Clinical trials: Eye Disorders
Visual Field Defect, Peripheral, Glaucoma, Open-Angle
Nutritional Supplements and Performance During Visual Field Testing (B3 Vitamin)
This study seeks to test whether these over-the-counter nutritional supplements have an impact on patients' performance during visual field testing.
- Trial name
- NCT03797469
- Testing
- Vitamin B3, Pyruvate
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Retinopathy of Prematurity
Role of Cord Blood Cytokines and Perinatal Factors in Prediction of Retinopathy of Prematurity
Cord blood will be taken after birth for evaluation of cytokines level. At age of 4-6 weeks, we will do fundus examination for babies . Retrograde, we will study the perinatal risk factors in subjects found to have retinopathy.
- Trial name
- NCT04769661
- Testing
- Cytokines
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Corneal Diseases
Ocular Surface Disorders in Patients in Intensive Care Units, a Comparative Study of Three Preventive Approaches
60% of the patients hospitalized in intensive care and sedated suffer from insufficient inferior eyelid occlusion. Thus, they are at risk for corneal damage (estimated risk 20% to 57%).
- Trial name
- OCUREA2 (NCT02348242)
- Testing
- Aqueous Gel, Eyelid Occlusion Dressing, Artificial Tears
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Atopic Dermatitis Eczema, Aging
Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individuals
The study aims to assess the effects of daily consumption of nutrients-fortified eggs on eczema condition in Singapore individuals with eczema.
- Conditions
- Atopic Dermatitis Eczema, Aging, Diet Modification
- Trial name
- NCT06454942
- Testing
- Nutrient-fortified egg, Regular egg with habitual diet
- Where
- Singapore
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Xerophthalmia
Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops
The objective is to evaluate the safety, local tolerability, and pharmacokinetics of NCP112 eye drops through single and multiple dose-escalation ocular administrations in healthy adults.
- Trial name
- NCT06263998
- Testing
- NCP112
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Glaucoma
Comparison Between Handheld Rebound Tonometer and Applanation Tonometer in IOP Measurement in Paediatric Glaucomas
To compare the accuracy between handheld rebound tonometer \& applanation tonometer in IOP measurement in pediatric glaucoma cases
- Trial name
- NCT06766799
- Testing
- Rebound and Applanation Tonometer
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Sohag University
Dry Eye Disease
Optical Coherence Tomography of Tear Film Dynamics In-Vivo
The purpose of this study is to evaluate a new instrument that takes digital images of tear film (a thin film that coats the eye that is made up of oil and water).
- Trial name
- NCT02554084
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Central Retinal Artery Occlusion
Safety and Efficacy After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Trial name
- NCT05562284
- Testing
- intra-arterial thrombolysis, conservative treatments
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Normal Tension Glaucoma
Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost
A randomized, multicenter, investigator-masked prospective study of NTG patients currently on latanoprost 0.005% monotherapy, to study the effect of IOP change with the introduction of netarsudil 0.02% vs brimonidine 0.1%.
- Trial name
- NCT06449352
- Testing
- Netarsudil, Brimonidine
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Westlake Eye Specialists
Glaucoma
Novel Markers for Detecting Early Progression of Glaucoma
Current methods of detecting glaucoma and monitoring its progression over time involve visual assessment of the optic nerve, thickness measurements of nerve tissue in the eye (using optical coherence tomography, OCT) as well as…
- Trial name
- NCT03108443
- Testing
- Optical Coherence tomography angiography
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Balwantray Chauhan
Diabetes, Diabetic Retinopathy
Retinal Blood Flow and Microthrombi in Type 1 Diabetes
The project aims to find mechanisms for the abnormal retinal blood flow that in diabetic patients often precedes any evidence of clinical retinopathy and may contribute to the development of retinopathy.
- Trial name
- NCT00406991
- Testing
- aspirin, clopidogrel
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Schepens Eye Research Institute
Cataract
Satisfaction With Multifocal vs Accommodating Lens Implants 2 Years After Surgery
This study will examine patient satisfaction and spectacle independence using a survey in patients who have undergone uncomplicated cataract surgery with a presbyopia-correcting lens at least 2 years prior to administration of…
- Trial name
- NCT02578524
- Testing
- Survey
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- MDbackline, LLC
Eye Diseases
Screening for Research Participants
This study will allow National Eye Institute (NEI) doctors the opportunity to examine people with eye disease, whether the diagnosis is known or not, to determine if they are eligible for other NEI research studies.
- Trial name
- NCT00655096
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Myopia
Preservative-free Topical Anesthetics for Post-PRK Pain
The goal of this interventional comparative study is to assess the efficacy and safety of a novel regimen of preservative-free unit-dose topical anesthetics for controlling early postoperative pain following single-step…
- Trial name
- NCT05733741
- Testing
- Preservative-free Benoxinate hydrochloride 0.4% (Benoxidia unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt), Preservative-free Sodium hyaluronate 0.2% (Polyfresh unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt).
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Irregular; Contour of Cornea, Keratoconus
Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders
The most common causes for irregular cornea (IC) in hospital contact lens practice are Keratoconus (KC) and related cornea thinning disorders.
- Conditions
- Irregular; Contour of Cornea, Keratoconus, Pellucid Marginal Corneal Degeneration, Injury of Cornea
- Trial name
- NCT02444923
- Testing
- Scleral rigid gas permeable contact lenses (SRGPcl) (Zenlens™), Corneal Rigid gas Permeable contact lenses (CRGPcl) (Rose K2)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- London South Bank University
Retinal Detachment, Epiretinal Membrane
PIONEER: Intraoperative and Perioperative OCT Study
OCT provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. Much of this information is not able to be recognized by a clinician.
- Conditions
- Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
- Trial name
- PIONEER (NCT02423161)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Healthy Volunteers
A Trial to Investigate Teprotumumab (High-concentration Formulation) Subcutaneous Administration in Healthy Adult Non-Japanese and Japanese Participants
The primary objective of this trial are to assess the pharmacokinetics (PK) of a single subcutaneous (SC) administration of teprotumumab high-concentration formula (HCF) in healthy adult non-Japanese and Japanese participants and…
- Trial name
- NCT06674941
- Testing
- Teprotumumab
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Amgen
Open Angle Glaucoma
Micropulse Laser Trabeculoplasty (MLT) Versus Selective Laser Trabeculoplasty (SLT) for Treatment of Open Angle Glaucoma
The purpose of this study is to evaluate the effectiveness of a new laser (called Micropulse Laser Trabeculoplasty or MLT) in the treatment of glaucoma compared to the conventional laser presently used which is called selective…
- Trial name
- NCT01956942
- Testing
- Micropulse Laser Trabeculoplasty, Selective Laser Trabeculoplasty
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- David Belyea
Trachoma
Sanitation, Water, and Instruction in Face-washing for Trachoma I/II
SWIFT I is a series of 3 cluster-randomized trials designed to assess several alternative strategies for trachoma control in communities that have been treated with many years of mass azithromycin distributions.
- Trial name
- SWIFT I/II (NCT02754583)
- Testing
- Water, sanitation, and hygiene (WASH) intervention, Standard of care WASH intervention, Azithromycin
- Where
- Ethiopia
- Volunteers
- 47,605 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Primary Pterygium
The Effects of Primary Pterygium on Contrast Sensitivity Preoperatively and Postoperatively
Pterygium is the growth of conjunctival tissue onto the cornea, usually from the nasal quadrant of the cornea.Visual acuity may be reduced due to direct invasion of the visual axis or astigmatism induced by the pterygium.
- Trial name
- NCT03406390
- Testing
- Pterygium surgery
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
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