Clinical trials: Eye Inflammation
Immune Deficiency, Immune Dysregulation Disorder
Allergy and Immunology Natural History Study
This protocol is a natural history study designed to evaluate subjects (and some family members) with suspected or identified genetic diseases of allergic inflammation or Immune Dysregulation.
- Conditions
- Immune Deficiency, Immune Dysregulation Disorder, Allergic Inflammation
- Trial name
- NCT05584488
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Superior Limbic Keratoconjunctivitis, Conjunctivochalasis
The Role of Cytokines and Mast Cell in the Pathogenesis of SLK, Conjunctivochalasis, and Dry Eye
The specific aims of the the investigators studies are as follows: To collect the tear samples from patients with different ocular surface disorders, including SLK, conjunctivochalasis, and keratoconjunctivitis sicca (KCS).
- Conditions
- Superior Limbic Keratoconjunctivitis, Conjunctivochalasis, Dry Eye
- Trial name
- NCT02160327
- Where
- Taiwan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cataract
Intraocular Steroid After Cataract Surgery Study
The use of one dose of an antibiotic and steroid injected into the eye at the end of cataract surgery is as safe and effective as the post operative use of eyedrops after cataract surgery.
- Trial name
- NCT00478764
- Testing
- intraocular triamcinolone and gatifloxicin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Dean Health System
Keratoconus
Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus
The purpose of this study is to investigate changes in corneal innervation during scleral contact lens wear in a keratoconic population.
- Trial name
- NCT03091101
- Testing
- Scleral lens wearing keratoconics
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Behcet Syndrome
Pan-immune-inflammation Value (PIN) in Behçet's Disease and Its Correlation With Disease Activity
Behçet's disease (BD) is a systemic vasculitis affecting both small and large blood vessels in the venous and arterial systems. It is a multiorgan disease with various manifestations, including mucocutaneous, articular, ocular…
- Trial name
- NCT06729112
- Testing
- pan immune inflammation value
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ocular Inflammation
PGE2 Levels in Patient Treated With NSAIDs
The aim of this study is to determine vitreous levels of nonsteroidal antinflammatory drugs (NSAIDs) and prostaglandinE2 (PGE2) in eyes scheduled for vitrectomy. All patients received the study drugs for 3 days before surgery.
- Trial name
- NCT03597867
- Testing
- Dicloftil, Nevanac, Indom
- Where
- Italy
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Malnutrition, Diabetes
Efficacy of Zinc Fortified Fermented Wheat Flour
Zinc is a pivotal micronutrient that participates in numerous essential metabolic pathways within the human body. Its multifaceted role makes the manifestations of zinc deficiency remarkably nonspecific and age-dependent.
- Conditions
- Malnutrition, Diabetes, Inflammation, Conjunctivitis
- Trial name
- EZAFFAW (NCT06092515)
- Testing
- Fermented High Zinc Wheat Flour Flatbread, Unfermented High Zinc Wheat Flour Flatbread, Post-Harvest Fortified Whole Wheat Flour Flatbread
- Where
- Pakistan
- Volunteers
- 1,044 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Dry Eye, Ocular Inflammation
Closed Eye Neutrophils in Dry Eye Disease
The purpose of this prospective study is to evaluate different inflammatory cells that accumulate on the ocular surface, during sleep, and how these cells may contribute to dry eye disease.
- Trial name
- NCT03332342
- Testing
- Eye wash
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cataract
A Study for Post op Inflammation After Cataract Surgery
This is a randomized, controlled study to assess the safety and effectiveness of treatment with an intracanalicular dexamethasone (0.4mg) insert when utilized in conjunction with topical steroids as part of an extended taper…
- Trial name
- NCT05665270
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate 1%
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wyse Eyecare
Cataract
A Prospective Clinical Study Evaluating Dexycu vs Prednisolone Acetate 1%
This is a post-approval, open-label, randomized, self-controlled prospective clinical study to evaluate the safety and ocular efficacy of Dexycu in controlling postoperative ocular pain and inflammation associated with cataract…
- Trial name
- NCT04273282
- Testing
- Dexycu intracameral dexamethasone, Prednisolone Acetate
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Conjunctivitis, Allergic
OJO-miR: microRNA Expression in Allergic Conjunctivitis.
Allergic conjunctivitis (AC) causes inflammation of the conjunctiva in response to environmental allergens, affecting a significant percentage of the world population and reducing quality of life.
- Trial name
- OJO-miR (NCT07385495)
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Macula; Degeneration, Aging
Impact of Grape Powder Consumption on Eye Health and Glycemic Status in Singapore Older Adults
The purpose of this study is to understand the impacts of regular consumption of freeze-dried table grape powder on eye health and regulation of advanced glycation end products in Singapore older adults.
- Conditions
- Macula; Degeneration, Aging, Advanced Glycation End Products
- Trial name
- NCT06349304
- Testing
- Freeze-dried table grape powder
- Where
- Singapore
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Endophthalmitis
Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis.
There has thus far been only one randomized and masked clinical trial in the world to evaluate the efficacy of the intraoperative intracameral injection of antibiotics with the objective of preventing endophthalmitis following…
- Trial name
- NCT02770729
- Testing
- Moxifloxacin, No injection of moxifloxacin
- Where
- Brazil
- Volunteers
- 3,640 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Retinitis Pigmentosa, Maculopathy, Age Related
Bimodal and Coaxial High Resolution Ophtalmic Imaging
The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- AOSLO-OCT (NCT04620876)
- Testing
- Bimodal high resolution imaging of the retina
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Post-operative Healing Following Blepharoplasty and Ptosis Repair
Efficacy of Loteprednol Ointment Following Eyelid Surgery
Inflammation occurs after any type of incisional surgery. This study will evaluate the efficacy of Loteprednol etabonate ointment vs. Soothe ointment (vehicle) for postoperative inflammation after routine eyelid surgery.
- Trial name
- NCT01749241
- Testing
- Loteprednol etabonate ophthalmic ointment, Vehicle Ophthalmic Ointment
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Intraocular Inflammation
A Comparison of 0.5% Loteprednol Etabonate Versus 1% Prednisolone Acetate Following Cataract Surgery
Patients are routinely given steroid eye drops following cataract surgery. This study will compare 2 approved drops:Loteprednol Etabonate versus Prednisolone Acetate Eye drops used following cataract surgery.
- Trial name
- NCT01384266
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Associated Eye Care, Minnesota
Cataract Senile, Endophthalmitis
Postoperative Safety Outcomes of Intraoperative Intracameral Preservative-Free Moxifloxacin Versus Levofloxacin
Comparative safety study of intracameral levofloxacin versus moxifloxacin for postoperative infection prophylaxis
- Conditions
- Cataract Senile, Endophthalmitis, Antibiotic Side Effect, Safety Issues
- Trial name
- NCT04403334
- Testing
- Levofloxacin Ophthalmic, Moxifloxacin Ophthalmic
- Where
- Philippines
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Peregrine Eye and Laser Institute
Intraocular Lens Complication, Intraocular Lens Rotation
Intraocular Lens Implant Registry Study
The goal of this registry study is to optimize the results with intraocular lens implants used in cataract surgery.
- Conditions
- Intraocular Lens Complication, Intraocular Lens Rotation, Intraocular Lens Associated Postoperative Inflammation, Lens Opacities
- Trial name
- NCT06294405
- Testing
- Intraocular lens Implantation
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Hospital Augsburg
Healthy
Naturally Produced Cannabinoids for Neuroprotection From Concussion
The goal of this double-blind, placebo-controlled, cross over study is to learn about the neuroprotective properties of a broad-spectrum cannabinoid formulation in normal healthy adults engaged in elite contact sport competition.
- Trial name
- NCT07715864
- Testing
- Broad spectrum cannabinoid formulation
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Regina
Menopausal Syndrome, Cognitive Decline
Algal Lutein Against Decline of Intellectual Nimbleness
Lutein is a xanthophyll pigment found in photosynthesizing organisms. Its beneficial effects on health, including brain function and visual performance, have been recognized for many years.
- Conditions
- Menopausal Syndrome, Cognitive Decline, Obesity & Overweight, Menopause
- Trial name
- ALADIN (NCT07600567)
- Testing
- Lutein
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Life Sciences