Clinical trials: Eye Injuries
Alzheimer Disease
Identification of Diagnosis Biomarkers in the Tears of Alzheimer's Disease Patients: The COG-EYE Pilot Study
The diagnosis of Alzheimer's disease (AD) relies on the detection of protein biomarkers, particularly in cerebrospinal fluid (e.g., Aβ and phosphorylated Tau) or through brain imaging.
- Trial name
- COG-EYE (NCT06661564)
- Testing
- Basal tear collection for the analysis of metabo-lipidomic profiles and concentrations of protein biomarkers (Tau, phosphorylated Tau, Aβ 1-40, and Aβ 1-42), Collection of a blood sample (5 mL) for blood biomarkers analysis
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Conjunctival Infections, Irritations and Inflammations, Hypertrophy; Conjunctiva
Influence of Cosmetic Color Tinted Contact Lenses on the Ocular Surface
More than 1 million people worldwide wear soft contact lenses for refractive error correction. However, severe sight threatening complications due to contact lens wear such as contact lens-related microbial keratitis (CLMK) are…
- Conditions
- Conjunctival Infections, Irritations and Inflammations, Hypertrophy; Conjunctiva, Corneal Pannus, Corneal Epithelial Wound
- Trial name
- NCT01441648
- Testing
- contact lens wear
- Where
- Taiwan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Post-Traumatic Stress Disorder
Study of Eye Movement Desensitization and Reprocessing (EMDR) Working Mechanism
EMDR (Eye Movement Desensitization and Reprocessing) is an exposure-based procedure for the treatment of patients with post-traumatic stress disorder (PTSD).
- Trial name
- NCT01209377
- Testing
- standard, fixed, no focus
- Where
- Germany
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Eye Injuries
Comparison of the Effects on Promoting Corneal Epithelial Wound Healing Between Human Auto-Serum and Cord Blood Serum
Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing.
- Trial name
- NCT00598299
- Testing
- venous puncture, obtain serum from perripheral blood or cord blood
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hyperextension Injury of Neck
Effects of Cervical Hyperextension on Cervical Blood Flow, Cerebral Oximetry and Cognitive Functions.
The goal of this observational study is to determine the effects of cervical hyperextension on cerebral oximetry and cognitive functions in healthy individuals without other additional factors such as anesthesia and surgical…
- Trial name
- NCT05576857
- Testing
- Doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Duzce University
Posttraumatic Stress Disorder
Results From a 24 Week Trial of EMDR Combined With Venlafaxine XR
Approximately 150 active duty service members meeting Diagnostic and Statistical Manual version 5 (DSM-5) criteria for posttraumatic stress disorder (PTSD) and scoring 50 or above on the Clinician Administered PTSD Score for…
- Trial name
- EMDRVEN (NCT02433353)
- Testing
- Venlafaxine XR, EMDR
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bayne-Jones Army Community Hospital
Amyotrophic Lateral Sclerosis
Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is the most common neurodegenerative disease affecting the motor neuron. Currently, there is no diagnostic test and no examination that can predict the evolution of this pathology.
- Trial name
- LARMOMIQUE (NCT04953286)
- Testing
- Measure of visual acuity, Interferometry, Samples of basal tears
- Where
- 3 sites in France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Rare Diseases, Aniridia
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with…
- Conditions
- Rare Diseases, Aniridia, Neurotrophic Keratopathy, Limbal Stem Cell Deficiency
- Trial name
- NCT06412718
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Mild Traumatic Brain Injury, Brain Concussion
Testing mTBI in Athletes
This study will assess the effectiveness of a portable goggle system in the diagnosis of mild traumatic brain injury (mTBI) in athletes.
- Trial name
- NCT02486003
- Where
- United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- University of Miami
Ocular Injury
An Observational, Qualitative Study Assessing Eye Drop Administration
This is a prospective, observational, consecutive, qualitative, multicenter study. Based on the available published evidence that supports patient challenges with eyedrop administration, the purpose of this video-capture study is…
- Trial name
- NCT05307081
- Testing
- Artificial Tears
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ocular Therapeutix, Inc.
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution, High-speed Multimodal Ophthalmic Imaging
Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IMA-MODE (NCT04129021)
- Testing
- High-resolution retinal imaging through adaptive optics, High-resolution retinal imaging through holographic systems
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Pupil Constriction, Iris Floppiness
Clinical Factors Associated Floppy Iris
This study is planned to investigate the incidence of intraoperative floppy iris and its relationship with pseudoexfoliation, diabetes, hypertension as well as systemic alpha-1 adrenergic blocker use.
- Conditions
- Pupil Constriction, Iris Floppiness, Iris Prolapsus From the Wound
- Trial name
- NCT00472888
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Baskent University
Brain Concussion, mTBI - Mild Traumatic Brain Injury
Screening Instruments for Measuring Visual Symptoms in Victims of Concussion
Visual dysfunction after mild traumatic brain injury (mTBI) is common but often remain undiscovered during longer periods of time. No valid, reliable and easy-to-use screening instrument for uncovering visual dysfunction exists.
- Trial name
- VisCom (NCT05862571)
- Where
- Denmark
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Eye Diseases, Ophthalmic Trauma
Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.
This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or disease.
- Conditions
- Eye Diseases, Ophthalmic Trauma, Mitochondrial DNA, Age Related Macular Degeneration
- Trial name
- NCT04334499
- Testing
- Sample collection from tissue discard
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cornea Injury
Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing
For severe ocular surface diseases, such as chemical and thermal injuries, Stevens-Johnson syndrome (SJS), Band Keratopathy, Corneal Dystrophies, Refractive (PRK-LASEK), corneal surgery and others, it is important that short time…
- Trial name
- NCT02746848
- Testing
- Amniotic Membrane Extract Eye Drop
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Post-Traumatic Stress Disorder
Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep
The overarching aim of this Exploratory/Developmental Research Grant Award (R21) is to explore the neurobiological correlates of PTSD during REM sleep by using state-of-the science positron emission tomography (PET) sleep…
- Trial name
- REM-P (NCT00871650)
- Testing
- Sleep data recording, PET scan - waking, PET scan - REM Sleep
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
PTSD
Senseye's OBCI Diagnostic Tool for PTSD
This pilot study will investigate the feasibility, acceptability, repeatability, accuracy and efficacy of the Senseye OBCI diagnostic tool to assess the presence and severity of PTSD symptoms and monitor response to…
- Trial name
- NCT05372523
- Testing
- CAPS-5 Assessment, Senseye OBCI
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Senseye, Inc.
Blindness, Spinal Cord Injury
Use of "Smart Wheelchairs" to Provide Independent Mobility to Visual and Mobility Impairments
The goal of this project is to evaluate the Smart Wheelchair Component System (SWCS) for power wheelchairs and the Smart Power Assistance Module (SPAM) for manual wheelchairs in realistic indoor environments with target users…
- Trial name
- NCT00333762
- Testing
- Smart Power Assistance Module (SPAM), Smart Wheelchair Component System (SWCS)
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development