Clinical trials: Experimental
Hiv
Exploring a Digital HIV Onward Disclosure Intervention, in People Living With HIV of Sub-Saharan African Ethnicity.
Research has shown that people living with HIV struggle to disclose their HIV status to others, (a process known as self-disclosure or onward disclosure) due to associated challenges, including fear of discrimination from others.
- Trial name
- NCT05804968
- Testing
- Digital HIV Self Disclosure Intervention
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Royal Holloway University
HIV Infections
Safety of and Immune Response to the Experimental Preventive HIV Vaccine, EP HIV-1090, in Healthy, HIV-1 Uninfected Adults
The purpose of the study is to determine the safety of and immune response to the investigational HIV vaccine, EP HIV-1090, in HIV uninfected adults.
- Trial name
- NCT00141024
- Testing
- EP HIV-1043, EP HIV-1090
- Where
- 3 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza Prevention, Seasonal Influenza
Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS0116-00-VP (FluMos-v2) With and Without ALFQ Adjuvant in Healthy Adults
Background: Vaccines help the body learn to fight infections. Some vaccines are combined with adjuvants, which are added substances that make vaccines work better.
- Trial name
- NCT06863142
- Testing
- VRC-FLUMOS0116-00-VP, ALFQ
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Bacterial
Trial to Evaluate Safety and Immune Response of an Investigational Pneumococcal Vaccine in Adults Aged 50 To 64 Years
This study will evaluate the safety and immune response of a new formulation of pneumococcal vaccine, PnMAPS30plus, in healthy adults aged 50 to 64 years.
- Trial name
- NCT07428759
- Testing
- Pn-MAPS30plus, PCV20
- Where
- 2 sites in Australia
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Disease
Team-Based Delivery of Care in Outpatient Settings
Through this research we intend to evaluate whether a team-based care delivery approach using daily huddles is effective in improving caregiver and patient outcomes in primary care setting.
- Trial name
- NCT03062670
- Testing
- Retreat
- Where
- 10 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Stress
Outcomes of a Small Process Group on Medical Students' Grit, Resilience, and Stress
The incidence of burnout and mental ill-health begins very early in medical school and continues to be high throughout training.
- Trial name
- NCT06003920
- Testing
- Process group
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Western University of Health Sciences
Airway Obstruction, Dyspnea
Heliox in Experimental Upper Airway Obstruction
Currently it is common medical wisdom that HELIOX (mixture of Helium in Oxygen) with a fraction of Helium below 60% is not effective in reducing airway obstruction.
- Trial name
- NCT00788788
- Testing
- HELIOX
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Dental Erosion, Acid Wear
Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion
The purpose of this study is to compare and evaluate the ability of two European Union (EU) regulated gel to foam toothpaste formulations versus a non-fluoride toothpaste using a modified in-situ model of dental erosion and…
- Trial name
- NCT01657903
- Testing
- Sodium Fluoride, Potassium nitrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pneumonia, Bacterial
A Trial to Evaluate the Safety and Immune Response of an Investigational Pneumococcal Vaccine in Adults 50 To 64 Years of Age
This clinical study is designed to evaluate an investigational pneumococcal vaccine named Pn-MAPS30plus. The vaccine is designed to stimulate the immune system to produce antibodies against various serotypes of the S.
- Trial name
- NCT07105722
- Testing
- Pn-MAPS30plus, PCV20
- Where
- 4 sites in Australia
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Colonic Neoplasms, Rectal Neoplasms
Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Indications for colostomy are rectal or anal cancer, diverticular disease, radiation enteritis, complex perirectal fistulas, anorectal trauma, severe incontinence, motility and functional disorders.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Fecal Incontinence
- Trial name
- EACC (NCT02308631)
- Testing
- ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Gender-Based Violence, Intimate Partner Violence
GBV Response Training for Health Assistant Students in Nepal
This study evaluated a six-day Gender-Based Violence (GBV) response training for PCL General Medicine (Health Assistant) students in Nepal.
- Conditions
- Gender-Based Violence, Intimate Partner Violence, Health Professions Education
- Trial name
- GBV-HA-RT (NCT07851883)
- Testing
- Six-Day GBV Response Training (WHO LIVES-based)
- Where
- Nepal
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Axon Infotech Research Academy Pvt. Ltd.
Healthy
Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Experimental Increase of Intraocular Pressure in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00914394
- Testing
- NG-monomethyl-L-arginine (L-NMMA), Phenylephrine, Laser Doppler Flowmetry
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Nutrition, Food Purchasing Intention
Taxation Online Experimental Supermarket
Scientific context The increase in the consumption of unhealthy food coupled with a suboptimal consumption of healthier options have increased the risk of non-communicable diseases (NCD) worldwide.
- Trial name
- SUPERNET 2 (NCT07593937)
- Testing
- Taxation, Subsidies
- Where
- France
- Volunteers
- 2,239 people, healthy volunteers welcome
- Sponsor
- University of Paris 13
Respiratory Syncytial Virus Infections
Efficacy Study of GSK's Investigational Respiratory Syncytial Virus (RSV) Vaccine in Adults Aged 60 Years and Above
This study will evaluate the efficacy of the RSVPreF3 OA investigational vaccine in preventing Lower Respiratory Tract Disease (LRTD) caused by RSV in adults ≥60 years of age following a single dose of the RSVPreF3 OA vaccine and…
- Trial name
- NCT04886596
- Testing
- RSVPreF3 OA vaccine
- Where
- 277 sites in United States, Australia and 15 more
- Volunteers
- 26,675 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Overweight, Obesity
Shop For Success: Experimental Grocery Store Study
The purpose of this research is to study how the price of foods affects food buying choices at the grocery store. The researchers are interested in this topic because the price of foods can have a big impact on what people choose…
- Trial name
- NCT04097262
- Testing
- Own-Price Elasticity, Cross-Price Elasticity
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Loneliness
Developing and Testing a Machine Learning Enabled Mindfulness Intervention for Reducing Loneliness Among Hong Kong Chinese Older Adults
Develop and test an effective machine learning enabled application-based (app-based) mindfulness intervention for reducing loneliness of Hong Kong Chinese older adults.
- Trial name
- NCT07308613
- Testing
- Mindfulness - Continue, Mindfulness - Enhance human coaching, Mindfulness - Booster
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Education University of Hong Kong
Athletic Performance, Attention
Effects of Play Attention Neurofeedback on Attention and Weightlifting Performance in Adolescent Weightlifters
This study looks at whether a 24-week neurofeedback training program called Play Attention can help adolescent weightlifters pay better attention and lift better.
- Conditions
- Athletic Performance, Attention, Neurofeedback, Weightlifting
- Trial name
- Weightlifter (NCT07837310)
- Testing
- Play Attention Neurofeedback-Based Attention Training
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hasan Erdem Mumcu
Respiratory Infections, Acute, Respiratory Syncytial Virus
RSV Challenge in Healthy Adults
The purpose of this study is to measure the immune response (how the body fights infection) to an experimental preparation of live Respiratory Syncytial Virus (RSV).
- Trial name
- NCT00100373
- Testing
- RSV challenge material
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COPD
Investigation on the Role of Corticosteroids and Beta-Agonists on Cytokine Production in COPD Patients
Research on the synergistic effect of corticosteroids and beta-agonists on the cytokine production in COPD patients. Blood will be obtained from healthy volunteers and COPD patients and blood monocytes will be stimulated to…
- Trial name
- NCT00263380
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- St. Antonius Hospital
Asthma, Respiratory Disease
Airway Remodeling and Rhinovirus in Asthmatics
Human rhinovirus is also called the "common cold virus" because it causes at least half of all of the common colds experienced each year.
- Trial name
- ARRA (NCT05775952)
- Testing
- HRV-39
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary