Clinical trials: Exercise-Induced Neuromuscular Fatigue
Biological Maturation
Biological Maturation and Plyometric Exercise
Plyometric training comprises one of the most widely used training methods in both individual and team sports, and is widely used by coaches as one of the main training in both adults, and children.
- Trial name
- BiMaPlEx (NCT05442593)
- Testing
- Plyometric training
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Analysis of Post-exertional Malaise Using a Two-day CPET in People With ME/CFS
This study aims to collect and identify key outcome measures or disease parameters in ME/CFS that are altered during elevated symptoms relative to baseline by gathering information before and after symptom provocation using a…
- Trial name
- NCT04026425
- Testing
- Two-day cardiopulmonary exercise test
- Where
- 3 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ithaca College
Statin Intolerance
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity
The purpose of this study is to gain insight into the side-effects of statin consumption, and assess the ability of epicatechin (a compound in dark chocolate) to counteract or reverse these changes.
- Trial name
- NCT02490527
- Testing
- Pure epicatechin capsules (50mg), Simvastatin (40mg)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Chronic Fatigue Syndrome
Exertional Exhaustion in Chronic Fatigue Syndrome
Post-exertional malaise was modeled by having Chronic Fatigue Syndrome (CFS) and sedentary control subjects perform submaximal exercise on 2 consecutive days with objective changes in brain function measured by magnetic resonance…
- Trial name
- NCT03567811
- Testing
- Submaximal bicycle exercise stress test on Days 1 and 2
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Georgetown University
LONG-COVID, Post-acute Sequelae of COVID-19
Skeletal Muscle in PASC and ME/CFS Patients
Rationale: A common feature in patients with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) and Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are skeletal muscle-related symptoms, such as muscle pain, weakness…
- Conditions
- LONG-COVID, Post-acute Sequelae of COVID-19, ME/CFS
- Trial name
- NCT05225688
- Testing
- Bike exertion test
- Where
- Netherlands
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Fatigue Syndrome, Chronic
Epigenetics of Post-exertional Malaise in Patients With ME/CFS
Exploring epigenetic mechanisms of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) is crucial to understand the mechanisms underlying its pathophysiology.
- Trial name
- EPIME (NCT04378634)
- Testing
- Exercise, Mental Stress Test
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Cardiovascular Analysis of PEM
The purpose of this study is to examine cardiopulmonary function in Chronic Fatigue Syndrome (CFS) patients and determine how it relates to the common symptom of Post-exertional malaise (PEM).
- Trial name
- NCT04740736
- Testing
- Saline Infusion
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Neuromuscular Fatigue, Load-velocity Variables
Sensitivity of Load-Velocity Measures for Detecting Fatigue During Smith-Machine Squats
The purpose of this study is to determine whether load-velocity (L-V) relationship variables (L0, v0, and Aline) are sensitive indicators of fatigue produced by different squat fatigue protocols.
- Trial name
- SLV (NCT07307963)
- Testing
- Control Protocol (No Training), Moderate-fatigue, High-fatigue
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
Muscle Damage
Recovery Kinetics Following Eccentric Exercise
The aim of this study will be to investigate the recovery kinetics of neuromuscular fatigue, muscle microtrauma indicators, performance and oxidative stress factors after three different exercise induced muscle damage (EIMD)…
- Trial name
- NCT04733911
- Testing
- 75 eccentric contractions, 150 eccentric contractions, 300 eccentric contractions
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Conditions or Focus of Study, Exercise-Induced Fatigue
Effects of Astaxanthin Supplementation on Soccer Performance Under Fatigue
This study aims to investigate the effects of four-week astaxanthin supplementation on soccer-specific performance under fatigue in soccer players.
- Conditions
- Conditions or Focus of Study, Exercise-Induced Fatigue, Soccer Performance
- Trial name
- AX-FATIGUE (NCT07509970)
- Testing
- Astaxanthin
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Cardiopulmonary Testing in ME/CFS to Improve Diagnostic Accuracy
Circumstantial evidence suggests that patients diagnosed with myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) perform worse on day 2 in a 2-day consecutive cardiopulmonary exercise test (CPET).
- Trial name
- NCT02970240
- Testing
- Cardiopulmonary testing
- Where
- Norway
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Exercise-Induced Fatigue
Muscle Oxygenation and Autonomic Recovery After Repeated Sprint in Competitive Soccer Players
This study evaluates the acute and short-term recovery responses to repeated sprint exercise in competitive male soccer players.
- Trial name
- NCT07742163
- Testing
- 8 x 30 m Repeated Sprint Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Exercise-Induced Fatigue, Football Performance
Effects of Hydrogen-rich Water Consumption on Transient Fatigue During an Official Football Match.
The purpose of this study is to determine whether drinking hydrogen-rich water can reduce fatigue and help football players maintain high-intensity physical activity during an official football match.
- Trial name
- HRW-FOOTBALL (NCT07855120)
- Testing
- Hydrogen-Rich Water (HRW)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Palacky University
Physiological Tremor, Exercise-Induced Neuromuscular Fatigue
Effect of Trigger Point Cryostimulation on Exercise-Induced Tremor in Adolescent Swimmers
This study examines whether local cryostimulation of myofascial trigger points can reduce physiological tremor that occurs after intense physical exercise.
- Trial name
- NCT07480200
- Testing
- Cryostimulation of Myofascial Trigger Points
- Where
- Poland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
PEM, a Starting Point to Investigate ME/CFS
Exercise is an important contributor to general health and is considered a potential remedy for chronic diseases. This is in strong contrast with the observation that in most myalgic encephalomyelitis (ME/CFS) patients exercise…
- Trial name
- PEM_CFS (NCT07715838)
- Testing
- No intervention is planned
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen