Clinical trials: Exercise Adaptation
HMG-CoA Reductase Inhibitor Toxicity
Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise).
- Trial name
- NCT04636138
- Testing
- Exercise
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Temperature Change, Body
The Validity of CORE Sensor in Heat Training for Male and Female Endurance Athletes
This study is investigating the efficacy of CORE™ devices in calculating core body temperature in athletes under varying environmental conditions.
- Trial name
- CORE (NCT05692947)
- Testing
- Core body temperature device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Aging, Mobility Limitation
Evaluating Implementation and Impact of the Adapted Choose to Move (CTM) Program
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada.
- Conditions
- Aging, Mobility Limitation, Physical Inactivity, Sedentary Behavior
- Trial name
- CTM (NCT06252259)
- Testing
- Choose to Move
- Where
- Canada
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Muscle Hypotrophy, Exercise Performance
Resistance Training Adaptations and Caffeine Intake
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive…
- Conditions
- Muscle Hypotrophy, Exercise Performance, Muscle Strength, Adaptation
- Trial name
- NCT07410195
- Testing
- Caffeine (Constant Daily Dose), Caffeine (Escalating Dose), Caffeine (Training Days Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Muscle Strength, Athletic Performance
Nordic vs Blood Flow Restriction Nordic Exercise in Elite Female Pole Vaulters
The purpose of this randomized controlled trial is to compare the effects of Nordic Hamstring Exercise (NHE) and Blood Flow Restriction-assisted Nordic Hamstring Exercise (BFR-NHE) on hamstring muscle strength, muscle morphology…
- Conditions
- Muscle Strength, Athletic Performance, Hamstring Adaptation, Sports Injury Prevention
- Trial name
- NCT07705698
- Testing
- Nordic Hamstring Exercise, Blood Flow Restriction-Assisted Nordic Hamstring Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Toros University
Depression, Anxiety
Progressive Muscle Relaxation in Nursing Students: Effects on Psychological and Biopsychosocial Outcomes
This randomised controlled trial aims to investigate the effects of progressive muscle relaxation exercises (PMRE) on depression, anxiety, stress, future-oriented attitudes, and biopsychosocial responses in nursing students.
- Conditions
- Depression, Anxiety, Stress, Psychological, Mental Health
- Trial name
- PRMNURSE (NCT07038109)
- Testing
- Progressive relaxation exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Type 2 Diabetes Mellitus
ET-blockade and Exercise-induced Vascular Adaptations in T2DM
The purpose of this study is to establish the effect of ET blockade on vascular adaptations during an 8-week exercise program in subjects with T2DM.
- Trial name
- NCT01779609
- Testing
- Bosentan, Exercise
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Passive Video Games (PVG), Active Video Games (AVG)
Nutritional Adaptations to Physical or Sedentary Activities in Youth
Sedentary behaviors have been shown to increase food consumption among youth and adults. The recent active video games devices have been suggested to compensate for the increased energy intake they induce by the increased energy…
- Conditions
- Passive Video Games (PVG), Active Video Games (AVG), Exercise (EX)
- Trial name
- NCT01912300
- Testing
- experimental condition: Passvice Video game; Avtive Video game; Exercise
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Université Blaise Pascal, Clermont-Ferrand
Cardiovascular Disease
Effect of ACE Genotype on Cardiovascular Rehabilitation
The study aims to systematically investigate the interaction between training modality, ACE genotype and disease in heart patients whom complete a cardiovascular rehabilitation program.
- Trial name
- ACE-REHAB (NCT02845063)
- Testing
- concentric cardiovascular training, eccentric cardiovascular training, ACE genotyping
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Blood Flow Restriction Training, Muscle Oxygenation
"How Blood Flow Restriction Exercise Affects Muscle Oxygenation and Lactate in Elite Athletes"
This study investigates the effects of blood flow restriction (BFR) training combined with low-intensity aerobic exercise on muscle oxygenation, total hemoglobin (THb), and blood lactate levels in elite athletes, comparing them…
- Conditions
- Blood Flow Restriction Training, Muscle Oxygenation, Physiological Adaptations
- Trial name
- NCT06918314
- Testing
- Blood Flow Restriction Kaatsu Training Device
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Hypoxia
Effect of Hypoxic Exposure on Blood Variables in Elite Wrestlers
Twelve male wrestlers of the National Polish Team were observed in the study during the camp. The hypoxia group (n=6) participated in sports training and hypoxic exposure, while the control group (n=6) included wrestlers…
- Trial name
- NCT06373562
- Testing
- hypoxia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Physical Inactivity
High-Intensity Interval Training and Monocyte Epigenetic Adaptation After Detraining
This randomized, work-matched training-detraining-rechallenge study evaluated whether repeated high-intensity interval training produces persistent functional and epigenetic adaptations in human monocytes.
- Trial name
- NCT07771075
- Testing
- High-Intensity Interval Training, Moderate-Intensity Continuous Training
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saif Rasheed Ghanim
Cricket Protein, Whey Protein
Insect vs Animal Protein for Building Muscle
This research is being carried out to investigate the potential of insects (crickets) as a sustainable protein source for supporting human muscle tissue by comparing cricket protein to a commonly used animal protein (whey).
- Trial name
- GAINZ (NCT07159919)
- Testing
- protein supplement
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Stiffness, Aortic, Cardiac Remodeling, Ventricular
Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)
Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a…
- Conditions
- Stiffness, Aortic, Cardiac Remodeling, Ventricular, Vascular Remodeling, Magnetic Resonance Imaging, Functional
- Trial name
- CoATri (NCT03356301)
- Testing
- Cardiac MRI, Applanation tonometry
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Sarcopenia, Osteoporosis
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
- Conditions
- Sarcopenia, Osteoporosis, Aging
- Trial name
- NCT01083901
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Exercise, Bone Resorption
Enhancing Skeletal Adaptations to PTH and Exercise
Exercise is essential for building and maintaining bone mass and strength, but current exercise recommendations for how to achieve this lack detail on the optimal exercise prescription.
- Conditions
- Exercise, Bone Resorption, Bone Formation
- Trial name
- ESkAPE (NCT05029128)
- Testing
- Endurance exercise intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Healthy Participants, Nutrition
Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults
The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women.
- Conditions
- Healthy Participants, Nutrition, Exercise Training
- Trial name
- NCT06372080
- Testing
- Resistance training with hydrolyzed collagen ingestion in healthy young men, Resistance training with hydrolyzed collagen ingestion in healthy young women
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Postexercise Hypotension
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is investigating the role of histamine in generating adaptation to exercise
- Trial name
- NCT05206227
- Testing
- Aerobic Exercise, alpha-FMH, Resistance and Aerobic Exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Healthy Participants
The UBC Long-distance Triathlon Adaptation Study
The purpose of this study is to investigate the effect of 12-months of individualized endurance-training (swimming, cycling and running) on physiological and psychological adaptations in exercise naïve individuals.
- Trial name
- ULTRA (NCT06467656)
- Testing
- Individualized, periodized endurance training for ultra-endurance triathlon., Time-Aligned Control
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Exercise
Protein Supplementation and Endurance Exercise Adaptations
Participants will perform three endurance training sessions weekly for 12 weeks. All participants will be randomly assigned to the protein supplementation group or the placebo (iso-caloric carbohydrate) group.
- Trial name
- NCT03462381
- Testing
- Protein
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wageningen University