Clinical trials: Flow Cytometry
Myeloma Multiple
The Risk Stratification in Patients With Multiple Myeloma Based on Fluorescence Flow Cytometry Quantitative Determination of the Circulating Plasma Cells in the Peripheral Blood
The main aim of this study is to evaluate the effectiveness of the clinical application of the XN-1000/20 hematology analyzer for risk stratification in patients with multiple myeloma based on the number of detected plasma cells…
- Trial name
- NCT04242121
- Testing
- fluorescence flow cytometry
- Where
- Russia
- Volunteers
- 24 people
- Sponsor
- Ivan S Moiseev
Transplant; Failure, Kidney
Effects of Sevoflurane and Desflurane on Treg
This prospective interventional study aims to compare sevoflurane and desflurane anesthetic agents on regulatory T cell (Treg) numbers and its cytokine production in patients undergoing Living Donor Kidney Transplant (LDKT).
- Trial name
- NCT02559297
- Testing
- Sevoflurane, Desflurane
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Myelodysplastic Syndromes
Predictive Value of Myelodysplastic Syndrome Stem Cells Determined by Multiparameter Flow Cytometry
Presently, multiparameter flow cytometry (MFC) and polymerase chain reaction (PCR) have been used for disease load, including measurable residual disease (MRD), monitoring in patients with myelodysplastic syndrome (MDS).
- Trial name
- NCT06569095
- Testing
- Detection of MDS-SC using MFC
- Where
- 4 sites in China
- Volunteers
- 163 people
- Sponsor
- Peking University People's Hospital
Critical Illness, Intensive Care Patients
IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients
This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU).
- Conditions
- Critical Illness, Intensive Care Patients, Critical Illness Requiring Intensive Care - Sepsis, Critical Illness Requiring Intensive Care - Acute Brain Injury
- Trial name
- IMMUNOREA (NCT07345169)
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myelodysplastic Syndromes
Flow Cytometric Analysis of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes: Protocol for a Diagnostic Accuracy Study
Myelodysplastic syndromes (MDS) are clonal bone marrow neoplasms characterized by dysplasia and ineffective hematopoiesis leading to peripheral blood cytopenias, with an increased risk of progression to acute myeloid leukemia.
- Trial name
- MPO-MDS-Valid (NCT05175469)
- Testing
- Flow cytometric analysis of neutrophil myeloperoxidase expression
- Where
- 8 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Sperm Capacitation
Capacitation-associated Protein Tyrosine Phosphorylation As a Possible Biomarker of Sperm Selection
Sperm undergo complex selection processes and physiological changes as they move through the female reproductive tract. Ejaculated-sperm must undergo a set of molecular and biochemical changes globally named as capacitation in…
- Trial name
- FOSFOTIR (NCT04962100)
- Testing
- Analysis of capacitation-associated tyrosine phosphorylation in human sperm by flow cytometry
- Where
- Spain
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Membranous Nephropathy, Minimal Change Disease (MCD)
Immunophenotyping Profiling in Patients With Primary Nephrotic Syndrome
Immunophenotyping profiling of patients with primary MN, primary FSGS and MCD. Evaluation of these immune cell subsets as possible biomarkers to track response to treatment or disease relapse.
- Conditions
- Membranous Nephropathy, Minimal Change Disease (MCD), Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- NCT07702981
- Testing
- Rituximab (MABTHERA® or RITUXAN®)., Corticosteroids (CS)
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ioannina
Healthy
Effect of Smoking and Time of Day on Eosinophils
The study investigates the effect of acute smoking and time of day on blood eosinophils in chronic smokers. Chronic cigarette smokers without chronic respiratory diseases smoking at least 8 cigarettes per day and never-smoking…
- Trial name
- NCT07625111
- Testing
- Smoking for 4 hours
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marek Lommatzsch
Cardiac Surgery for Bypass Grafting
Pilot Study to Establish a Repertoire of Megakaryocyte Markers, Quantifiable by Spectral Flow Cytometry, in Bone Marrow and Circulating in Patients Undergoing Cardiac Surgery for Bypass Grafting
Megakaryopoiesis, the mechanism of blood platelet production, is difficult to assess in clinical practice as it relies solely on microscopic description.
- Trial name
- EPIMéCA (NCT07026851)
- Testing
- Blood and bone marrow sampling
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Acute T-Cell Leukemia-Lymphoma
Campath-1H for Treating Adult T-Cell Leukemia/Lymphoma
This study will examine the safety and effectiveness of Alemtuzumab (Campath-1H) for treating patients with adult T-cell leukemia/lymphoma (ATL).
- Trial name
- NCT00061048
- Testing
- Alemtuzumab
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Cancer Institute (NCI)
Extracorporeal Membrane Oxygenation, Platelet Activation
Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients
The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding…
- Conditions
- Extracorporeal Membrane Oxygenation, Platelet Activation, Platelet Aggregation, Platelet Function Tests
- Trial name
- NCT03355625
- Where
- 2 sites in Denmark
- Volunteers
- 33 people
- Sponsor
- Aarhus University Hospital
Cardiovascular Function
Investigation of the Influence of Gender on Cardiovascular Function
Inflammation is a key initiating and damaging factor in many illnesses including infection, arthritis and cancer but also of particular relevance to this study in diseases of the heart and blood vessels (i.e.
- Trial name
- NCT01582321
- Testing
- Typhoid vaccine, Cantharidin
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Clear Cell Renal Cell Carcinoma
Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma
Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential.
- Trial name
- PEP-C (NCT04053855)
- Testing
- Urinary sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Lupus Nephritis
Urinary T Cell Biomarker for Prediction in Lupus Nephritis
Urinary T-lymphocytes may be predictive for clinical outcome in patients with lupus nephritis. The investigators hypothesize that the amount of CD4+ effector/memory T-cells in urine at time of diagnosis predicts the outcome of…
- Trial name
- NCT04320797
- Testing
- Flow cytometry analysis of urine samples
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 79 people
- Sponsor
- Charite University, Berlin, Germany
Neoplasms
Differential Expression of CD200 in B-chronic Lymphoproliferative Disorders by Multicolour Flow Cytometry
The investigator's goals in this study are to assess : 1. Differential expression of CD200 by using flow cytometric immune-phenotyping in broad range of patients with B-chronic lymphoproliferative disorders (B-CLPD) 2.
- Trial name
- NCT03712488
- Testing
- flowcytometry
- Volunteers
- 50 people
- Sponsor
- Assiut University
Mycosis Fungoides/Sezary Syndrome, Cutaneous T Cell Lymphoma
Evaluation of the KIR3DL2 Marker in Flow Cytometry for Sézary Syndrome Diagnosis, Therapeutic Response and Residual Disease: a Prospective and Multicenter Study
Cutaneous T-cell lymphomas (CTCL) are a group of primary cutaneous lymphomas including Mycosis Fungoides (MF) and Sézary syndrome (SS).
- Trial name
- KISS01 (NCT06651203)
- Testing
- Follow-up
- Volunteers
- 460 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myelodysplastic Syndromes
Development and Prospective Validation of a Standardized Flow Cytometric Assay of Peripheral Blood Neutrophil Myeloperoxidase Expression for Ruling Out Myelodysplastic Syndromes.
Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal bone marrow neoplasms that predominate in the elderly, with a median age at diagnosis of 70 years.
- Trial name
- MPO-MDS-Develp (NCT04399018)
- Testing
- Diagnostic Test: Flow cytometry analysis of neutrophil myeloperoxidase expression
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Grenoble
Leukemia, Myeloid, Acute
Evaluation of Measurable Residual Disease in Patients With Acute Myeloid Leukemia as Surrogate Endpoint for Survival
Objectives To demonstrate that measurable residual disease assessed by multiparameter flow cytometry during intensive treatment is a surrogate for overall survival and thus an early read-out for drug efficacy Study design…
- Trial name
- PERDAM (NCT03549351)
- Testing
- Measurable residual disease measured by flow cytometry
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- University Hospital Heidelberg
Childhood-onset Systemic Lupus Erythematosus
Immune Profiling of Refractory cSLE Exposed to CD3×CD19 BiTE
This prospective observational study aims to characterize the peripheral immune landscape of pediatric patients with childhood-onset systemic lupus erythematosus ( cSLE) who are receiving CD3×CD19 bispecific T-cell engager (BiTE)…
- Trial name
- BiTE-cSLE-IP (NCT07352332)
- Where
- China
- Volunteers
- 6 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Obesity
Cytokine Levels of Patients Who Underwent Obesity Surgery
Obesity is an important public health problem worldwide. There are large regional differences in the prevalence of overweight and obesity. Obesity is a growing problem in both developed and low-income countries.
- Trial name
- NCT04540263
- Testing
- Flow Cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Training and Research Hospital