases, Valvular Heart Disease Stenosis and Regurgitation
ECG and CXR for Predicting Cardiovascular Diseases
This retrospective multicenter cohort study aims to develop and validate an artificial intelligence model integrating electrocardiography (ECG) and chest radiography (CXR) to predict future progression of regurgitant valvular…
- Conditions
- Valvular Heart Diseases, Valvular Heart Disease Stenosis and Regurgitation, Regurgitation, Aortic Valve, Regurgitation, Mitral
- Trial name
- NCT07573852
- Where
- China
- Volunteers
- 116,380 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Degeneration Spine, Cervical Radiculopathy
Salt Water Gargling on Swallowing Following ACDF
The goal of this randomized control trial is to collect sufficient preliminary data on the efficacy of sodium chloride, hereafter referred to as "saltwater" or "saline" in reducing the difficulty of swallowing following…
- Conditions
- Degeneration Spine, Cervical Radiculopathy, Cervical Stenosis, Cervical Spondylosis
- Trial name
- NCT06475365
- Testing
- Sodium chloride gargle
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California