Clinical trials: Eye Allergies
Dry Eye Disease (DED), Dry Eye
Role of Corneal Nerves in Dry Eye Disease
This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss.
- Conditions
- Dry Eye Disease (DED), Dry Eye, Dry Eye Sensation, Corneal Nerve
- Trial name
- NCT06841471
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Daniela Nosch
Skin Care
A Study to Assess the Local Cutaneous and Ocular Tolerance of Three Developmental Facial Skin-care Formulations.
This study aims to determine the local cutaneous and ocular tolerance of 3 developmental skin-care products; a serum, a lotion, and a cream in healthy female subjects with clinically evaluated sensitive facial skin for 21 days.
- Trial name
- NCT04557371
- Testing
- Serum, Lotion, Cream
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cornea
Influence of Silicone Hydrogel Extended Contact Lens Wear on Corneal Sensitivity
Soft contact lens wear reduces the amount of oxygen reaching the eye, which may have an influence on corneal sensitivity. The aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline…
- Trial name
- NCT05298917
- Testing
- silicone hydrogel contact lens
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Daniela Nosch
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity
Oral Proprioceptive Sensitivity and Upper Limb Kinesthetic Acuity: A Pilot Study
The goal of this observational study is to investigate whether differences in oral proprioceptive sensitivity are associated with differences in kinesthetic acuity of the upper limbs in children.
- Trial name
- NCT07854314
- Testing
- Upper-Limb Kinesthetic Acuity Assessment, Effect of Auditory Stimulation on Visual Perception, Oral Proprioceptive Sensitivity Assessment
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sophie Román Richon
Cataract, Signs and Symptoms
Spherical Aberration and Contrast Sensitivity in IOLs
Purpose: To determine whether implantation of an intraocular lens (IOL) with a modified anterior aspheric surface results in reduced spherical aberration and improved contrast sensitivity after cataract surgery.
- Conditions
- Cataract, Signs and Symptoms, Pseudophakia, Lens Diseases
- Trial name
- IOLs (NCT00576485)
- Testing
- Cataract surgery and intraocular lens implantation
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Healthy Volunteers Eligible for Study; Drug Being Developed for Allergic Conjunctivitis
Safety Study of Ophthalmic Solution in Healthy, Normal Volunteers
The purpose of this study is to evaluate the safety of R89674 0.25% ophthalmic solution in healthy normal volunteers
- Trial name
- NCT00223951
- Testing
- R89674 (generic name not yet established)
- Where
- 6 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Vistakon Pharmaceuticals
Allergic Conjunctivitis
Comparison of Tolerability Between Two Allergy Drops
Comfort is compared between two allergy drops
- Trial name
- NCT01390961
- Testing
- alacaftadine and naphazoline HCl & pheniramine maleate
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hom, Milton M., OD, FAAO
Allergic Rhinitis, Asthma
The Effect of Pollen Season on Subcutaneous Allergen Immunotherapy Reactions
Subcutaneous allergen immunotherapy (SCIT) is a widely used and effective treatment modality for allergic rhinoconjunctivitis and asthma.
- Conditions
- Allergic Rhinitis, Asthma, Allergic Conjunctivitis
- Trial name
- SCIT (NCT01878929)
- Testing
- Allergen(Tree, Grass, Weeds)
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Allergic Rhinitis, Allergic Conjunctivitis
Safety and Tolerability of XmAb®7195 in Adult Healthy Volunteers and Adult Subjects With a History of Allergic Rhinitis and/or Allergic Conjunctivitis and/or Atopic Dermatitis
This first-in-human (FIH) study is a randomized, double-blinded, placebo-controlled, ascending dose study to investigate the safety, tolerability, and pharmacokinetics of XmAb7195 in adult healthy volunteers and in adult subjects…
- Conditions
- Allergic Rhinitis, Allergic Conjunctivitis, Atopic Dermatitis
- Trial name
- NCT02148744
- Testing
- XmAb7195
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Cataract After, Astigmatism
Influence of Residual Astigmatism on Visual Acuity in Patients Undergoing Cataract Surgery With Trifocal Intraocular Lens Implantation
MAIN OBJECTIVE: To assess the influence of residual astigmatism on visual acuity in the different lens foci in patients operated on for cataracts with a trifocal intraocular lens implant.
- Conditions
- Cataract After, Astigmatism, IOL, Visual Acuity
- Trial name
- NCT04387721
- Testing
- Kind of trifocal IOL
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Enrique Ordiñaga-Monreal, OD, MSc
Amblyopia
Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia
The research deals with amblyopia or lazy eye, a condition that affects about 3% of the population, and results in a variety of visual deficits.
- Trial name
- NCT03109314
- Testing
- Donepezil, Single-letter training, Uncrowd training
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dennis Levi
Allergic Conjunctivitis
Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses
The purpose of this study is to assess if BEPREVE (bepotastine besilate ophthalmic solution) 1.5% will have an effect on contact lens wear in patients with contact lens intolerance due to allergic conjunctivitis.
- Trial name
- NCT01337557
- Testing
- Bepotastine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hom, Milton M., OD, FAAO
Allergic Rhinitis, Conjunctivitis
Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult Participants
Primary objective: To assess the efficacy of a single dose of the anti- Bet v 1 monoclonal antibodies (mAb(s ) in the reduction of allergic nasal symptoms during an out-of-season birch allergen environmental exposure unit (EEU)…
- Trial name
- NCT05430919
- Testing
- REGN5713, REGN5714, REGN5715
- Where
- 3 sites in Canada
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Training Group, Sensitivity
Developing and Testing a Low Cost Opportunistic Glaucoma Screening Model by Non-physician Graders in Vietnam
This study aims to develop a training course for screening glaucoma using fundus images obtained during diabetic retinopathy screening by non-physician graders.
- Trial name
- NCT05151757
- Testing
- A standard image training set
- Where
- Vietnam
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Keratoconus
Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus
The purpose of this study is to investigate changes in corneal innervation during scleral contact lens wear in a keratoconic population.
- Trial name
- NCT03091101
- Testing
- Scleral lens wearing keratoconics
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Immune Deficiency, Immune Dysregulation Disorder
Allergy and Immunology Natural History Study
This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation.
- Conditions
- Immune Deficiency, Immune Dysregulation Disorder, Allergic Inflammation
- Trial name
- NCT05584488
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Low Vision
Performance of Rigid Gas Permeable (RGP) Scleral Contact Lenses With a Passive Artificial Iris
Data from 15 healthy subjects will be recorded in two testing sessions spread on two days, using three lens designs (A, B and C).
- Trial name
- RGPIRIS_PA (NCT04040790)
- Testing
- Scleral contact lens without a passive artificial iris, Scleral contact lens with a passive artificial iris with low contrast (<1:5), Scleral contact lens with a passive artificial iris with high contrast (>1:5)
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Ghent
Myopia, Hyperopia
Corneal and Conjunctival Sensitivity and Staining Study
The primary objective of this study is to compare subjective symptoms and ocular health in a group of individuals who are currently wearing soft contact lenses on a daily wear basis, after a short period of no lens wear and…
- Trial name
- NCT00455455
- Testing
- Optifree RepleniSH Multipurpose Disinfecting Solution, ReNu Multiplus Multipurpose Solution
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Waterloo