Clinical trials: Eye Inflammation
Chlamydia Infections, Ophthalmia Neonatorum
Clinical Trial of Eye Prophylaxis in the Newborn
To compare the effectiveness of silver nitrate drops, erythromycin ointment, or no medication in preventing neonatal conjunctivitis caused by Chlamydia trachomatis and other eye infections.
- Trial name
- NCT00000120
- Testing
- Erythromycin Ointment, Silver Nitrate Drops
- Sponsor
- National Eye Institute (NEI)
Non-infectious Anterior Uveitis, Non-infectious Intermediate Uveitis
Efficacy and Safety of Adalimumab for the Treatment of Ocular Inflammation
This study aims to evaluate the clinical efficacy and safety of adalimumab in pediatric non-infectious uveitis and to generate domestic real-world evidence (RWE), thereby establishing a clinical foundation for label expansion and…
- Conditions
- Non-infectious Anterior Uveitis, Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Panuveitis
- Trial name
- PANDA-U (NCT07913750)
- Testing
- Adalimumab PFS and Pen
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Inflammation, Bacterial Infections
Sub-Tenon's Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery
The purpose of this study is to compare one intraoperative sub-Tenon's capsule injection of triamcinolone and ciprofloxacin in a biodegradable controlled-release system with conventional prednisolone and ciprofloxacin eye drops…
- Trial name
- NCT00431028
- Testing
- slow delivery ciprofloxacin + triamcinolone
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Federal University of São Paulo
Ocular Inflammation
Triamcinolone Versus Topical Treatment in Post Operative Phacoemulsification
Cataract extraction is one of the most common operative procedures performed throughout the world. Conventionally, patients are discharged with postoperative drops of steroids and antibiotics or a combination of both.
- Trial name
- NCT00789971
- Testing
- triamcinolone acetonide, Maxitriol
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- Sligo General Hospital
Dry Eye
Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED)
This prospective, single-center, randomized, double-masked, parallel comparison, sponsored study seeks to investigate the efficacy of Intracanalicular dexamethasone Insert (IDI) on ameliorating the signs and symptoms of dry eye…
- Trial name
- DEcIDED (NCT04527887)
- Testing
- Dextenza (IDI) (Sustained Release Dexamethasone), (0.4 mg), ProLong™ collagen plugs
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Tufts Medical Center
Uveitis, Posterior, Uveitis, Intermediate
Safety and Effectiveness of Acthar Gel for Inflammation of the Eye's Uvea (Middle Layer)
The main reason for this study is to see if Acthar Gel can reduce inflammation in the uvea. Also, safety information when using it for this purpose will be collected.
- Conditions
- Uveitis, Posterior, Uveitis, Intermediate, Panuveitis
- Trial name
- NCT03656692
- Testing
- Acthar Gel
- Where
- 8 sites in United States
- Volunteers
- 5 people
- Sponsor
- Mallinckrodt
Intraocular Inflammation, Retinal Vascular Occlusion
Analysis of Imaging Features From Patients Treated With Brolucizumab in the Post-marketing Setting With Reports of Retinal Vasculitis and/or Retinal Vascular Occlusion
This non-interventional descriptive study was undertaken to better understand the most common imaging features associated with inflammation arising in the post-marketing setting when brolucizumab was prescribed in routine…
- Trial name
- NCT05657158
- Testing
- Brolucizumab
- Where
- Switzerland
- Volunteers
- 198 people
- Sponsor
- Novartis Pharmaceuticals
Endophthalmitis Postoperative
A Two Chemoprophylaxis Approaches After Phacoemulsification Surgery
Post cataract surgery bacterial endophthalmitis is a rare but the most devastating complication with a poor visual outcome. The preferred pattern of chemoprophylaxis varied world widely.
- Trial name
- NCT03634852
- Testing
- Moxifloxacin hydrochloride 0.5% eye drops, Dexamethasone 0.1% eye drops, Intracameral Moxifloxacin 0.1%
- Volunteers
- 1,000 people
- Sponsor
- Suzan A Rattan
Endophthalmitis Postoperative
Intracameral Levofloxacin (0.5%) vs Intracameral Cefuroxime
Endophthalmitis is a clinical diagnosis made when intraocular inflammation involving both posterior and anterior chamber; is attributable to bacterial or fungal infection.
- Trial name
- NCT04212078
- Testing
- Levofloxacin Ophthalmic, Cefuroxime
- Where
- Malaysia
- Volunteers
- 138 people
- Sponsor
- National University of Malaysia
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Malnutrition, Diabetes
Efficacy of Zinc Fortified Fermented Wheat Flour
Zinc is a pivotal micronutrient that participates in numerous essential metabolic pathways within the human body. Its multifaceted role makes the manifestations of zinc deficiency remarkably nonspecific and age-dependent.
- Conditions
- Malnutrition, Diabetes, Inflammation, Conjunctivitis
- Trial name
- EZAFFAW (NCT06092515)
- Testing
- Fermented High Zinc Wheat Flour Flatbread, Unfermented High Zinc Wheat Flour Flatbread, Post-Harvest Fortified Whole Wheat Flour Flatbread
- Where
- Pakistan
- Volunteers
- 1,044 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Eye Diseases, Eye Infections
The EXPLORE Study - The Use of Binocular OCT Imaging for the Assessment of Ocular Disease
Optical coherence tomography (OCT) is an imaging modality, first described in 1991, that provides cross-sectional images of the eye in a non-invasive manner.
- Conditions
- Eye Diseases, Eye Infections, Eye Inflammation
- Trial name
- NCT03553017
- Testing
- Binocular OCT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Uveomeningoencephalitic Syndrome, Inflammation
Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I
Patients with acute onset Vogt-Koyanagi-Harada disease (VKHD) were prospectively included in this study. They were systematically followed with clinical, posterior segment imaging exams and full-field electroretinogram during a…
- Conditions
- Uveomeningoencephalitic Syndrome, Inflammation, Choroid Disease, Visual Impairment
- Trial name
- NCT03811366
- Testing
- Corticosteroid monotherapy
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- University of Sao Paulo
Eye Disease, Inflammation
Analysis of Eye Tissue
The purpose of this investigation is to better understand the inflammatory process that occurs in uveitis (eye inflammation) through study of eye tissues.
- Conditions
- Eye Disease, Inflammation, Uveitis
- Trial name
- NCT00001224
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Eye Institute (NEI)
Endophthalmitis, Infectious Endophthalmitis
Vitrectomy Combined With Povidone-Iodine Vitreous Irrigation for Infectious Endophthalmitis
Infectious endophthalmitis is a severe infection inside the eye that can rapidly cause permanent vision loss or loss of the eye.
- Trial name
- NCT07888205
- Testing
- Povidone-iodine intravitreal irrigation with povidone-iodine containing 0.0025% available iodine, BSS intravitreal irrigation solution
- Volunteers
- 38 people
- Sponsor
- Beijing Tongren Hospital
Dry Eye Disease (DED)
Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation
Dry eye disease (DED) is a highly prevalent ocular condition and induces a significant burden to the affected patients. Regardless of the underlying etiology, DED is associated with increased inflammation of the entire ocular…
- Trial name
- NCT07245836
- Testing
- Thealoz Total® Eye Drops, Laboratoires Thea, Clermont Ferrand, France
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Glaucoma, Open-Angle, Ocular Hypertension
Inflammatory Biomarkers in Ocular Surface in Primary Open Angle Glaucoma or Ocular Hypertension Under Topical Prostaglandins
Glaucoma is a chronic optic neuropathy whose main modifiable risk factor is an abnormally elevated intraocular pressure. The aim of glaucoma treatment is to slow the progression of the disease by reducing intraocular pressure.
- Trial name
- NCT05039684
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Arthritis, Juvenile Rheumatoid, Uveitis
The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis
Current treatment modalities for uveitis associated with juvenile rheumatoid arthritis have not been beneficial in the juvenile population.
- Trial name
- NCT00001614
- Testing
- Chicken type II collagen
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Eye Institute (NEI)
Ocular Inflammation, Ocular Prostheses
Comparison of Topical Treatment for Inflammatory Secretions of the Conjonctiva (Patients With Ocular Prostheses)
We propose to evaluate the efficacy of treatment with Hydrocortisone and Dexamethasone (in a cross-over design) in patients with ocular prostheses and significant functional discomfort.
- Trial name
- CRYSTAL (NCT05668455)
- Testing
- Hydrocortisone, Dexamethasone, Povidone
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Agnes
Blepharitis, Conjunctivitis
Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis
Safety and efficacy of antibiotic steroid combination compared with individual administration in the treatment of bacterial ocular inflammation and infection (blepharitis and/or keratitis and/or conjunctivitis).
- Conditions
- Blepharitis, Conjunctivitis, Keratitis
- Trial name
- BRA-07-02 (NCT00732446)
- Testing
- Moxifloxacin and Dexamethasone combined, Moxifloxacin, Dexamethasone
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo