Clinical trials: Eye Movements
Alzheimer Disease, Progressive Supranuclear Palsy
Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases
Tau protein has been identified as one of the key pathological features of Tau proteinopathies, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD).
- Conditions
- Alzheimer Disease, Progressive Supranuclear Palsy, Frontotemporal Dementia
- Trial name
- NCT05260151
- Where
- China
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS)
4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
The goal of this study is to identify the most reliable methods of analysis for tracking CBD, PSP, and o/vPSP over time. The results from this study may be used in the future to calculate statistical power for clinical drug…
- Conditions
- Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS), Cortical-basal Ganglionic Degeneration (CBGD), Progressive Supranuclear Palsy (PSP)
- Trial name
- 4RTNI-2 (NCT02966145)
- Testing
- Observational Study
- Where
- 8 sites in United States, Canada
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Parkinson's Disease, Alzheimer's Disease
Biomarkers in Neural Disorders
This study seeks to establish the sensitivity and specificity of what appears to be a unique brainstem biomarker of Parkinson's Disease (PD) - an electrically induced olygosynaptic nasotrigeminal reflex response - in…
- Conditions
- Parkinson's Disease, Alzheimer's Disease, Progressive Supranuclear Palsy, Essential Tremor
- Trial name
- NCT02761707
- Testing
- Electrical Brainstem Responses, Olfactory Tests, Visual Deprivation
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Trauma, Psychological
Systematic Case Series Investigating Eye Movement Desensitization Reprocessing (EMDR) Efficacy With Childhood Sexual Abuse Survivors
This study investigates the effectiveness of EMDR for survivors of childhood sexual abuse. All participants will undertake a standard course of EMDR via the National Heath Service program, alongside a number of questionnaires and…
- Trial name
- EMDR (NCT03966963)
- Testing
- Eye Movement Desensitization Reprocessing (EMDR)
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Salford
Parkinson Disease, Gaucher Disease
Detecting Dopaminergic Deficits in Individuals At-risk for Parkinsonism
The purpose of this study is to determine if participants have changes in dopamine cells in their brain using DaTSCAN™ brain imaging.
- Conditions
- Parkinson Disease, Gaucher Disease, Idiopathic Rapid Eye Movement Sleep Disorder
- Trial name
- NCT01358474
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Intermittent Exotropia, Strabismus
The Analysis of Ocular Deviations Between Dominant and Non-dominant Eye Using Video-oculography (VOG) in Intermittent Exotropia
Fifteen subjects with intermittent exotropia were included. The subjects were asked to fixate on a black-on-white optotype at 1 m, which subtended a visual angle of 50 min of arc, equating to a Snellen optotype of 20/200.
- Trial name
- NCT03641040
- Testing
- Video-oculography, Alternative prism cover test
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Inje University
Healthy
Impact of Osteopathic Manipulative Treatment on Pursuit Eye Movements in Healthy Human Adults
The idea that osteopathic manipulative treatments (OMTs) should have an impact on the human visual system is not new. Nevertheless, there is a lack of scientific, objective, and experimental evidence.
- Trial name
- NCT05018390
- Testing
- Osteopathic manipulative treatment
- Where
- France
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Ecole d'ostéopathie de Paris
Frontotemporal Dementia, Progressive Supranuclear Palsy
Study of the Neural Basis of Analogical Reasoning
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks.
- Conditions
- Frontotemporal Dementia, Progressive Supranuclear Palsy, Healthy Subjects
- Trial name
- ANALOG (NCT02236832)
- Testing
- transcranial magnetic stimulation, MRI imaging, EEG recording
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Convergence Insufficiency
Objective Assessment of Disparity Vergence After Treatment of Symptomatic CI in Children
This study is designed to evaluate changes in objective measures of disparity vergence after office-based vergence/accommodative therapy (OBVAT) for convergence insufficiency (CI) in children 12-17 years old.
- Trial name
- NCT03248336
- Testing
- office-based vergence/accommodative therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Salus University
Binocular Vision Disorder, Convergence Insufficiency
Neurolens Headache Study
To understand the benefits of the neurolens Measurement Device and neurolens treatment as it pertains to treating symptoms related to Chronic Headaches.
- Conditions
- Binocular Vision Disorder, Convergence Insufficiency, Headache, Computer Vision Syndrome
- Trial name
- NCT05070767
- Testing
- Neurolens spectacle lens
- Where
- 10 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Neurolens Inc.
Schizophrenia
Internal Monitoring of Eye Movement in Schizophrenia
Background: Researchers are studying how humans are able to move our eyes to a remembered region even when the target has disappeared.
- Trial name
- NCT01011101
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Progressive Supranuclear Palsy
Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy
The main hypothesis is that the gait and postural deficits in the Caribbean form of PSP may be associated with a dysfunction of the cerebral cortex, as they result from sub-cortical involvement in classical forms.
- Trial name
- Gait-PSP (NCT04096651)
- Testing
- gait recordings, brain magnetic resonance imaging, oculomotor movement recordings
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Vision Disorders, Eye; Movement Disorder (Binocular)
Characteristics of the Vergence Responses of Binocularly Normal Subjects After a Vision Therapy Protocol
A vision therapy protocol for vergence ability is mentioned. The purpose of this study is to evaluate objectively the change in the vergence responses of binocular and accommodative normal subjects after performing a classic…
- Conditions
- Vision Disorders, Eye; Movement Disorder (Binocular), Vision Therapy, Binocular Vision Disorder
- Trial name
- NCT05208658
- Testing
- Experimental: Classical Vision Therapy Treatment, Control: Eye Movement Therapy Treatment
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universitat Politècnica de Catalunya
Cerebellum Disease
Eye Movements and Visuo-spatial Perception
This research aims to highlight the key roles of the cerebellar and cortical fronto-parietal networks in the coupling of eye movements with visual perception and visuo-spatial attention.
- Trial name
- NCT03112408
- Testing
- Forward adaptation of reactive saccades, Backward adaptation of reactive saccades, Execution of reactive saccades
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Myopia, Strabismus
Evaluation of a County-Based Eye Health Service Model in Rural Chinese Children
This project proposes to conduct a prospective, multicenter registry study in rural China to evaluate, under real-world conditions, the implementation effectiveness of an integrated child eye health service model centered at the…
- Conditions
- Myopia, Strabismus, Eye Health
- Trial name
- NCT07547748
- Testing
- School-based Eye Health Screening
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Functional Neuroimaging
Effects of Ketamine on Eye Movements, Perception and Brain Function
In this study, the investigators examine the effects of low-dose ketamine on different oculomotor, perceptual and cognitive functions.
- Trial name
- NCT02701933
- Testing
- Ketamine, Saline
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Esotropia
Vision Therapy Versus Prism Treatment in Small-angle Acute Acquired Concomitant Esotropia
This prospective, single-center, nonrandomized comparative study evaluates 6-month ocular alignment and binocular visual function outcomes following combined accommodation and fusional training or prism correction in patients…
- Trial name
- NCT06622044
- Testing
- Vision therapy group, Prism
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Depression, Anxiety, Post-traumatic Stress Symptoms
Predictors and Process Moderators of EMDR Therapy for Depressive Symptoms
The goal of this clinical trial is to evaluate which factors influence the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy for depressive symptoms in real-world settings in Italy.
- Conditions
- Depression, Anxiety, Post-traumatic Stress Symptoms, Dissociation, Psychotherapy Research and Outcome Measures
- Trial name
- PROCESS-EMDR (NCT07033741)
- Testing
- EMDR
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Parkinson Disease, Progressive Supranuclear Palsy(PSP)
Parkinson Atypical Rating of Oculometric Patterns Evaluated Routinely
This is an observational longitudinal study in 4 cohorts of patients with Parkinsonian syndromes, who are visiting the Movement Disorders outpatient clinics.
- Conditions
- Parkinson Disease, Progressive Supranuclear Palsy(PSP), Multiple System Atrophy
- Trial name
- PARATROOPER (NCT06597071)
- Testing
- NeuraLight PD, NeuraLight PSP, NeuraLight MSA
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NeuraLight
Marfan's Syndrome With Ocular Manifestations, Pseudoexfoliation Syndrome
The Oscillation of Crystalline and Intraocular Lenses
The crystalline lens of the human eye helps to sharpen vision. There can be issues with the support/stability of the lens. This could be seen with the naked eye of an external observer or with the use of a slit lamp.
- Conditions
- Marfan's Syndrome With Ocular Manifestations, Pseudoexfoliation Syndrome, Cataract, Phakodonesis
- Trial name
- NCT04274634
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University