Clinical trials: Eye Movement Disorder
Rapid Eye Movement Sleep Behavior Disorder
RBD Longitudinal as Prognostic for PD
Purpose - to validate a combination of biological and clinical markers in the rapid-eye-movement (REM) sleep behavior disorder (RBD) population as indicative of the pre-symptomatic stage of Parkinson's disease (PD).
- Trial name
- RBD6YR (NCT00817726)
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
α-synucleinopathy, Parkinson's Disease (PD)
[18F] - FD17 PET Imaging of α-synuclein: A Clinical Study in α-synucleinopathy Patients
The main objective of this study is to establish a standardized method for [18F] - FD17 PET imaging in α-synucleinopathy patients, and to analyze its physiological distribution in healthy individuals as well as its pathological…
- Conditions
- α-synucleinopathy, Parkinson's Disease (PD), Multiple System Atrophy, Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- NCT06738862
- Testing
- PET
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Reading Disability, Dyslexia
Eye Movements and Reading Disabilities
The mechanism of the eye movement anomalies seen in dyslexic patients is not well defined. Some optometrists use observational eye movement tests as screening devices for dyslexia and advocate eye movement therapy as a treatment…
- Trial name
- EOMRD (NCT01860027)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Parkinson Disease, Multiple System Atrophy
Diagnostic and Prognostic Biomarkers in Parkinson Disease
The overall goal of PROBE is to evaluate the feasibility and potential utility of three markers (alpha-synuclein, transcriptomic profiles and olfactory function) to determine the risk or prognosis of PD.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- PROBE (NCT00653783)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Parkinson Study Group
Parkinson Disease, Progressive Supranuclear Palsy(PSP)
Parkinson Atypical Rating of Oculometric Patterns Evaluated Routinely
This is an observational longitudinal study in 4 cohorts of patients with Parkinsonian syndromes, who are visiting the Movement Disorders outpatient clinics.
- Conditions
- Parkinson Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy
- Trial name
- PARATROOPER (NCT06597071)
- Testing
- NeuraLight PD, NeuraLight PSP, NeuraLight MSA
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NeuraLight
Schizophrenia, Cognitive Impairment
Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum
The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode…
- Conditions
- Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis
- Trial name
- NCT07702526
- Testing
- Eye-Movement Training, Finger-Controlled Game Training
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Strabismus, Exotropia
A Novel Diagnostic Method for Exotropia Using Video-oculography
Thirty-four subjects with constant exotropia were included. Two independent ophthalmologists measured the angle of ocular deviation using alternate prism cover test (APCT).
- Trial name
- NCT03119311
- Testing
- Video-oculography, APCT
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Inje University
Parkinson Disease
Study of Comprehension and Execution of Medication Prescriptions in Parkinsonian Patients and Healthy Volunteers
Many patients with Parkinson's disease (Pd) don't respect medication prescriptions. Non-adherence is caused by several factors among which three play an important role: treatment complexity, cognitive decline, and…
- Trial name
- TACTIPARK (NCT03976505)
- Testing
- reading a table format prescription on a touch screen, reading a textual format prescription on a touch screen, filling a virtual pillbox displayed on the screen as prescribed in the prescription
- Where
- France
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Progressive Supranuclear Palsy
Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy
The main hypothesis is that the gait and postural deficits in the Caribbean form of PSP may be associated with a dysfunction of the cerebral cortex, as they result from sub-cortical involvement in classical forms.
- Trial name
- Gait-PSP (NCT04096651)
- Testing
- gait recordings, brain magnetic resonance imaging, oculomotor movement recordings
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Atypical Parkinsonism
Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans
The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.
- Trial name
- CAP (NCT03368300)
- Testing
- Clinical and biological exam
- Where
- 2 sites in French Guiana, Martinique
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Optokinetic Nystagmus
Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Healthy Volunteer Trial
Clinical investigation of a medical device (CAVA) for recording eye movements. Healthy volunteers will wear the device for 23 hours a day, for 30 days.
- Trial name
- CAVA (NCT03661762)
- Testing
- CAVA
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Julie Dawson
Cycloplegia, Refractive Errors
Cycloplegic Refraction in Pediatric Patients With Esotropia
The primary outcome of this study is to compare cyclopentolate 1% and tropicamide 1% for cycloplegic refractions in pediatric populations with esotropia.
- Conditions
- Cycloplegia, Refractive Errors, Esotropia, Vision Disorders
- Trial name
- NCT06077682
- Testing
- Cyclopentolate, Tropicamide
- Where
- 2 sites in Jordan, Qatar
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Islamic Hospital, Jordan
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Huntington Disease, Autobiographical Memory
Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease
Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by progressively worsening motor, cognitive, psychiatric, and behavioral deficits.
- Trial name
- MAMOC-MH (NCT07409597)
- Testing
- neuropsychological tests, Eye tracker use
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Alzheimer Disease, Mild Cognitive Impairment
Tau Imaging With JNJ067
This protocol is designed to assess the utility of a new positron emission tomography (PET) radiopharmaceutical to image tau, [18F] JNJ067, invented by Janssen Pharmaceutical companies of Johnson \& Johnson.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Progressive Supranuclear Palsy
- Trial name
- NCT03926702
- Testing
- Radiopharmaceuticals
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
PARKINSON DISEASE (Disorder), Atypical Parkinsonism
Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes
This prospective observational study aims to identify and preliminarily validate molecular biomarkers, including microRNAs and metabolites, for the early differentiation of Parkinson's disease (PD) from atypical parkinsonian…
- Conditions
- PARKINSON DISEASE (Disorder), Atypical Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy (PSP)
- Trial name
- BIOMARK-PS (NCT07604883)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Institute of Molecular and Cell Biology in Warsaw
Amblyopia, Strabismus
Screening for 3-D Visual Disorders in Preschool Children
Visual screening is necessary among pre-school children as they found themselves in a critical period of visual developement. To date, there are no national vision screening program that has been implemented nationwide.
- Conditions
- Amblyopia, Strabismus, Anisometropia
- Trial name
- VISION (NCT05204069)
- Testing
- Instillation of cyclopentolate
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Registry
With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NDD Registry (NCT04472130)
- Where
- Hong Kong
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Vincent Mok
Frontotemporal Dementia, Progressive Supranuclear Palsy
Study of the Neural Basis of Analogical Reasoning
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks.
- Conditions
- Frontotemporal Dementia, Progressive Supranuclear Palsy, Healthy Subjects
- Trial name
- ANALOG (NCT02236832)
- Testing
- transcranial magnetic stimulation, MRI imaging, EEG recording
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson's Disease, Parkinsonism
VisMemoPD Protocol: an Observational Pilot Study on Spatial and Topographical Memory in Patients With Parkinson's Disease and Parkinsonism
VISMEMO-PD is an observational pilot study aimed at investigating visuospatial memory in reaching space and topographical memory in navigational space in patients with Parkinson's disease and Parkinsonism.
- Conditions
- Parkinson's Disease, Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- VISMEMO-PD (NCT07827963)
- Testing
- Multimodal visuospatial and topographical memory assessment
- Where
- 3 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma